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High-frequency rTMS over the supplementary motor area for treatment of Parkinson's disease.
Mov Disord. 2008 Aug 15; 23(11):1524-31.MD

Abstract

Dysfunction of the basal ganglia-thalamocortical motor circuit is a fundamental model to account for motor symptoms in Parkinson's disease (PD). Using high-frequency repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA), we investigated whether modulation of SMA excitability engenders therapeutic effects on motor symptoms in PD. In this double-blind placebo-controlled study, 99 patients were enrolled and assigned randomly to SMA-stimulation and sham-stimulation groups. For SMA stimulation, 20 trains of 50 transcranial magnetic stimuli at 5 Hz were delivered at an intensity of 110% active motor threshold for leg muscles in one session. The sham stimulation was 20 trains of electric stimuli given through electrodes fixed on the head to mimic the cutaneous sensation during rTMS. Each session of intervention was carried out once a week for the first 8 weeks. The SMA stimulation, in contrast to the sham stimulation, engendered significant improvements in total scores and motor scores of the Unified Parkinson's Disease Rating Scale. Mean improvements in motor scores were 4.5 points in the SMA-stimulation group and -0.1 points in the sham-stimulation group. Results indicate that 5 Hz rTMS over SMA modestly improves motor symptoms in PD patients; SMA is a potential stimulation site for PD treatment.

Authors+Show Affiliations

Department of Neurology, Division of Neuroscience, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. mhamada-tky@umin.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18548577

Citation

Hamada, Masashi, et al. "High-frequency rTMS Over the Supplementary Motor Area for Treatment of Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23, no. 11, 2008, pp. 1524-31.
Hamada M, Ugawa Y, Tsuji S, et al. High-frequency rTMS over the supplementary motor area for treatment of Parkinson's disease. Mov Disord. 2008;23(11):1524-31.
Hamada, M., Ugawa, Y., & Tsuji, S. (2008). High-frequency rTMS over the supplementary motor area for treatment of Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 23(11), 1524-31. https://doi.org/10.1002/mds.22168
Hamada M, et al. High-frequency rTMS Over the Supplementary Motor Area for Treatment of Parkinson's Disease. Mov Disord. 2008 Aug 15;23(11):1524-31. PubMed PMID: 18548577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-frequency rTMS over the supplementary motor area for treatment of Parkinson's disease. AU - Hamada,Masashi, AU - Ugawa,Yoshikazu, AU - Tsuji,Sadatoshi, AU - ,, PY - 2008/6/13/pubmed PY - 2009/4/9/medline PY - 2008/6/13/entrez SP - 1524 EP - 31 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 23 IS - 11 N2 - Dysfunction of the basal ganglia-thalamocortical motor circuit is a fundamental model to account for motor symptoms in Parkinson's disease (PD). Using high-frequency repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA), we investigated whether modulation of SMA excitability engenders therapeutic effects on motor symptoms in PD. In this double-blind placebo-controlled study, 99 patients were enrolled and assigned randomly to SMA-stimulation and sham-stimulation groups. For SMA stimulation, 20 trains of 50 transcranial magnetic stimuli at 5 Hz were delivered at an intensity of 110% active motor threshold for leg muscles in one session. The sham stimulation was 20 trains of electric stimuli given through electrodes fixed on the head to mimic the cutaneous sensation during rTMS. Each session of intervention was carried out once a week for the first 8 weeks. The SMA stimulation, in contrast to the sham stimulation, engendered significant improvements in total scores and motor scores of the Unified Parkinson's Disease Rating Scale. Mean improvements in motor scores were 4.5 points in the SMA-stimulation group and -0.1 points in the sham-stimulation group. Results indicate that 5 Hz rTMS over SMA modestly improves motor symptoms in PD patients; SMA is a potential stimulation site for PD treatment. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/18548577/High_frequency_rTMS_over_the_supplementary_motor_area_for_treatment_of_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.22168 DB - PRIME DP - Unbound Medicine ER -