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Enhancing effect of HT008-1 on cognitive function and quality of life in cognitively declined healthy adults: a randomized, double-blind, placebo-controlled, trial.
Pharmacol Biochem Behav. 2008 Oct; 90(4):517-24.PB

Abstract

HT008-1 is one of the most effective multiherb mixtures that have neuroprotective effects in traditional Korean medicine. The purpose of this study was to conduct a clinical trial of the efficacy of HT008-1 on the neuropsychological functioning and quality of life (QoL) in cognitively intact adults. One hundred and eighteen male (n - 42) and female (n = 76) volunteers who reported no history of dementia or significant neurocognitive impairments and obtained Korean Version of Mini Mental State Examination total scores of at least 24 were examined via an 8-week, randomized, double-blind, fixed-dose, placebo-controlled, parallel group, clinical trial. Participants were randomly assigned to receive either HT008-1 (n = 59) or placebo (n = 59) for 8 weeks. Efficacy measures consisted of participants' performance scores from pretreatment baseline to those obtained just before termination of treatment on standardized neuropsychological measures from the subsets of Wechsler Memory Scale-III (WMS-III). QoL was assessed by subjective questionnaires WHOQoL-Bref about five categories. Participants who scored in the lower third of the Auditory recognition delayed at baseline and received HT008-1 exhibited improvement on the WMS-III Auditory recognition delayed subtest compared with placebo controls. The HT008-1 group also improved on general health scores in the QoL test.

Authors+Show Affiliations

Stress Clinic, Kyung Hee University East-West Neo Medical Center, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18550156

Citation

Kim, Jongwoo, et al. "Enhancing Effect of HT008-1 On Cognitive Function and Quality of Life in Cognitively Declined Healthy Adults: a Randomized, Double-blind, Placebo-controlled, Trial." Pharmacology, Biochemistry, and Behavior, vol. 90, no. 4, 2008, pp. 517-24.
Kim J, Chung SY, Park S, et al. Enhancing effect of HT008-1 on cognitive function and quality of life in cognitively declined healthy adults: a randomized, double-blind, placebo-controlled, trial. Pharmacol Biochem Behav. 2008;90(4):517-24.
Kim, J., Chung, S. Y., Park, S., Park, J. H., Byun, S., Hwang, M., Oh, D. S., Choi, H., Kim, M. Y., Bu, Y. C., Doré, S., Whang, W. W., & Kim, H. (2008). Enhancing effect of HT008-1 on cognitive function and quality of life in cognitively declined healthy adults: a randomized, double-blind, placebo-controlled, trial. Pharmacology, Biochemistry, and Behavior, 90(4), 517-24. https://doi.org/10.1016/j.pbb.2008.03.033
Kim J, et al. Enhancing Effect of HT008-1 On Cognitive Function and Quality of Life in Cognitively Declined Healthy Adults: a Randomized, Double-blind, Placebo-controlled, Trial. Pharmacol Biochem Behav. 2008;90(4):517-24. PubMed PMID: 18550156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhancing effect of HT008-1 on cognitive function and quality of life in cognitively declined healthy adults: a randomized, double-blind, placebo-controlled, trial. AU - Kim,Jongwoo, AU - Chung,Sun Yong, AU - Park,Sojeong, AU - Park,Jong-Hoon, AU - Byun,Soonim, AU - Hwang,Manki, AU - Oh,Dal-Seok, AU - Choi,Hyungsuk, AU - Kim,Mi-Yeon, AU - Bu,Youngmin C, AU - Doré,Sylvain, AU - Whang,Wei-Wan, AU - Kim,Hocheol, PY - 2007/08/30/received PY - 2008/03/15/revised PY - 2008/03/30/accepted PY - 2008/6/14/pubmed PY - 2008/12/17/medline PY - 2008/6/14/entrez SP - 517 EP - 24 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 90 IS - 4 N2 - HT008-1 is one of the most effective multiherb mixtures that have neuroprotective effects in traditional Korean medicine. The purpose of this study was to conduct a clinical trial of the efficacy of HT008-1 on the neuropsychological functioning and quality of life (QoL) in cognitively intact adults. One hundred and eighteen male (n - 42) and female (n = 76) volunteers who reported no history of dementia or significant neurocognitive impairments and obtained Korean Version of Mini Mental State Examination total scores of at least 24 were examined via an 8-week, randomized, double-blind, fixed-dose, placebo-controlled, parallel group, clinical trial. Participants were randomly assigned to receive either HT008-1 (n = 59) or placebo (n = 59) for 8 weeks. Efficacy measures consisted of participants' performance scores from pretreatment baseline to those obtained just before termination of treatment on standardized neuropsychological measures from the subsets of Wechsler Memory Scale-III (WMS-III). QoL was assessed by subjective questionnaires WHOQoL-Bref about five categories. Participants who scored in the lower third of the Auditory recognition delayed at baseline and received HT008-1 exhibited improvement on the WMS-III Auditory recognition delayed subtest compared with placebo controls. The HT008-1 group also improved on general health scores in the QoL test. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/18550156/Enhancing_effect_of_HT008-1_on_cognitive_function_and_quality_of_life_in_cognitively_declined_healthy_adults:_a_randomized,_double-blind,_placebo-controlled,_trial L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(08)00116-0 DB - PRIME DP - Unbound Medicine ER -