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Dietary fatty acids, age-related cognitive decline, and mild cognitive impairment.

Abstract

Currently available epidemiological evidence suggested that an increase of saturated fatty acids (SFA) could have negative effects on cognitive functions, while increased polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) may be protective against cognitive decline. In a Southern Italian elderly population from the Italian Longitudinal Study on Aging (ILSA), a clear reduction of risk of age-related cognitive decline (ARCD) has been found with elevated intake of PUFA and MUFA. Furthermore, in the ILSA, while dietary fatty acids intakes were not associated with incident mild cognitive impairment (MCI), high PUFA intake appeared to have borderline non-significant trend for a protective effect against the development of MCI. These epidemiological findings on predementia syndromes, i.e. MCI or ARCD, together with a recent randomised controlled trial on a possible effect on cognitive and depressive symptoms of omega-3 PUFA supplementation in patients with very mild AD, suggested a possible role of fatty acids intake in maintaining adequate cognitive functioning and possibly in preventing or delaying the onset of dementia.

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Authors+Show Affiliations

,

Department of Geriatrics, Center for Aging Brain, Memory Unit University of Bari, Bari, Italy. v.solfrizzi@geriatria.uniba.it

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Source

MeSH

Aged
Aged, 80 and over
Aging
Cognition Disorders
Dietary Fats
Fatty Acids
Fatty Acids, Monounsaturated
Fatty Acids, Unsaturated
Humans
Italy
Longitudinal Studies
Risk Factors
Severity of Illness Index

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18548175

Citation

Solfrizzi, V, et al. "Dietary Fatty Acids, Age-related Cognitive Decline, and Mild Cognitive Impairment." The Journal of Nutrition, Health & Aging, vol. 12, no. 6, 2008, pp. 382-6.
Solfrizzi V, Capurso C, D'Introno A, et al. Dietary fatty acids, age-related cognitive decline, and mild cognitive impairment. J Nutr Health Aging. 2008;12(6):382-6.
Solfrizzi, V., Capurso, C., D'Introno, A., Colacicco, A. M., Frisardi, V., Santamato, A., ... Panza, F. (2008). Dietary fatty acids, age-related cognitive decline, and mild cognitive impairment. The Journal of Nutrition, Health & Aging, 12(6), pp. 382-6.
Solfrizzi V, et al. Dietary Fatty Acids, Age-related Cognitive Decline, and Mild Cognitive Impairment. J Nutr Health Aging. 2008;12(6):382-6. PubMed PMID: 18548175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fatty acids, age-related cognitive decline, and mild cognitive impairment. AU - Solfrizzi,V, AU - Capurso,C, AU - D'Introno,A, AU - Colacicco,A M, AU - Frisardi,V, AU - Santamato,A, AU - Ranieri,M, AU - Fiore,P, AU - Vendemiale,G, AU - Seripa,D, AU - Pilotto,A, AU - Capurso,A, AU - Panza,F, PY - 2008/6/13/pubmed PY - 2009/1/7/medline PY - 2008/6/13/entrez SP - 382 EP - 6 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 12 IS - 6 N2 - Currently available epidemiological evidence suggested that an increase of saturated fatty acids (SFA) could have negative effects on cognitive functions, while increased polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA) may be protective against cognitive decline. In a Southern Italian elderly population from the Italian Longitudinal Study on Aging (ILSA), a clear reduction of risk of age-related cognitive decline (ARCD) has been found with elevated intake of PUFA and MUFA. Furthermore, in the ILSA, while dietary fatty acids intakes were not associated with incident mild cognitive impairment (MCI), high PUFA intake appeared to have borderline non-significant trend for a protective effect against the development of MCI. These epidemiological findings on predementia syndromes, i.e. MCI or ARCD, together with a recent randomised controlled trial on a possible effect on cognitive and depressive symptoms of omega-3 PUFA supplementation in patients with very mild AD, suggested a possible role of fatty acids intake in maintaining adequate cognitive functioning and possibly in preventing or delaying the onset of dementia. SN - 1279-7707 UR - https://www.unboundmedicine.com/medline/citation/18548175/Dietary_fatty_acids_age_related_cognitive_decline_and_mild_cognitive_impairment_ L2 - https://medlineplus.gov/dietaryfats.html DB - PRIME DP - Unbound Medicine ER -