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Nondemented Parkinson disease patients: is cognitive performance associated with depressive difficulties?
Cogn Behav Neurol. 2008 Jun; 21(2):87-91.CB

Abstract

BACKGROUND

Poorer cognitive performance in depressed versus nondepressed nondemented Parkinson disease (PD) patients has been suggested.

OBJECTIVE

Investigate the relationship between level of depression assessed on a depression-measuring scale and cognitive performance in nondemented PD patients.

METHODS

Nondemented idiopathic PD patients (n=110) were evaluated for the level of depression [cognitive-affective items of the Beck's Depression Inventory (BDI)] and performance in a set of tests evaluating cognitive domains typically affected in PD (memory, visuospatial, and executive functions).

RESULTS

Multiple regression analysis of BDI scores demonstrated independent association of poorer cognitive performance, more severe parkinsonism, and poorer education with higher BDI scores. The association between poorer cognition and higher BDI scores was conditional on education, that is, was apparent only in less educated patients (<12 y of formal education).

CONCLUSIONS

Poorer cognitive performance in nondemented idiopathic PD patients is associated with more severe depressive difficulties. Poorer education is also associated with more severe depression. Education modifies the cognition-depression relationship.

Authors+Show Affiliations

Department of Neurology, Clinical University Hospital Zagreb, Medical School, Zagreb, Croatia. natasa.klepac@zg.t-com.hrNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18541984

Citation

Klepac, Natasa, et al. "Nondemented Parkinson Disease Patients: Is Cognitive Performance Associated With Depressive Difficulties?" Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, vol. 21, no. 2, 2008, pp. 87-91.
Klepac N, Trkulja V, Relja M. Nondemented Parkinson disease patients: is cognitive performance associated with depressive difficulties? Cogn Behav Neurol. 2008;21(2):87-91.
Klepac, N., Trkulja, V., & Relja, M. (2008). Nondemented Parkinson disease patients: is cognitive performance associated with depressive difficulties? Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, 21(2), 87-91. https://doi.org/10.1097/WNN.0b013e3181799da6
Klepac N, Trkulja V, Relja M. Nondemented Parkinson Disease Patients: Is Cognitive Performance Associated With Depressive Difficulties. Cogn Behav Neurol. 2008;21(2):87-91. PubMed PMID: 18541984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nondemented Parkinson disease patients: is cognitive performance associated with depressive difficulties? AU - Klepac,Natasa, AU - Trkulja,Vladimir, AU - Relja,Maja, PY - 2008/6/11/pubmed PY - 2008/8/23/medline PY - 2008/6/11/entrez SP - 87 EP - 91 JF - Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology JO - Cogn Behav Neurol VL - 21 IS - 2 N2 - BACKGROUND: Poorer cognitive performance in depressed versus nondepressed nondemented Parkinson disease (PD) patients has been suggested. OBJECTIVE: Investigate the relationship between level of depression assessed on a depression-measuring scale and cognitive performance in nondemented PD patients. METHODS: Nondemented idiopathic PD patients (n=110) were evaluated for the level of depression [cognitive-affective items of the Beck's Depression Inventory (BDI)] and performance in a set of tests evaluating cognitive domains typically affected in PD (memory, visuospatial, and executive functions). RESULTS: Multiple regression analysis of BDI scores demonstrated independent association of poorer cognitive performance, more severe parkinsonism, and poorer education with higher BDI scores. The association between poorer cognition and higher BDI scores was conditional on education, that is, was apparent only in less educated patients (<12 y of formal education). CONCLUSIONS: Poorer cognitive performance in nondemented idiopathic PD patients is associated with more severe depressive difficulties. Poorer education is also associated with more severe depression. Education modifies the cognition-depression relationship. SN - 1543-3641 UR - https://www.unboundmedicine.com/medline/citation/18541984/Nondemented_Parkinson_disease_patients:_is_cognitive_performance_associated_with_depressive_difficulties L2 - https://doi.org/10.1097/WNN.0b013e3181799da6 DB - PRIME DP - Unbound Medicine ER -