Tags

Type your tag names separated by a space and hit enter

Novel cardiovascular risk factors do not completely explain the higher prevalence of peripheral arterial disease among African Americans. The San Diego Population Study.
J Am Coll Cardiol. 2008 Jun 17; 51(24):2347-54.JACC

Abstract

OBJECTIVES

This study was designed to determine whether novel cardiovascular disease (CVD) risk factors explain the high prevalence of peripheral arterial disease (PAD) among African Americans.

BACKGROUND

Compared with Caucasians, African Americans have higher prevalence of PAD, an association that is not explained by traditional CVD risk factors. The degree to which novel CVD risk markers may explain the higher prevalence is uncertain.

METHODS

A nested case-control study within the San Diego Population Study was performed. The study evaluated 104 persons with PAD and 164 age- and gender-matched control subjects who were employees of a large public university and participated in a peripheral artery and venous disease study. Nine novel CVD risk factors (homocysteine, lipoprotein (a), C-reactive protein, fibrinogen, tumor necrosis factor-alpha, von Willebrand factor, prothrombin fragment 1-2, D-dimer, and plasmin antiplasmin) were measured. Multivariable logistic regression evaluated whether these novel factors attenuated the association of African-American race and PAD and whether there was differential ethnic susceptibility to the novel factors.

RESULTS

African Americans had 3-fold higher odds of PAD in age- and gender-matched models (odds ratio [OR] 3.1; 95% confidence interval [CI] 1.5 to 6.4; p < 0.01), an association that was modestly attenuated by adjustment for traditional (OR 2.4; 95% CI 0.9 to 6.1; p = 0.06) and novel CVD risk markers (OR 1.9; 95% CI 0.7 to 4.7; p = 0.18). Among the novel factors, the attenuation was primarily due to fibrinogen and lipoprotein (a). No interactions by novel CVD risk markers (both p values for interaction > or =0.24) were observed.

CONCLUSIONS

Traditional and novel CVD risk factors only partially explain the higher prevalence of PAD among African Americans.

Authors+Show Affiliations

Department of Medicine, University of California, San Diego, San Diego, California 92161, USA. joeix@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18549921

Citation

Ix, Joachim H., et al. "Novel Cardiovascular Risk Factors Do Not Completely Explain the Higher Prevalence of Peripheral Arterial Disease Among African Americans. the San Diego Population Study." Journal of the American College of Cardiology, vol. 51, no. 24, 2008, pp. 2347-54.
Ix JH, Allison MA, Denenberg JO, et al. Novel cardiovascular risk factors do not completely explain the higher prevalence of peripheral arterial disease among African Americans. The San Diego Population Study. J Am Coll Cardiol. 2008;51(24):2347-54.
Ix, J. H., Allison, M. A., Denenberg, J. O., Cushman, M., & Criqui, M. H. (2008). Novel cardiovascular risk factors do not completely explain the higher prevalence of peripheral arterial disease among African Americans. The San Diego Population Study. Journal of the American College of Cardiology, 51(24), 2347-54. https://doi.org/10.1016/j.jacc.2008.03.022
Ix JH, et al. Novel Cardiovascular Risk Factors Do Not Completely Explain the Higher Prevalence of Peripheral Arterial Disease Among African Americans. the San Diego Population Study. J Am Coll Cardiol. 2008 Jun 17;51(24):2347-54. PubMed PMID: 18549921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Novel cardiovascular risk factors do not completely explain the higher prevalence of peripheral arterial disease among African Americans. The San Diego Population Study. AU - Ix,Joachim H, AU - Allison,Matthew A, AU - Denenberg,Julie O, AU - Cushman,Mary, AU - Criqui,Michael H, PY - 2008/01/09/received PY - 2008/02/15/revised PY - 2008/03/17/accepted PY - 2008/6/14/pubmed PY - 2008/7/4/medline PY - 2008/6/14/entrez SP - 2347 EP - 54 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 51 IS - 24 N2 - OBJECTIVES: This study was designed to determine whether novel cardiovascular disease (CVD) risk factors explain the high prevalence of peripheral arterial disease (PAD) among African Americans. BACKGROUND: Compared with Caucasians, African Americans have higher prevalence of PAD, an association that is not explained by traditional CVD risk factors. The degree to which novel CVD risk markers may explain the higher prevalence is uncertain. METHODS: A nested case-control study within the San Diego Population Study was performed. The study evaluated 104 persons with PAD and 164 age- and gender-matched control subjects who were employees of a large public university and participated in a peripheral artery and venous disease study. Nine novel CVD risk factors (homocysteine, lipoprotein (a), C-reactive protein, fibrinogen, tumor necrosis factor-alpha, von Willebrand factor, prothrombin fragment 1-2, D-dimer, and plasmin antiplasmin) were measured. Multivariable logistic regression evaluated whether these novel factors attenuated the association of African-American race and PAD and whether there was differential ethnic susceptibility to the novel factors. RESULTS: African Americans had 3-fold higher odds of PAD in age- and gender-matched models (odds ratio [OR] 3.1; 95% confidence interval [CI] 1.5 to 6.4; p < 0.01), an association that was modestly attenuated by adjustment for traditional (OR 2.4; 95% CI 0.9 to 6.1; p = 0.06) and novel CVD risk markers (OR 1.9; 95% CI 0.7 to 4.7; p = 0.18). Among the novel factors, the attenuation was primarily due to fibrinogen and lipoprotein (a). No interactions by novel CVD risk markers (both p values for interaction > or =0.24) were observed. CONCLUSIONS: Traditional and novel CVD risk factors only partially explain the higher prevalence of PAD among African Americans. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/18549921/Novel_cardiovascular_risk_factors_do_not_completely_explain_the_higher_prevalence_of_peripheral_arterial_disease_among_African_Americans__The_San_Diego_Population_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(08)01132-7 DB - PRIME DP - Unbound Medicine ER -