Tags

Type your tag names separated by a space and hit enter

In school-aged children a combination of galacto-oligosaccharides and Lactobacillus GG increases bifidobacteria more than Lactobacillus GG on its own.
Ann Nutr Metab. 2008; 52(3):204-8.AN

Abstract

The aim of this study was to compare a combination of Lactobacillus GG (LGG) and galacto-oligosaccharides (GOS) with LGG on its own, and their effects on the intestinal microbiota in school-aged children. The randomized, double-blinded, crossover study comprised 30 healthy children. There were two 3-week study periods with a 4-week wash-out period in between. The children ingested daily 65 ml of milk-based fruit juice containing either LGG alone (6.5 x 10(9) CFU) or LGG plus 2 g of GOS. Symptom diaries were filled during the study periods. Fecal samples were collected at the beginning and end of both study periods. At the end of both study periods, the amount of bifidobacteria was significantly greater after the ingestion of LGG + GOS compared with LGG alone (geometric mean 9.33 x 10(9) vs. 4.28 x 10(9) CFU/g, p < 0.001). No significant differences were seen in the amount of lactobacilli or LGG, nor did gastrointestinal symptoms, defecation frequency, consistency of stools or ease of defecation differ between the two study periods. Ingestion of LGG combined with 2 g of GOS increased the bifidobacteria more than LGG on its own and thus GOS clearly has a prebiotic effect in children. The children tolerated well a daily intake of 2 g of GOS.

Authors+Show Affiliations

Nutraceuticals Group, Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18544974

Citation

Piirainen, Laura, et al. "In School-aged Children a Combination of Galacto-oligosaccharides and Lactobacillus GG Increases Bifidobacteria More Than Lactobacillus GG On Its Own." Annals of Nutrition & Metabolism, vol. 52, no. 3, 2008, pp. 204-8.
Piirainen L, Kekkonen RA, Kajander K, et al. In school-aged children a combination of galacto-oligosaccharides and Lactobacillus GG increases bifidobacteria more than Lactobacillus GG on its own. Ann Nutr Metab. 2008;52(3):204-8.
Piirainen, L., Kekkonen, R. A., Kajander, K., Ahlroos, T., Tynkkynen, S., Nevala, R., & Korpela, R. (2008). In school-aged children a combination of galacto-oligosaccharides and Lactobacillus GG increases bifidobacteria more than Lactobacillus GG on its own. Annals of Nutrition & Metabolism, 52(3), 204-8. https://doi.org/10.1159/000138124
Piirainen L, et al. In School-aged Children a Combination of Galacto-oligosaccharides and Lactobacillus GG Increases Bifidobacteria More Than Lactobacillus GG On Its Own. Ann Nutr Metab. 2008;52(3):204-8. PubMed PMID: 18544974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In school-aged children a combination of galacto-oligosaccharides and Lactobacillus GG increases bifidobacteria more than Lactobacillus GG on its own. AU - Piirainen,Laura, AU - Kekkonen,Riina A, AU - Kajander,Kajsa, AU - Ahlroos,Terhi, AU - Tynkkynen,Soile, AU - Nevala,Riikka, AU - Korpela,Riitta, Y1 - 2008/06/11/ PY - 2007/06/25/received PY - 2007/12/21/accepted PY - 2008/6/12/pubmed PY - 2008/9/4/medline PY - 2008/6/12/entrez SP - 204 EP - 8 JF - Annals of nutrition & metabolism JO - Ann Nutr Metab VL - 52 IS - 3 N2 - The aim of this study was to compare a combination of Lactobacillus GG (LGG) and galacto-oligosaccharides (GOS) with LGG on its own, and their effects on the intestinal microbiota in school-aged children. The randomized, double-blinded, crossover study comprised 30 healthy children. There were two 3-week study periods with a 4-week wash-out period in between. The children ingested daily 65 ml of milk-based fruit juice containing either LGG alone (6.5 x 10(9) CFU) or LGG plus 2 g of GOS. Symptom diaries were filled during the study periods. Fecal samples were collected at the beginning and end of both study periods. At the end of both study periods, the amount of bifidobacteria was significantly greater after the ingestion of LGG + GOS compared with LGG alone (geometric mean 9.33 x 10(9) vs. 4.28 x 10(9) CFU/g, p < 0.001). No significant differences were seen in the amount of lactobacilli or LGG, nor did gastrointestinal symptoms, defecation frequency, consistency of stools or ease of defecation differ between the two study periods. Ingestion of LGG combined with 2 g of GOS increased the bifidobacteria more than LGG on its own and thus GOS clearly has a prebiotic effect in children. The children tolerated well a daily intake of 2 g of GOS. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/18544974/In_school_aged_children_a_combination_of_galacto_oligosaccharides_and_Lactobacillus_GG_increases_bifidobacteria_more_than_Lactobacillus_GG_on_its_own_ L2 - https://www.karger.com?DOI=10.1159/000138124 DB - PRIME DP - Unbound Medicine ER -