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A randomized, placebo-controlled trial of the effects of physical exercises and estrogen therapy on health-related quality of life in postmenopausal women.
Menopause. 2008 Jul-Aug; 15(4 Pt 1):613-8.M

Abstract

OBJECTIVE

The purpose of this study was to evaluate the isolated and associated effects of estrogen therapy (estradiol valerate 1 mg/d orally) and physical exercise (moderate aerobic exercise, 3 h/wk) on health-related quality of life (HRQOL) and menopausal symptoms among women who had undergone hysterectomy.

DESIGN

A 6-month, randomized, double-blind, placebo-controlled clinical trial with 44 postmenopausal women who had undergone hysterectomy. The interventions were physical exercise and hormone therapy (n = 9), being sedentary and hormone therapy (n = 14), physical exercise and placebo (n = 11), and being sedentary and placebo (n = 10). HRQOL was assessed by a Brazilian standard version of the Medical Outcome Study Short-Form Health Survey and symptoms by Kupperman Index at baseline and after 6 months.

RESULTS

There was a decrease in symptoms in all groups, but only groups who performed physical exercise showed an increase in quality of life. Analysis of variance showed that changes in physical functioning (P = 0.001) and bodily pain (P = 0.012) scores over the 6-month period differed significantly between women who exercised and women who were sedentary, regardless of hormone therapy. Hormone therapy had no effect, and there was also no significant association between physical exercise and hormone therapy in HRQOL.

CONCLUSIONS

Physical exercises can reduce menopausal symptoms and enhance HRQOL, independent of whether hormone therapy is taken.

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Authors+Show Affiliations

Moriyama CK
Hypertension Unit, General Hospital, Sao Paulo, Brazil. ck.moriyama@uol.com.br
Oneda B
No affiliation info available
Bernardo FR
No affiliation info available
Cardoso CG
No affiliation info available
Forjaz CL
No affiliation info available
Abrahao SB
No affiliation info available
Mion D
No affiliation info available
Fonseca AM
No affiliation info available
Tinucci T
No affiliation info available

MeSH

Double-Blind MethodEstrogen Replacement TherapyExerciseFemaleHealth StatusHumansHysterectomyMiddle AgedPostmenopauseQuality of Life

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18551087

Citation

Moriyama, Carolina Kimie, et al. "A Randomized, Placebo-controlled Trial of the Effects of Physical Exercises and Estrogen Therapy On Health-related Quality of Life in Postmenopausal Women." Menopause (New York, N.Y.), vol. 15, no. 4 Pt 1, 2008, pp. 613-8.
Moriyama CK, Oneda B, Bernardo FR, et al. A randomized, placebo-controlled trial of the effects of physical exercises and estrogen therapy on health-related quality of life in postmenopausal women. Menopause. 2008;15(4 Pt 1):613-8.
Moriyama, C. K., Oneda, B., Bernardo, F. R., Cardoso, C. G., Forjaz, C. L., Abrahao, S. B., Mion, D., Fonseca, A. M., & Tinucci, T. (2008). A randomized, placebo-controlled trial of the effects of physical exercises and estrogen therapy on health-related quality of life in postmenopausal women. Menopause (New York, N.Y.), 15(4 Pt 1), 613-8. https://doi.org/10.1097/gme.0b013e3181605494
Moriyama CK, et al. A Randomized, Placebo-controlled Trial of the Effects of Physical Exercises and Estrogen Therapy On Health-related Quality of Life in Postmenopausal Women. Menopause. 2008 Jul-Aug;15(4 Pt 1):613-8. PubMed PMID: 18551087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized, placebo-controlled trial of the effects of physical exercises and estrogen therapy on health-related quality of life in postmenopausal women. AU - Moriyama,Carolina Kimie, AU - Oneda,Bruna, AU - Bernardo,Fernanda Rocchi, AU - Cardoso,Crivaldo Gomes,Jr AU - Forjaz,Claudia L M, AU - Abrahao,Sandra B, AU - Mion,Décio,Jr AU - Fonseca,Angela M, AU - Tinucci,Tais, PY - 2008/6/14/pubmed PY - 2008/9/16/medline PY - 2008/6/14/entrez SP - 613 EP - 8 JF - Menopause (New York, N.Y.) JO - Menopause VL - 15 IS - 4 Pt 1 N2 - OBJECTIVE: The purpose of this study was to evaluate the isolated and associated effects of estrogen therapy (estradiol valerate 1 mg/d orally) and physical exercise (moderate aerobic exercise, 3 h/wk) on health-related quality of life (HRQOL) and menopausal symptoms among women who had undergone hysterectomy. DESIGN: A 6-month, randomized, double-blind, placebo-controlled clinical trial with 44 postmenopausal women who had undergone hysterectomy. The interventions were physical exercise and hormone therapy (n = 9), being sedentary and hormone therapy (n = 14), physical exercise and placebo (n = 11), and being sedentary and placebo (n = 10). HRQOL was assessed by a Brazilian standard version of the Medical Outcome Study Short-Form Health Survey and symptoms by Kupperman Index at baseline and after 6 months. RESULTS: There was a decrease in symptoms in all groups, but only groups who performed physical exercise showed an increase in quality of life. Analysis of variance showed that changes in physical functioning (P = 0.001) and bodily pain (P = 0.012) scores over the 6-month period differed significantly between women who exercised and women who were sedentary, regardless of hormone therapy. Hormone therapy had no effect, and there was also no significant association between physical exercise and hormone therapy in HRQOL. CONCLUSIONS: Physical exercises can reduce menopausal symptoms and enhance HRQOL, independent of whether hormone therapy is taken. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/18551087/A_randomized_placebo_controlled_trial_of_the_effects_of_physical_exercises_and_estrogen_therapy_on_health_related_quality_of_life_in_postmenopausal_women_ L2 - https://doi.org/10.1097/gme.0b013e3181605494 DB - PRIME DP - Unbound Medicine ER -
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