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Model for end-stage liver disease, model for end-stage liver disease-sodium and Child-Turcotte-Pugh scores over time for the prediction of complications of liver cirrhosis.
Liver Int. 2009 Feb; 29(2):221-6.LI

Abstract

BACKGROUND/AIMS

There has been no report concerning the predictive capability of each scoring system in determining the development of complications of liver cirrhosis such as variceal bleeding and/or hepatic encephalopathy.

METHODS

We retrospectively studied 128 patients with liver cirrhosis [92 males; mean (standard deviation) 54.2 (11.2) years] admitted to our institution from March 2004 to April 2006. Seventy-three patients (57.0%, group 1) were admitted because of complications of cirrhosis and 55 patients (43.0%, group 2) were admitted for causes unrelated to complications of cirrhosis. We calculated values for model for end-stage liver disease (MELD), MELD-sodium (MELD-Na) and Child-Turcotte-Pugh (CTP) scores on admission and at 3 and 6 months before admission. Each delta score was defined as the difference in the scores of 3 and 6 months before admission.

RESULTS

The relative risk for complications in the patients with DeltaMELD/3 months >/=1.35, DeltaMELD-Na/3 months >/=1.35 and DeltaCTP/3 months >/=1 was 2.05 [95% confidence intervals (CI) 1.47-2.85, P<0.01], 2.04 (95% CI 1.45-2.88, P<0.01) and 1.98 (95% CI 1.39-2.81, P<0.01) respectively. The area under the receiver-operating characteristic curves of DeltaMELD/3 months, DeltaMELD-Na/3 months and DeltaCTP/3 months for the occurrence of cirrhotic complications were 0.691, 0.694 and 0.722 respectively. A higher DeltaMELD/3 months (>/=1.35), DeltaMELD-Na/3 months (>/=1.35) and DeltaCTP/3 months (>/=1) was associated with decreased survival.

CONCLUSIONS

Delta model for end-stage liver disease/3 months, DeltaMELD-Na/3 months and DeltaCTP/3 months were clinically useful parameters for predicting the occurrence of cirrhotic complications.

Authors+Show Affiliations

Department of Emergency Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18544124

Citation

Choi, Pil Cho, et al. "Model for End-stage Liver Disease, Model for End-stage Liver Disease-sodium and Child-Turcotte-Pugh Scores Over Time for the Prediction of Complications of Liver Cirrhosis." Liver International : Official Journal of the International Association for the Study of the Liver, vol. 29, no. 2, 2009, pp. 221-6.
Choi PC, Kim HJ, Choi WH, et al. Model for end-stage liver disease, model for end-stage liver disease-sodium and Child-Turcotte-Pugh scores over time for the prediction of complications of liver cirrhosis. Liver Int. 2009;29(2):221-6.
Choi, P. C., Kim, H. J., Choi, W. H., Park, D. I., Park, J. H., Cho, Y. K., Sohn, C. I., Jeon, W. K., & Kim, B. I. (2009). Model for end-stage liver disease, model for end-stage liver disease-sodium and Child-Turcotte-Pugh scores over time for the prediction of complications of liver cirrhosis. Liver International : Official Journal of the International Association for the Study of the Liver, 29(2), 221-6. https://doi.org/10.1111/j.1478-3231.2008.01803.x
Choi PC, et al. Model for End-stage Liver Disease, Model for End-stage Liver Disease-sodium and Child-Turcotte-Pugh Scores Over Time for the Prediction of Complications of Liver Cirrhosis. Liver Int. 2009;29(2):221-6. PubMed PMID: 18544124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Model for end-stage liver disease, model for end-stage liver disease-sodium and Child-Turcotte-Pugh scores over time for the prediction of complications of liver cirrhosis. AU - Choi,Pil Cho, AU - Kim,Hong Joo, AU - Choi,Woo Hyuk, AU - Park,Dong Il, AU - Park,Jung Ho, AU - Cho,Yong Kyun, AU - Sohn,Chong Il, AU - Jeon,Woo Kyu, AU - Kim,Byung Ik, Y1 - 2008/06/09/ PY - 2008/6/12/pubmed PY - 2009/6/2/medline PY - 2008/6/12/entrez SP - 221 EP - 6 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int VL - 29 IS - 2 N2 - BACKGROUND/AIMS: There has been no report concerning the predictive capability of each scoring system in determining the development of complications of liver cirrhosis such as variceal bleeding and/or hepatic encephalopathy. METHODS: We retrospectively studied 128 patients with liver cirrhosis [92 males; mean (standard deviation) 54.2 (11.2) years] admitted to our institution from March 2004 to April 2006. Seventy-three patients (57.0%, group 1) were admitted because of complications of cirrhosis and 55 patients (43.0%, group 2) were admitted for causes unrelated to complications of cirrhosis. We calculated values for model for end-stage liver disease (MELD), MELD-sodium (MELD-Na) and Child-Turcotte-Pugh (CTP) scores on admission and at 3 and 6 months before admission. Each delta score was defined as the difference in the scores of 3 and 6 months before admission. RESULTS: The relative risk for complications in the patients with DeltaMELD/3 months >/=1.35, DeltaMELD-Na/3 months >/=1.35 and DeltaCTP/3 months >/=1 was 2.05 [95% confidence intervals (CI) 1.47-2.85, P<0.01], 2.04 (95% CI 1.45-2.88, P<0.01) and 1.98 (95% CI 1.39-2.81, P<0.01) respectively. The area under the receiver-operating characteristic curves of DeltaMELD/3 months, DeltaMELD-Na/3 months and DeltaCTP/3 months for the occurrence of cirrhotic complications were 0.691, 0.694 and 0.722 respectively. A higher DeltaMELD/3 months (>/=1.35), DeltaMELD-Na/3 months (>/=1.35) and DeltaCTP/3 months (>/=1) was associated with decreased survival. CONCLUSIONS: Delta model for end-stage liver disease/3 months, DeltaMELD-Na/3 months and DeltaCTP/3 months were clinically useful parameters for predicting the occurrence of cirrhotic complications. SN - 1478-3231 UR - https://www.unboundmedicine.com/medline/citation/18544124/Model_for_end_stage_liver_disease_model_for_end_stage_liver_disease_sodium_and_Child_Turcotte_Pugh_scores_over_time_for_the_prediction_of_complications_of_liver_cirrhosis_ L2 - https://doi.org/10.1111/j.1478-3231.2008.01803.x DB - PRIME DP - Unbound Medicine ER -