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Predictive value of prehypertension for metabolic syndrome, diabetes, and coronary heart disease among Turks.
Am J Hypertens. 2008 Aug; 21(8):890-5.AJ

Abstract

BACKGROUND

Predictors of prehypertension and the latter's significance in predicting metabolic syndrome (MetS), type 2 diabetes (DM), and incident coronary heart disease (CHD) need further exploration.

METHODS

Individuals with or without prehypertension (blood pressure (BP) 120-139 systolic or 80-89 mm Hg diastolic) were studied prospectively in a representative sample of Turkish adults.

RESULTS

Mean age of 1,501 men and 1,533 women was 48 +/- 12 years at baseline. Prehypertension, identified in 32.8% of the sample, differed from the normotensive group mainly by age-adjusted obesity measures and C-reactive protein (CRP) and progressed to hypertension at more than twofold annual incidence as normotension did. In logistic regression analysis, adjusted for sex, age, heart rate, and smoking status, prehypertension was predictive for risk of MetS in both genders (relative risk (RR) 1.55 (95% confidence interval (CI) 1.21; 1.99)) compared with normotensives. However, DM and CHD were significantly predicted by prehypertension only in women (RR 2.06 and 1.98, respectively, for outcomes). Cardiometabolic risks in women were largely independent of obesity. Body mass index (BMI) at baseline predicted significantly subsequent development of new prehypertension in both genders (hazard ratio 1.39 (95% CI 1.17; 1.65)) and CRP tended to contribute to this risk.

CONCLUSIONS

Prehypertension, compared with normotension, approximately doubles the risk for DM, MetS, and CHD in women without conferring substantial risk in Turkish men, except toward MetS. Excess cardiometabolic risk of prehypertension in women is independent of obesity. BMI is a determinant of prehypertension.

Authors+Show Affiliations

Turkish Society of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey. alt_onat@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18551102

Citation

Onat, Altan, et al. "Predictive Value of Prehypertension for Metabolic Syndrome, Diabetes, and Coronary Heart Disease Among Turks." American Journal of Hypertension, vol. 21, no. 8, 2008, pp. 890-5.
Onat A, Yazici M, Can G, et al. Predictive value of prehypertension for metabolic syndrome, diabetes, and coronary heart disease among Turks. Am J Hypertens. 2008;21(8):890-5.
Onat, A., Yazici, M., Can, G., Kaya, Z., Bulur, S., & Hergenç, G. (2008). Predictive value of prehypertension for metabolic syndrome, diabetes, and coronary heart disease among Turks. American Journal of Hypertension, 21(8), 890-5. https://doi.org/10.1038/ajh.2008.212
Onat A, et al. Predictive Value of Prehypertension for Metabolic Syndrome, Diabetes, and Coronary Heart Disease Among Turks. Am J Hypertens. 2008;21(8):890-5. PubMed PMID: 18551102.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive value of prehypertension for metabolic syndrome, diabetes, and coronary heart disease among Turks. AU - Onat,Altan, AU - Yazici,Mehmet, AU - Can,Günay, AU - Kaya,Zekeriya, AU - Bulur,Serkan, AU - Hergenç,Gülay, Y1 - 2008/06/12/ PY - 2008/6/14/pubmed PY - 2009/1/10/medline PY - 2008/6/14/entrez SP - 890 EP - 5 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 21 IS - 8 N2 - BACKGROUND: Predictors of prehypertension and the latter's significance in predicting metabolic syndrome (MetS), type 2 diabetes (DM), and incident coronary heart disease (CHD) need further exploration. METHODS: Individuals with or without prehypertension (blood pressure (BP) 120-139 systolic or 80-89 mm Hg diastolic) were studied prospectively in a representative sample of Turkish adults. RESULTS: Mean age of 1,501 men and 1,533 women was 48 +/- 12 years at baseline. Prehypertension, identified in 32.8% of the sample, differed from the normotensive group mainly by age-adjusted obesity measures and C-reactive protein (CRP) and progressed to hypertension at more than twofold annual incidence as normotension did. In logistic regression analysis, adjusted for sex, age, heart rate, and smoking status, prehypertension was predictive for risk of MetS in both genders (relative risk (RR) 1.55 (95% confidence interval (CI) 1.21; 1.99)) compared with normotensives. However, DM and CHD were significantly predicted by prehypertension only in women (RR 2.06 and 1.98, respectively, for outcomes). Cardiometabolic risks in women were largely independent of obesity. Body mass index (BMI) at baseline predicted significantly subsequent development of new prehypertension in both genders (hazard ratio 1.39 (95% CI 1.17; 1.65)) and CRP tended to contribute to this risk. CONCLUSIONS: Prehypertension, compared with normotension, approximately doubles the risk for DM, MetS, and CHD in women without conferring substantial risk in Turkish men, except toward MetS. Excess cardiometabolic risk of prehypertension in women is independent of obesity. BMI is a determinant of prehypertension. SN - 0895-7061 UR - https://www.unboundmedicine.com/medline/citation/18551102/Predictive_value_of_prehypertension_for_metabolic_syndrome_diabetes_and_coronary_heart_disease_among_Turks_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1038/ajh.2008.212 DB - PRIME DP - Unbound Medicine ER -