Tags

Type your tag names separated by a space and hit enter

[Clinical value of hepatic fibrosis parameters and serum ferritin in obese children with nonalcoholic fatty liver disease].

Abstract

OBJECTIVE

To determine the clinical value of hepatic fibrosis parameters and serum ferritin (SF) in obese children with nonalcoholic fatty liver disease.

METHODS

One hundred and one obese children aged 6-15 years and 30 healthy children aged 9-14 years were enrolled in the study. Body mass index (BMI), waist circumference (WC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatic fibrosis parameters including hyaluronic acid (HA), laminin (LN), serum type III procollagen (PCIII) and type IV collagen (CIV), serum ferritin and hepatic B-ultrasonography were assessed. All subjects were divided into 4 subgroups: simple obese children (SOC), simple nonalcoholic fatty liver (SNAFL), nonalcoholic steatohepatitis (NASH) and control group. ALT, AST, hepatic fibrosis parameters and serum ferritin were compared in these four groups.

RESULT

Compared with control group, the serum levels of HA and PCIII increased significantly in SOC group (P <0.05); Serum levels of HA, PCIII, SF, ALT and AST also elevated markedly in SNAFL group and NASH group compared with those in control group. PCIII, SF, ALT, AST increased stepwise as the disease developed from SOC to SNAFL and NASH (P <0.05). SF was correlated with PCIII, ALT and AST (r=0.33,0.63,0.69,P <0.05) and PCIII was well related to ALT and AST (r=0.55,0.56,P <0.05). There were only 6 cases with SF >301 microg/L among all obese children, they were all NASH. The average levels of HA, CIV, PCIII, ALT, AST of these 6 cases were significantly higher than those of other NASH children.

CONCLUSION

Among all hepatic fibrosis parameters, serum PCIII level is an early and sensitive indicator of NAFLD and is correlated with the disease progress. SF may be also involved in early injury of fatty liver and the process of NAFLD.

Authors+Show Affiliations

Department of Endocrinology, The Affiliated Children's Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18546525

Citation

Shi, Hong-Bo, et al. "[Clinical Value of Hepatic Fibrosis Parameters and Serum Ferritin in Obese Children With Nonalcoholic Fatty Liver Disease]." Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, vol. 37, no. 3, 2008, pp. 245-9.
Shi HB, Fu JF, Wang CL. [Clinical value of hepatic fibrosis parameters and serum ferritin in obese children with nonalcoholic fatty liver disease]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008;37(3):245-9.
Shi, H. B., Fu, J. F., & Wang, C. L. (2008). [Clinical value of hepatic fibrosis parameters and serum ferritin in obese children with nonalcoholic fatty liver disease]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences, 37(3), pp. 245-9.
Shi HB, Fu JF, Wang CL. [Clinical Value of Hepatic Fibrosis Parameters and Serum Ferritin in Obese Children With Nonalcoholic Fatty Liver Disease]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008;37(3):245-9. PubMed PMID: 18546525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical value of hepatic fibrosis parameters and serum ferritin in obese children with nonalcoholic fatty liver disease]. AU - Shi,Hong-Bo, AU - Fu,Jun-Fen, AU - Wang,Chun-Lin, PY - 2008/6/12/pubmed PY - 2010/3/31/medline PY - 2008/6/12/entrez SP - 245 EP - 9 JF - Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences JO - Zhejiang Da Xue Xue Bao Yi Xue Ban VL - 37 IS - 3 N2 - OBJECTIVE: To determine the clinical value of hepatic fibrosis parameters and serum ferritin (SF) in obese children with nonalcoholic fatty liver disease. METHODS: One hundred and one obese children aged 6-15 years and 30 healthy children aged 9-14 years were enrolled in the study. Body mass index (BMI), waist circumference (WC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatic fibrosis parameters including hyaluronic acid (HA), laminin (LN), serum type III procollagen (PCIII) and type IV collagen (CIV), serum ferritin and hepatic B-ultrasonography were assessed. All subjects were divided into 4 subgroups: simple obese children (SOC), simple nonalcoholic fatty liver (SNAFL), nonalcoholic steatohepatitis (NASH) and control group. ALT, AST, hepatic fibrosis parameters and serum ferritin were compared in these four groups. RESULT: Compared with control group, the serum levels of HA and PCIII increased significantly in SOC group (P <0.05); Serum levels of HA, PCIII, SF, ALT and AST also elevated markedly in SNAFL group and NASH group compared with those in control group. PCIII, SF, ALT, AST increased stepwise as the disease developed from SOC to SNAFL and NASH (P <0.05). SF was correlated with PCIII, ALT and AST (r=0.33,0.63,0.69,P <0.05) and PCIII was well related to ALT and AST (r=0.55,0.56,P <0.05). There were only 6 cases with SF >301 microg/L among all obese children, they were all NASH. The average levels of HA, CIV, PCIII, ALT, AST of these 6 cases were significantly higher than those of other NASH children. CONCLUSION: Among all hepatic fibrosis parameters, serum PCIII level is an early and sensitive indicator of NAFLD and is correlated with the disease progress. SF may be also involved in early injury of fatty liver and the process of NAFLD. SN - 1008-9292 UR - https://www.unboundmedicine.com/medline/citation/18546525/[Clinical_value_of_hepatic_fibrosis_parameters_and_serum_ferritin_in_obese_children_with_nonalcoholic_fatty_liver_disease]_ L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -