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Liver diseases unique to pregnancy.
Medicina (Kaunas). 2008; 44(5):337-45.M

Abstract

The aim of this review article is to improve knowledge of the liver disease in pregnancy. The article summarizes the results of own experience and the recent reviews of liver disorders unique to pregnancy. Abnormalities in liver tests occur in 3% of pregnancies with causes ranging from self-limiting to rapidly fatal. In Kaunas University of Medicine Hospital, a retrospective analysis disclosed a rate of 0.52% of liver diseases in 16252 pregnant women over a 5-year period. Several liver diseases occur only during pregnancy and are considered to be associated with the pregnant state. The liver disorders unique to pregnancy have characteristic clinical features and timing of onset. Hyperemesis gravidarum occurs in the first trimester, intrahepatic cholestasis of pregnancy in the second or third trimester, preeclampsia, HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome, and acute fatty liver of pregnancy usually in the third trimester. The disorders of late pregnancy - preeclampsia, HELLP syndrome, and acute fatty liver of pregnancy - may progress to severe liver dysfunction. The correct diagnosis is critical, as any delay can result in morbidity or mortality of both the mother and fetus. Early delivery and advances in supportive management are the only available option for improving the prognosis.

Authors+Show Affiliations

J. Kondrackiene, Department of Gastroenterology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania. jukond@takas.ltNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

18541949

Citation

Kondrackiene, Jūrate, and Limas Kupcinskas. "Liver Diseases Unique to Pregnancy." Medicina (Kaunas, Lithuania), vol. 44, no. 5, 2008, pp. 337-45.
Kondrackiene J, Kupcinskas L. Liver diseases unique to pregnancy. Medicina (Kaunas). 2008;44(5):337-45.
Kondrackiene, J., & Kupcinskas, L. (2008). Liver diseases unique to pregnancy. Medicina (Kaunas, Lithuania), 44(5), 337-45.
Kondrackiene J, Kupcinskas L. Liver Diseases Unique to Pregnancy. Medicina (Kaunas). 2008;44(5):337-45. PubMed PMID: 18541949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver diseases unique to pregnancy. AU - Kondrackiene,Jūrate, AU - Kupcinskas,Limas, PY - 2008/6/11/pubmed PY - 2008/6/21/medline PY - 2008/6/11/entrez SP - 337 EP - 45 JF - Medicina (Kaunas, Lithuania) JO - Medicina (Kaunas) VL - 44 IS - 5 N2 - The aim of this review article is to improve knowledge of the liver disease in pregnancy. The article summarizes the results of own experience and the recent reviews of liver disorders unique to pregnancy. Abnormalities in liver tests occur in 3% of pregnancies with causes ranging from self-limiting to rapidly fatal. In Kaunas University of Medicine Hospital, a retrospective analysis disclosed a rate of 0.52% of liver diseases in 16252 pregnant women over a 5-year period. Several liver diseases occur only during pregnancy and are considered to be associated with the pregnant state. The liver disorders unique to pregnancy have characteristic clinical features and timing of onset. Hyperemesis gravidarum occurs in the first trimester, intrahepatic cholestasis of pregnancy in the second or third trimester, preeclampsia, HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome, and acute fatty liver of pregnancy usually in the third trimester. The disorders of late pregnancy - preeclampsia, HELLP syndrome, and acute fatty liver of pregnancy - may progress to severe liver dysfunction. The correct diagnosis is critical, as any delay can result in morbidity or mortality of both the mother and fetus. Early delivery and advances in supportive management are the only available option for improving the prognosis. SN - 1648-9144 UR - https://www.unboundmedicine.com/medline/citation/18541949/Liver_diseases_unique_to_pregnancy_ DB - PRIME DP - Unbound Medicine ER -