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Cosmetic formulations containing Lithospermum erythrorhizon root extract show moisturizing effects on human skin.
Arch Dermatol Res. 2008 Jul; 300(6):317-23.AD

Abstract

Retention of water in the stratum corneum of skin epidermis plays an important role in regulation of skin function. Loss of water may decline skin appearance gradually and lead to irregular skin disorders. The root extract of Lithospermum erythrorhizon (LES) is known for its various pharmacological activities. However, the potential skin care effect of LES is not clear. The aim of this study was to evaluate the moisturizing efficacy and skin barrier repairing activity of LES. For this study, 30 healthy Asian females (age 20-30) with healthy skin had applied the test emulsions twice daily over a period of 28 days. The skin properties were measured by skin bioengineering techniques. Our preliminary results indicated that LES show moisturizing effect on skin hydration in a time- and dose-dependent pattern, and the maximum increase in skin humidity was 11.77 +/- 1.18% for emulsion LES5.00. Particularly, LES-containing emulsions significantly improve skin barrier function by decreasing the value of transepidermal water loss (TEWL) in a time- and dose-dependent pattern, and the maximum decrease in TEWL value was 7.68 +/- 0.79% for emulsion LES5.00. Taken together, our data demonstrate that LES is more effective in increasing skin humidity and decreasing the TEWL values, indicating the potential skin care effects of LES.

Authors+Show Affiliations

Graduate Institute of Chinese Pharmaceutical Sciences, College of Chinese Medicine, China Medical University, Taichung, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18542977

Citation

Chang, Man-Jau, et al. "Cosmetic Formulations Containing Lithospermum Erythrorhizon Root Extract Show Moisturizing Effects On Human Skin." Archives of Dermatological Research, vol. 300, no. 6, 2008, pp. 317-23.
Chang MJ, Huang HC, Chang HC, et al. Cosmetic formulations containing Lithospermum erythrorhizon root extract show moisturizing effects on human skin. Arch Dermatol Res. 2008;300(6):317-23.
Chang, M. J., Huang, H. C., Chang, H. C., & Chang, T. M. (2008). Cosmetic formulations containing Lithospermum erythrorhizon root extract show moisturizing effects on human skin. Archives of Dermatological Research, 300(6), 317-23. https://doi.org/10.1007/s00403-008-0867-9
Chang MJ, et al. Cosmetic Formulations Containing Lithospermum Erythrorhizon Root Extract Show Moisturizing Effects On Human Skin. Arch Dermatol Res. 2008;300(6):317-23. PubMed PMID: 18542977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cosmetic formulations containing Lithospermum erythrorhizon root extract show moisturizing effects on human skin. AU - Chang,Man-Jau, AU - Huang,Huey-Chun, AU - Chang,Hsien-Cheh, AU - Chang,Tsong-Min, Y1 - 2008/06/10/ PY - 2007/07/02/received PY - 2008/05/23/accepted PY - 2008/04/09/revised PY - 2008/6/11/pubmed PY - 2009/6/6/medline PY - 2008/6/11/entrez SP - 317 EP - 23 JF - Archives of dermatological research JO - Arch Dermatol Res VL - 300 IS - 6 N2 - Retention of water in the stratum corneum of skin epidermis plays an important role in regulation of skin function. Loss of water may decline skin appearance gradually and lead to irregular skin disorders. The root extract of Lithospermum erythrorhizon (LES) is known for its various pharmacological activities. However, the potential skin care effect of LES is not clear. The aim of this study was to evaluate the moisturizing efficacy and skin barrier repairing activity of LES. For this study, 30 healthy Asian females (age 20-30) with healthy skin had applied the test emulsions twice daily over a period of 28 days. The skin properties were measured by skin bioengineering techniques. Our preliminary results indicated that LES show moisturizing effect on skin hydration in a time- and dose-dependent pattern, and the maximum increase in skin humidity was 11.77 +/- 1.18% for emulsion LES5.00. Particularly, LES-containing emulsions significantly improve skin barrier function by decreasing the value of transepidermal water loss (TEWL) in a time- and dose-dependent pattern, and the maximum decrease in TEWL value was 7.68 +/- 0.79% for emulsion LES5.00. Taken together, our data demonstrate that LES is more effective in increasing skin humidity and decreasing the TEWL values, indicating the potential skin care effects of LES. SN - 1432-069X UR - https://www.unboundmedicine.com/medline/citation/18542977/Cosmetic_formulations_containing_Lithospermum_erythrorhizon_root_extract_show_moisturizing_effects_on_human_skin_ L2 - https://link.springer.com/article/10.1007/s00403-008-0867-9 DB - PRIME DP - Unbound Medicine ER -