Tags

Type your tag names separated by a space and hit enter

Patient and graft outcomes from deceased kidney donors age 70 years and older: an analysis of the Organ Procurement Transplant Network/United Network of Organ Sharing database.
Transplantation. 2008 Jun 15; 85(11):1573-9.T

Abstract

BACKGROUND

The organ shortage has resulted in more use of older deceased donor kidneys. Data are limited on the impact of donor aged 70 years and older on transplant outcomes. We examined patient and graft outcomes of renal transplant from expanded criteria donors (ECDs) aged 70 years and older, using the Organ Procurement Transplant Network/United Network of Organ Sharing database.

METHODS

We identified 601 deceased donor transplants from donors older than 70 years from 2000 to 2005. The follow-up time was until May 2007. Allograft and patient survival were compared between recipients of transplants from older ECDs (age > or =70) and younger ECDs (age 50-69). The relative risk of graft loss and patient death were determined using multivariate models.

RESULTS

The adjusted relative risks of overall graft loss (hazards ratio [HR] 1.37; 95% confidence interval [CI] 1.19-1.58), death-censored graft loss (HR 1.32; 95% CI 1.09-1.61), and patient death (HR 1.37; 95% CI 1.15-1.64) were greater among recipients of transplants from older ECD kidneys. The relative risk of patient death was lower when older ECD kidneys were transplanted into recipients older than 60 compared with recipients aged 41 to 60. In contrast, the relative risk of death-censored graft loss was not increased when older ECD kidneys were transplanted into recipients older than 60.

CONCLUSIONS

Transplants from older ECD kidneys are associated with a higher risk of graft loss and patient death. The risk was highest when older ECD kidneys were transplanted into recipients younger than 60 years.

Authors+Show Affiliations

Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

18551062

Citation

Chavalitdhamrong, Disaya, et al. "Patient and Graft Outcomes From Deceased Kidney Donors Age 70 Years and Older: an Analysis of the Organ Procurement Transplant Network/United Network of Organ Sharing Database." Transplantation, vol. 85, no. 11, 2008, pp. 1573-9.
Chavalitdhamrong D, Gill J, Takemoto S, et al. Patient and graft outcomes from deceased kidney donors age 70 years and older: an analysis of the Organ Procurement Transplant Network/United Network of Organ Sharing database. Transplantation. 2008;85(11):1573-9.
Chavalitdhamrong, D., Gill, J., Takemoto, S., Madhira, B. R., Cho, Y. W., Shah, T., & Bunnapradist, S. (2008). Patient and graft outcomes from deceased kidney donors age 70 years and older: an analysis of the Organ Procurement Transplant Network/United Network of Organ Sharing database. Transplantation, 85(11), 1573-9. https://doi.org/10.1097/TP.0b013e31817059a1
Chavalitdhamrong D, et al. Patient and Graft Outcomes From Deceased Kidney Donors Age 70 Years and Older: an Analysis of the Organ Procurement Transplant Network/United Network of Organ Sharing Database. Transplantation. 2008 Jun 15;85(11):1573-9. PubMed PMID: 18551062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Patient and graft outcomes from deceased kidney donors age 70 years and older: an analysis of the Organ Procurement Transplant Network/United Network of Organ Sharing database. AU - Chavalitdhamrong,Disaya, AU - Gill,Jagbir, AU - Takemoto,Steve, AU - Madhira,Bhaskara R, AU - Cho,Yong W, AU - Shah,Tariq, AU - Bunnapradist,Suphamai, PY - 2008/6/14/pubmed PY - 2008/7/17/medline PY - 2008/6/14/entrez SP - 1573 EP - 9 JF - Transplantation JO - Transplantation VL - 85 IS - 11 N2 - BACKGROUND: The organ shortage has resulted in more use of older deceased donor kidneys. Data are limited on the impact of donor aged 70 years and older on transplant outcomes. We examined patient and graft outcomes of renal transplant from expanded criteria donors (ECDs) aged 70 years and older, using the Organ Procurement Transplant Network/United Network of Organ Sharing database. METHODS: We identified 601 deceased donor transplants from donors older than 70 years from 2000 to 2005. The follow-up time was until May 2007. Allograft and patient survival were compared between recipients of transplants from older ECDs (age > or =70) and younger ECDs (age 50-69). The relative risk of graft loss and patient death were determined using multivariate models. RESULTS: The adjusted relative risks of overall graft loss (hazards ratio [HR] 1.37; 95% confidence interval [CI] 1.19-1.58), death-censored graft loss (HR 1.32; 95% CI 1.09-1.61), and patient death (HR 1.37; 95% CI 1.15-1.64) were greater among recipients of transplants from older ECD kidneys. The relative risk of patient death was lower when older ECD kidneys were transplanted into recipients older than 60 compared with recipients aged 41 to 60. In contrast, the relative risk of death-censored graft loss was not increased when older ECD kidneys were transplanted into recipients older than 60. CONCLUSIONS: Transplants from older ECD kidneys are associated with a higher risk of graft loss and patient death. The risk was highest when older ECD kidneys were transplanted into recipients younger than 60 years. SN - 0041-1337 UR - https://www.unboundmedicine.com/medline/citation/18551062/Patient_and_graft_outcomes_from_deceased_kidney_donors_age_70_years_and_older:_an_analysis_of_the_Organ_Procurement_Transplant_Network/United_Network_of_Organ_Sharing_database_ L2 - https://doi.org/10.1097/TP.0b013e31817059a1 DB - PRIME DP - Unbound Medicine ER -