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Value of risk stratification to increase the predictive validity of HbA1c in screening for undiagnosed diabetes in the US population.
J Gen Intern Med. 2008 Sep; 23(9):1346-53.JG

Abstract

BACKGROUND

Opportunistic screening using hemoglobin A1c (HbA1c) may improve detection of undiagnosed diabetes but remains controversial.

OBJECTIVE

To evaluate the predictive validity of HbA1c as a screening test for undiagnosed diabetes in a risk-stratified sample of the US population.

DESIGN

Weighted cross-sectional analysis of diabetes risk factors, HbA1c, and fasting plasma glucose (FPG) in National Health and Nutrition Examination Survey (NHANES), 1999-2004.

SUBJECTS

Six thousand seven hundred and twenty-three NHANES participants from morning examination session, aged > or = 18 years and without prior physician-diagnosed diabetes.

MEASUREMENTS

HbA1c and undiagnosed diabetes defined by FPG > or = 7.0 mmol/l (126 mg/dl).

RESULTS

The estimated prevalence of undiagnosed diabetes in the US population was 2.8% (5.5 million people). HbA1c had strong correlation with undiagnosed diabetes, with an area under the receiver-operating characteristic curve of 0.93. Independent predictors of undiagnosed diabetes were older age, male sex, black race, hypertension, elevated waist circumference, elevated triglycerides, and low high-density lipoprotein cholesterol. We derived a risk score for undiagnosed diabetes and stratified participants into low (0.44% prevalence), moderate (4.1% prevalence), and high (11.1% prevalence) risk subgroups. In moderate and high risk groups, a threshold HbA1c value > or = 6.1% identified patients requiring confirmatory FPG; HbA1c < or = 5.4% identified patients for whom diabetes could be reliably excluded. Intermediate HbA1c (5.5-6.0%) may exclude diabetes in moderate, but not high risk groups).

CONCLUSIONS

Risk stratification improves the predictive validity of HbA1c in screening for undiagnosed diabetes in the US population. Although opportunistic screening with HbA1c would improve detection of undiagnosed diabetes, cost-effectiveness studies are needed before implementation of specific screening strategies using HbA1c.

Authors+Show Affiliations

Department of Emergency Medicine, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA. adit.ginde@uchsc.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

18543044

Citation

Ginde, Adit A., et al. "Value of Risk Stratification to Increase the Predictive Validity of HbA1c in Screening for Undiagnosed Diabetes in the US Population." Journal of General Internal Medicine, vol. 23, no. 9, 2008, pp. 1346-53.
Ginde AA, Cagliero E, Nathan DM, et al. Value of risk stratification to increase the predictive validity of HbA1c in screening for undiagnosed diabetes in the US population. J Gen Intern Med. 2008;23(9):1346-53.
Ginde, A. A., Cagliero, E., Nathan, D. M., & Camargo, C. A. (2008). Value of risk stratification to increase the predictive validity of HbA1c in screening for undiagnosed diabetes in the US population. Journal of General Internal Medicine, 23(9), 1346-53. https://doi.org/10.1007/s11606-008-0661-6
Ginde AA, et al. Value of Risk Stratification to Increase the Predictive Validity of HbA1c in Screening for Undiagnosed Diabetes in the US Population. J Gen Intern Med. 2008;23(9):1346-53. PubMed PMID: 18543044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Value of risk stratification to increase the predictive validity of HbA1c in screening for undiagnosed diabetes in the US population. AU - Ginde,Adit A, AU - Cagliero,Enrico, AU - Nathan,David M, AU - Camargo,Carlos A,Jr Y1 - 2008/06/10/ PY - 2007/08/29/received PY - 2008/04/25/accepted PY - 2008/01/29/revised PY - 2008/6/11/pubmed PY - 2008/12/17/medline PY - 2008/6/11/entrez SP - 1346 EP - 53 JF - Journal of general internal medicine JO - J Gen Intern Med VL - 23 IS - 9 N2 - BACKGROUND: Opportunistic screening using hemoglobin A1c (HbA1c) may improve detection of undiagnosed diabetes but remains controversial. OBJECTIVE: To evaluate the predictive validity of HbA1c as a screening test for undiagnosed diabetes in a risk-stratified sample of the US population. DESIGN: Weighted cross-sectional analysis of diabetes risk factors, HbA1c, and fasting plasma glucose (FPG) in National Health and Nutrition Examination Survey (NHANES), 1999-2004. SUBJECTS: Six thousand seven hundred and twenty-three NHANES participants from morning examination session, aged > or = 18 years and without prior physician-diagnosed diabetes. MEASUREMENTS: HbA1c and undiagnosed diabetes defined by FPG > or = 7.0 mmol/l (126 mg/dl). RESULTS: The estimated prevalence of undiagnosed diabetes in the US population was 2.8% (5.5 million people). HbA1c had strong correlation with undiagnosed diabetes, with an area under the receiver-operating characteristic curve of 0.93. Independent predictors of undiagnosed diabetes were older age, male sex, black race, hypertension, elevated waist circumference, elevated triglycerides, and low high-density lipoprotein cholesterol. We derived a risk score for undiagnosed diabetes and stratified participants into low (0.44% prevalence), moderate (4.1% prevalence), and high (11.1% prevalence) risk subgroups. In moderate and high risk groups, a threshold HbA1c value > or = 6.1% identified patients requiring confirmatory FPG; HbA1c < or = 5.4% identified patients for whom diabetes could be reliably excluded. Intermediate HbA1c (5.5-6.0%) may exclude diabetes in moderate, but not high risk groups). CONCLUSIONS: Risk stratification improves the predictive validity of HbA1c in screening for undiagnosed diabetes in the US population. Although opportunistic screening with HbA1c would improve detection of undiagnosed diabetes, cost-effectiveness studies are needed before implementation of specific screening strategies using HbA1c. SN - 1525-1497 UR - https://www.unboundmedicine.com/medline/citation/18543044/Value_of_risk_stratification_to_increase_the_predictive_validity_of_HbA1c_in_screening_for_undiagnosed_diabetes_in_the_US_population_ L2 - https://dx.doi.org/10.1007/s11606-008-0661-6 DB - PRIME DP - Unbound Medicine ER -