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[Determination and clinical implication of leukotriene B(4) and tumor necrosis factor-alpha in condensate of exhaled breath of chronic obstructive pulmonary disease patients].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008 Jun; 20(6):357-60.ZW

Abstract

OBJECTIVE

To study the changes and clinical implication of leukotriene B(4) (LTB(4)) and tumor necrosis factor-alpha (TNF-alpha) in exhaled breath condensate (EBC) of chronic obstructive pulmonary disease (COPD) patients.

METHODS

EBC of 20 patients in acute episode of COPD (AECOPD), 20 patients in period of remission of COPD, and 20 persons who were having regular check-up (healthy control group) were enrolled. The concentrations of LTB(4) and TNF-alpha in EBC were assayed. Forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF) of COPD patients were observed at the same time, pH, oxygenation index (PaO(2)/FiO(2)), partial pressure of oxygen in arterial blood (PaO(2)) and leukocyte count were also determined.

RESULTS

(1)The concentrations of LTB(4) in EBC of AECOPD (35.43+/-14.19)ng/L and remission of COPD(24.39+/-13.75)ng/L, were significantly higher than that of the healthy control group (16.75+/-7.44)ng/L, and the concentration of LTB(4) in EBC during remission of COPD was significantly lower than that of AECOPD (all P<0.05). (2)The concentration of TNF-alpha in EBC of AECOPD (9.35+/-8.66) ng/L was significantly higher than that of remission of COPD (4.42+/-4.11)ng/L and healthy control group (4.45+/-3.92) ng/L, and the differences had statistical significance (both P<0.05). The concentration of TNF-alpha in EBC showed no significant difference between patients in remission of COPD and healthy control group. (3)The concentration of LTB(4) in EBC had negative correlation with FEV1 of AECOPD patients. Regression equation was y=or-0.51 x+0.22, r=-0.481 (P<0.05).

CONCLUSION

The concentrations of LTB4 and TNF-alpha in EBC of AECOPD patients are raised when oxidation stress is reinforced, and its level reflects the severity and prognosis of COPD.

Authors+Show Affiliations

Second Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China. chjr@pub.nt.jsinfo.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

18549718

Citation

Chen, Jin-Liang, et al. "[Determination and Clinical Implication of Leukotriene B(4) and Tumor Necrosis Factor-alpha in Condensate of Exhaled Breath of Chronic Obstructive Pulmonary Disease Patients]." Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, vol. 20, no. 6, 2008, pp. 357-60.
Chen JL, Chen JR, Tao YJ, et al. [Determination and clinical implication of leukotriene B(4) and tumor necrosis factor-alpha in condensate of exhaled breath of chronic obstructive pulmonary disease patients]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008;20(6):357-60.
Chen, J. L., Chen, J. R., Tao, Y. J., Cai, Y. Y., & Tao, G. H. (2008). [Determination and clinical implication of leukotriene B(4) and tumor necrosis factor-alpha in condensate of exhaled breath of chronic obstructive pulmonary disease patients]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 20(6), 357-60.
Chen JL, et al. [Determination and Clinical Implication of Leukotriene B(4) and Tumor Necrosis Factor-alpha in Condensate of Exhaled Breath of Chronic Obstructive Pulmonary Disease Patients]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008;20(6):357-60. PubMed PMID: 18549718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Determination and clinical implication of leukotriene B(4) and tumor necrosis factor-alpha in condensate of exhaled breath of chronic obstructive pulmonary disease patients]. AU - Chen,Jin-Liang, AU - Chen,Jian-Rong, AU - Tao,Yi-Jiang, AU - Cai,Ying-Yun, AU - Tao,Guo-Hua, PY - 2008/6/14/pubmed PY - 2010/2/5/medline PY - 2008/6/14/entrez SP - 357 EP - 60 JF - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue JO - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue VL - 20 IS - 6 N2 - OBJECTIVE: To study the changes and clinical implication of leukotriene B(4) (LTB(4)) and tumor necrosis factor-alpha (TNF-alpha) in exhaled breath condensate (EBC) of chronic obstructive pulmonary disease (COPD) patients. METHODS: EBC of 20 patients in acute episode of COPD (AECOPD), 20 patients in period of remission of COPD, and 20 persons who were having regular check-up (healthy control group) were enrolled. The concentrations of LTB(4) and TNF-alpha in EBC were assayed. Forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF) of COPD patients were observed at the same time, pH, oxygenation index (PaO(2)/FiO(2)), partial pressure of oxygen in arterial blood (PaO(2)) and leukocyte count were also determined. RESULTS: (1)The concentrations of LTB(4) in EBC of AECOPD (35.43+/-14.19)ng/L and remission of COPD(24.39+/-13.75)ng/L, were significantly higher than that of the healthy control group (16.75+/-7.44)ng/L, and the concentration of LTB(4) in EBC during remission of COPD was significantly lower than that of AECOPD (all P<0.05). (2)The concentration of TNF-alpha in EBC of AECOPD (9.35+/-8.66) ng/L was significantly higher than that of remission of COPD (4.42+/-4.11)ng/L and healthy control group (4.45+/-3.92) ng/L, and the differences had statistical significance (both P<0.05). The concentration of TNF-alpha in EBC showed no significant difference between patients in remission of COPD and healthy control group. (3)The concentration of LTB(4) in EBC had negative correlation with FEV1 of AECOPD patients. Regression equation was y=or-0.51 x+0.22, r=-0.481 (P<0.05). CONCLUSION: The concentrations of LTB4 and TNF-alpha in EBC of AECOPD patients are raised when oxidation stress is reinforced, and its level reflects the severity and prognosis of COPD. SN - 1003-0603 UR - https://www.unboundmedicine.com/medline/citation/18549718/[Determination_and_clinical_implication_of_leukotriene_B_4__and_tumor_necrosis_factor_alpha_in_condensate_of_exhaled_breath_of_chronic_obstructive_pulmonary_disease_patients]_ L2 - http://www.diseaseinfosearch.org/result/7979 DB - PRIME DP - Unbound Medicine ER -