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Cytoprotective activity of annphenone against oxidative stress-induced apoptosis in V79-4 lung fibroblast cells.
Cell Biol Int. 2008 Sep; 32(9):1099-107.CB

Abstract

We have elucidated the cytoprotective effect of annphenone (2,4-dihyroxy-6-methoxy-acetophenone 4-O-beta-D-glucopyranoside) against oxidative stress-induced apoptosis. Annphenone scavenged intracellular reactive oxygen species (ROS) and increased antioxidant enzyme activities. It thereby prevented lipid peroxidation and DNA damage, which was demonstrated by the inhibition of the formation of thiobarbituric acid reactive substance (TBARS), inhibition of the comet tail and decreased phospho-H2A.X expression. Annphenone protected Chinese hamster lung fibroblast (V79-4) cells from cell death via the inhibition of apoptosis induced by hydrogen peroxide (H2O2), as shown by decreased apoptotic nuclear fragmentation, decreased sub-G1 cell population and inhibited mitochondrial membrane potential (Deltapsi) loss. Taken together, these findings suggest that annphenone exhibits antioxidant properties by inhibiting ROS generation and thus protecting cells from H2O2-induced cell damage.

Authors+Show Affiliations

Department of Foods and Nutrition, College of Natural Sciences, Duk Sung Women's University, Seoul 132-714, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18550394

Citation

Shin, Jung Sook, et al. "Cytoprotective Activity of Annphenone Against Oxidative Stress-induced Apoptosis in V79-4 Lung Fibroblast Cells." Cell Biology International, vol. 32, no. 9, 2008, pp. 1099-107.
Shin JS, Kang KA, Kim ES, et al. Cytoprotective activity of annphenone against oxidative stress-induced apoptosis in V79-4 lung fibroblast cells. Cell Biol Int. 2008;32(9):1099-107.
Shin, J. S., Kang, K. A., Kim, E. S., Zhang, R., Piao, M. J., Ko, D. O., Wang, Z. H., Maeng, Y. H., Eun, S. Y., Chae, S., Chung, H. S., & Hyun, J. W. (2008). Cytoprotective activity of annphenone against oxidative stress-induced apoptosis in V79-4 lung fibroblast cells. Cell Biology International, 32(9), 1099-107. https://doi.org/10.1016/j.cellbi.2008.04.022
Shin JS, et al. Cytoprotective Activity of Annphenone Against Oxidative Stress-induced Apoptosis in V79-4 Lung Fibroblast Cells. Cell Biol Int. 2008;32(9):1099-107. PubMed PMID: 18550394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytoprotective activity of annphenone against oxidative stress-induced apoptosis in V79-4 lung fibroblast cells. AU - Shin,Jung Sook, AU - Kang,Kyoung Ah, AU - Kim,Eun Sil, AU - Zhang,Rui, AU - Piao,Mei Jing, AU - Ko,Dong Ok, AU - Wang,Zhi Hong, AU - Maeng,Young Hee, AU - Eun,Su Yong, AU - Chae,Sungwook, AU - Chung,Ha Sook, AU - Hyun,Jin Won, Y1 - 2008/05/02/ PY - 2008/01/24/received PY - 2008/02/27/revised PY - 2008/04/25/accepted PY - 2008/6/14/pubmed PY - 2008/11/11/medline PY - 2008/6/14/entrez SP - 1099 EP - 107 JF - Cell biology international JO - Cell Biol Int VL - 32 IS - 9 N2 - We have elucidated the cytoprotective effect of annphenone (2,4-dihyroxy-6-methoxy-acetophenone 4-O-beta-D-glucopyranoside) against oxidative stress-induced apoptosis. Annphenone scavenged intracellular reactive oxygen species (ROS) and increased antioxidant enzyme activities. It thereby prevented lipid peroxidation and DNA damage, which was demonstrated by the inhibition of the formation of thiobarbituric acid reactive substance (TBARS), inhibition of the comet tail and decreased phospho-H2A.X expression. Annphenone protected Chinese hamster lung fibroblast (V79-4) cells from cell death via the inhibition of apoptosis induced by hydrogen peroxide (H2O2), as shown by decreased apoptotic nuclear fragmentation, decreased sub-G1 cell population and inhibited mitochondrial membrane potential (Deltapsi) loss. Taken together, these findings suggest that annphenone exhibits antioxidant properties by inhibiting ROS generation and thus protecting cells from H2O2-induced cell damage. SN - 1065-6995 UR - https://www.unboundmedicine.com/medline/citation/18550394/Cytoprotective_activity_of_annphenone_against_oxidative_stress_induced_apoptosis_in_V79_4_lung_fibroblast_cells_ L2 - https://doi.org/10.1016/j.cellbi.2008.04.022 DB - PRIME DP - Unbound Medicine ER -