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The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide.
Diabetologia. 2008 Aug; 51(8):1391-8.D

Abstract

AIMS/HYPOTHESIS

This study is an analysis of the relationship between ultraviolet B (UVB) irradiance, the primary source of circulating vitamin D in humans, and age-standardised incidence rates of type 1 diabetes mellitus in children, according to region of the world.

METHODS

The association of UVB irradiance adjusted for cloud cover to incidence rates of type 1 diabetes in children aged <14 years during 1990--1994 in 51 regions worldwide was assessed using multiple regression. Incidence data were obtained from the Diabetes Mondial Project Group.

RESULTS

Incidence rates were generally higher at higher latitudes (R2 = 0.25, p < 0.001). According to multiple regression, UVB irradiance adjusted for cloud cover was inversely associated with incidence rates (p < 0.05), while per capita health expenditure (p < 0.004) was positively associated (overall R2 = 0.42, p < 0.0001).

CONCLUSIONS/INTERPRETATION

An association was found between low UVB irradiance and high incidence rates of type 1 childhood diabetes after controlling for per capita health expenditure. Incidence rates of type 1 diabetes approached zero in regions worldwide with high UVB irradiance, adding new support to the concept of a role of vitamin D in reducing the risk of the disease.

Authors+Show Affiliations

Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Drive, Mail Code 0631C, La Jolla, CA 92093-0631, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18548227

Citation

Mohr, S B., et al. "The Association Between Ultraviolet B Irradiance, Vitamin D Status and Incidence Rates of Type 1 Diabetes in 51 Regions Worldwide." Diabetologia, vol. 51, no. 8, 2008, pp. 1391-8.
Mohr SB, Garland CF, Gorham ED, et al. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia. 2008;51(8):1391-8.
Mohr, S. B., Garland, C. F., Gorham, E. D., & Garland, F. C. (2008). The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia, 51(8), 1391-8. https://doi.org/10.1007/s00125-008-1061-5
Mohr SB, et al. The Association Between Ultraviolet B Irradiance, Vitamin D Status and Incidence Rates of Type 1 Diabetes in 51 Regions Worldwide. Diabetologia. 2008;51(8):1391-8. PubMed PMID: 18548227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. AU - Mohr,S B, AU - Garland,C F, AU - Gorham,E D, AU - Garland,F C, Y1 - 2008/06/12/ PY - 2007/09/20/received PY - 2008/04/03/accepted PY - 2008/6/13/pubmed PY - 2008/11/19/medline PY - 2008/6/13/entrez SP - 1391 EP - 8 JF - Diabetologia JO - Diabetologia VL - 51 IS - 8 N2 - AIMS/HYPOTHESIS: This study is an analysis of the relationship between ultraviolet B (UVB) irradiance, the primary source of circulating vitamin D in humans, and age-standardised incidence rates of type 1 diabetes mellitus in children, according to region of the world. METHODS: The association of UVB irradiance adjusted for cloud cover to incidence rates of type 1 diabetes in children aged <14 years during 1990--1994 in 51 regions worldwide was assessed using multiple regression. Incidence data were obtained from the Diabetes Mondial Project Group. RESULTS: Incidence rates were generally higher at higher latitudes (R2 = 0.25, p < 0.001). According to multiple regression, UVB irradiance adjusted for cloud cover was inversely associated with incidence rates (p < 0.05), while per capita health expenditure (p < 0.004) was positively associated (overall R2 = 0.42, p < 0.0001). CONCLUSIONS/INTERPRETATION: An association was found between low UVB irradiance and high incidence rates of type 1 childhood diabetes after controlling for per capita health expenditure. Incidence rates of type 1 diabetes approached zero in regions worldwide with high UVB irradiance, adding new support to the concept of a role of vitamin D in reducing the risk of the disease. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/18548227/The_association_between_ultraviolet_B_irradiance_vitamin_D_status_and_incidence_rates_of_type_1_diabetes_in_51_regions_worldwide_ L2 - https://doi.org/10.1007/s00125-008-1061-5 DB - PRIME DP - Unbound Medicine ER -