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Cognitive dysfunction in Nigerians with Parkinson's disease.
Mov Disord. 2008 Jul 30; 23(10):1378-83.MD

Abstract

Despite the original description of Parkinson's disease (PD) as a disorder in which "the senses and intellect remain uninjured," there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI'D') and selected items from the Ibadan Neuropsychological Battery (I-NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI'D' score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P < 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08-1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. Older age at disease onset is an important determinant of cognitive dysfunction in PD.

Authors+Show Affiliations

Division of Neurology, Department of Medicine, Federal Medical Centre, Abeokuta, Nigeria. rufusakinyemi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

18546341

Citation

Akinyemi, Rufus O., et al. "Cognitive Dysfunction in Nigerians With Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23, no. 10, 2008, pp. 1378-83.
Akinyemi RO, Okubadejo NN, Akinyemi JO, et al. Cognitive dysfunction in Nigerians with Parkinson's disease. Mov Disord. 2008;23(10):1378-83.
Akinyemi, R. O., Okubadejo, N. N., Akinyemi, J. O., Owolabi, M. O., Owolabi, L. F., & Ogunniyi, A. (2008). Cognitive dysfunction in Nigerians with Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 23(10), 1378-83. https://doi.org/10.1002/mds.22087
Akinyemi RO, et al. Cognitive Dysfunction in Nigerians With Parkinson's Disease. Mov Disord. 2008 Jul 30;23(10):1378-83. PubMed PMID: 18546341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive dysfunction in Nigerians with Parkinson's disease. AU - Akinyemi,Rufus O, AU - Okubadejo,Njideka N, AU - Akinyemi,Joshua O, AU - Owolabi,Mayowa O, AU - Owolabi,Lukman F, AU - Ogunniyi,Adesola, PY - 2008/6/12/pubmed PY - 2008/11/19/medline PY - 2008/6/12/entrez SP - 1378 EP - 83 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 23 IS - 10 N2 - Despite the original description of Parkinson's disease (PD) as a disorder in which "the senses and intellect remain uninjured," there is now sufficient evidence that cognitive dysfunction does occur. This research determined the frequency, pattern, and predictors of cognitive dysfunction among 51 Nigerian patients with PD compared with 50 demographically matched controls using the modified Community Screening Instrument for Dementia (CSI'D') and selected items from the Ibadan Neuropsychological Battery (I-NB). In all, 21.6% patients with PD (4% of controls) exhibited cognitive impairment (P = 0.008) defined, for the purposes of this study, as total modified CSI'D' score below 2 SD of the mean score of the control group. Cognitive dysfunction in patients with PD encompassed memory, language, and executive dysfunction. Correlates of cognitive dysfunction included older age at PD onset (P = 0.001), older current age (P < 0.001), and higher UPDRS motor score (P = 0.005). After logistic regression, older age at onset of PD was the only independent predictor of cognitive dysfunction. (O.R = 1.29; 95% CI = 1.08-1.57, P = 0.006). Cognitive dysfunction occurs more frequently in Nigerians with PD compared to controls. Older age at disease onset is an important determinant of cognitive dysfunction in PD. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/18546341/Cognitive_dysfunction_in_Nigerians_with_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.22087 DB - PRIME DP - Unbound Medicine ER -