Tags

Type your tag names separated by a space and hit enter

Oral vitamin C supplementation in hemodialysis patients and its effect on the plasma level of oxidized ascorbic acid and Cu/Zn superoxide dismutase, an oxidative stress marker.
Nephron Clin Pract. 2008; 109(2):c49-54.NC

Abstract

BACKGROUND/AIM

Oxidative stress is known to be enhanced in hemodialysis patients, and one of its useful markers is plasma copper/zinc superoxide dismutase (Cu/Zn-SOD). The increase in plasma Cu/Zn-SOD can be inhibited by orally administered lipid-soluble vitamin E. We examined the antioxidative effects of water-soluble vitamin C administered orally on Cu/Zn-SOD levels in hemodialysis patients.

METHODS

Vitamin C was orally administered to 16 maintenance hemodialysis patients before each dialysis session. Doses were increased from 200 to 1,000 mg over 3 months. The levels of plasma vitamin C and Cu/Zn-SOD and its mRNA expression in leukocytes were determined 1, 2, and 3 months after the start of vitamin C administration. Furthermore, the levels of oxidized and reduced forms of plasma vitamin C were determined before the start of vitamin C administration and before and after dialysis at 1,000-mg vitamin C doses.

RESULTS

Following oral administration, the plasma levels of vitamin C and its oxidized form were increased. However, significant changes in plasma Cu/Zn-SOD or its mRNA expression in leukocytes were not observed.

CONCLUSION

In maintenance hemodialysis patients, vitamin C administration resulted in a significant increase in the postdialysis level of the oxidized form of vitamin C, which suggested an increase in antioxidant effect. However, water-soluble vitamin C did not significantly suppress Cu/Zn-SOD expression enhancement.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan. washio@med.showa-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18544955

Citation

Washio, Kazunori, et al. "Oral Vitamin C Supplementation in Hemodialysis Patients and Its Effect On the Plasma Level of Oxidized Ascorbic Acid and Cu/Zn Superoxide Dismutase, an Oxidative Stress Marker." Nephron. Clinical Practice, vol. 109, no. 2, 2008, pp. c49-54.
Washio K, Inagaki M, Tsuji M, et al. Oral vitamin C supplementation in hemodialysis patients and its effect on the plasma level of oxidized ascorbic acid and Cu/Zn superoxide dismutase, an oxidative stress marker. Nephron Clin Pract. 2008;109(2):c49-54.
Washio, K., Inagaki, M., Tsuji, M., Morio, Y., Akiyama, S., Gotoh, H., Gotoh, T., Gotoh, Y., & Oguchi, K. (2008). Oral vitamin C supplementation in hemodialysis patients and its effect on the plasma level of oxidized ascorbic acid and Cu/Zn superoxide dismutase, an oxidative stress marker. Nephron. Clinical Practice, 109(2), c49-54. https://doi.org/10.1159/000137628
Washio K, et al. Oral Vitamin C Supplementation in Hemodialysis Patients and Its Effect On the Plasma Level of Oxidized Ascorbic Acid and Cu/Zn Superoxide Dismutase, an Oxidative Stress Marker. Nephron Clin Pract. 2008;109(2):c49-54. PubMed PMID: 18544955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral vitamin C supplementation in hemodialysis patients and its effect on the plasma level of oxidized ascorbic acid and Cu/Zn superoxide dismutase, an oxidative stress marker. AU - Washio,Kazunori, AU - Inagaki,Masahiro, AU - Tsuji,Mayumi, AU - Morio,Yuri, AU - Akiyama,Shinichiro, AU - Gotoh,Hiromichi, AU - Gotoh,Tomomi, AU - Gotoh,Yoshikazu, AU - Oguchi,Katsuji, Y1 - 2008/06/10/ PY - 2007/03/02/received PY - 2008/01/30/accepted PY - 2008/6/12/pubmed PY - 2008/10/7/medline PY - 2008/6/12/entrez SP - c49 EP - 54 JF - Nephron. Clinical practice JO - Nephron Clin Pract VL - 109 IS - 2 N2 - BACKGROUND/AIM: Oxidative stress is known to be enhanced in hemodialysis patients, and one of its useful markers is plasma copper/zinc superoxide dismutase (Cu/Zn-SOD). The increase in plasma Cu/Zn-SOD can be inhibited by orally administered lipid-soluble vitamin E. We examined the antioxidative effects of water-soluble vitamin C administered orally on Cu/Zn-SOD levels in hemodialysis patients. METHODS: Vitamin C was orally administered to 16 maintenance hemodialysis patients before each dialysis session. Doses were increased from 200 to 1,000 mg over 3 months. The levels of plasma vitamin C and Cu/Zn-SOD and its mRNA expression in leukocytes were determined 1, 2, and 3 months after the start of vitamin C administration. Furthermore, the levels of oxidized and reduced forms of plasma vitamin C were determined before the start of vitamin C administration and before and after dialysis at 1,000-mg vitamin C doses. RESULTS: Following oral administration, the plasma levels of vitamin C and its oxidized form were increased. However, significant changes in plasma Cu/Zn-SOD or its mRNA expression in leukocytes were not observed. CONCLUSION: In maintenance hemodialysis patients, vitamin C administration resulted in a significant increase in the postdialysis level of the oxidized form of vitamin C, which suggested an increase in antioxidant effect. However, water-soluble vitamin C did not significantly suppress Cu/Zn-SOD expression enhancement. SN - 1660-2110 UR - https://www.unboundmedicine.com/medline/citation/18544955/Oral_vitamin_C_supplementation_in_hemodialysis_patients_and_its_effect_on_the_plasma_level_of_oxidized_ascorbic_acid_and_Cu/Zn_superoxide_dismutase_an_oxidative_stress_marker_ L2 - https://www.karger.com?DOI=10.1159/000137628 DB - PRIME DP - Unbound Medicine ER -