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Psychosocial influences on HIV-1 disease progression: neural, endocrine, and virologic mechanisms.
Psychosom Med 2008; 70(5):562-8PM

Abstract

This review surveys empirical research pertinent to the hypothesis that activity of the hypothalamus-pituitary-adrenal (HPA) axis and/or the sympathetic nervous system (SNS) might mediate biobehavioral influences on HIV-1 pathogenesis and disease progression. Data are considered based on causal effects of neuroeffector molecules on HIV-1 replication, prospective relationships between neural/endocrine parameters and HIV-relevant biological or clinical markers, and correlational data consistent with in vivo neural/endocrine mediation in human or animal studies. Results show that HPA and SNS effector molecules can enhance HIV-1 replication in cellular models via effects on viral infectivity, viral gene expression, and the innate immune response to infection. Animal models and human clinical studies both provide evidence consistent with SNS regulation of viral replication, but data on HPA mediation are less clear. Regulation of leukocyte biology by neuroeffector molecules provides a plausible biological mechanism by which psychosocial factors might influence HIV-1 pathogenesis, even in the era of effective antiretroviral therapy. As such, neural and endocrine parameters might provide useful biomarkers for gauging the promise of behavioral interventions and suggest novel adjunctive strategies for controlling HIV-1 disease progression.

Authors+Show Affiliations

Department of Medicine, Division of Hematology-Oncology, UCLA School of Medicine, the Norman Cousins Center, Jonsson Comprehensive Cancer Center, UCLA AIDS Institute, California 90095-1678, USA. coles@ucla.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18541906

Citation

Cole, Steve W.. "Psychosocial Influences On HIV-1 Disease Progression: Neural, Endocrine, and Virologic Mechanisms." Psychosomatic Medicine, vol. 70, no. 5, 2008, pp. 562-8.
Cole SW. Psychosocial influences on HIV-1 disease progression: neural, endocrine, and virologic mechanisms. Psychosom Med. 2008;70(5):562-8.
Cole, S. W. (2008). Psychosocial influences on HIV-1 disease progression: neural, endocrine, and virologic mechanisms. Psychosomatic Medicine, 70(5), pp. 562-8. doi:10.1097/PSY.0b013e3181773bbd.
Cole SW. Psychosocial Influences On HIV-1 Disease Progression: Neural, Endocrine, and Virologic Mechanisms. Psychosom Med. 2008;70(5):562-8. PubMed PMID: 18541906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychosocial influences on HIV-1 disease progression: neural, endocrine, and virologic mechanisms. A1 - Cole,Steve W, PY - 2008/6/11/pubmed PY - 2008/9/5/medline PY - 2008/6/11/entrez SP - 562 EP - 8 JF - Psychosomatic medicine JO - Psychosom Med VL - 70 IS - 5 N2 - This review surveys empirical research pertinent to the hypothesis that activity of the hypothalamus-pituitary-adrenal (HPA) axis and/or the sympathetic nervous system (SNS) might mediate biobehavioral influences on HIV-1 pathogenesis and disease progression. Data are considered based on causal effects of neuroeffector molecules on HIV-1 replication, prospective relationships between neural/endocrine parameters and HIV-relevant biological or clinical markers, and correlational data consistent with in vivo neural/endocrine mediation in human or animal studies. Results show that HPA and SNS effector molecules can enhance HIV-1 replication in cellular models via effects on viral infectivity, viral gene expression, and the innate immune response to infection. Animal models and human clinical studies both provide evidence consistent with SNS regulation of viral replication, but data on HPA mediation are less clear. Regulation of leukocyte biology by neuroeffector molecules provides a plausible biological mechanism by which psychosocial factors might influence HIV-1 pathogenesis, even in the era of effective antiretroviral therapy. As such, neural and endocrine parameters might provide useful biomarkers for gauging the promise of behavioral interventions and suggest novel adjunctive strategies for controlling HIV-1 disease progression. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/18541906/Psychosocial_influences_on_HIV_1_disease_progression:_neural_endocrine_and_virologic_mechanisms_ L2 - http://dx.doi.org/10.1097/PSY.0b013e3181773bbd DB - PRIME DP - Unbound Medicine ER -