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The detection and characterization of hepatitis E virus in pig livers from retail markets of India.
J Med Virol. 2008 Aug; 80(8):1387-90.JM

Abstract

The zoonotic transmission of Hepatitis E virus (HEV) is a well-established fact and pigs are known reservoirs of the virus. The human and swine HEV from countries such as the USA, Japan and Taiwan, show a remarkable sequence identity. Swine liver samples from markets in Japan and US were shown to be HEV RNA positive. In contrast, in India, viruses belonging to different genotypes, that is, genotypes 1 and 4 circulate in humans and pigs respectively, at least for the last 20 years. To assess possible exposure of the Indian population to swine HEV, 240 pig liver samples were collected from retail markets of Pune, western India. Two (0.83%) samples were found positive for HEV RNA by nested RT-PCR. Nucleotide sequence-based phylogenetic analysis showed the presence of genotype 4 HEV with 90-91% similarity and clustering with Indian swine HEV sequences generated earlier. The data suggest the possibility of HEV infection in persons consuming infected pig liver. So far, it has not been possible to detect any type 4 HEV infection in humans. The absence of type 4 infections in humans may be attributed to cooking leading to the inactivation of the virus.

Authors+Show Affiliations

Hepatitis Division, National Institute of Virology, Pashan, Pune, India.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18551611

Citation

Kulkarni, M A., and V A. Arankalle. "The Detection and Characterization of Hepatitis E Virus in Pig Livers From Retail Markets of India." Journal of Medical Virology, vol. 80, no. 8, 2008, pp. 1387-90.
Kulkarni MA, Arankalle VA. The detection and characterization of hepatitis E virus in pig livers from retail markets of India. J Med Virol. 2008;80(8):1387-90.
Kulkarni, M. A., & Arankalle, V. A. (2008). The detection and characterization of hepatitis E virus in pig livers from retail markets of India. Journal of Medical Virology, 80(8), 1387-90. https://doi.org/10.1002/jmv.21220
Kulkarni MA, Arankalle VA. The Detection and Characterization of Hepatitis E Virus in Pig Livers From Retail Markets of India. J Med Virol. 2008;80(8):1387-90. PubMed PMID: 18551611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The detection and characterization of hepatitis E virus in pig livers from retail markets of India. AU - Kulkarni,M A, AU - Arankalle,V A, PY - 2008/6/14/pubmed PY - 2008/8/30/medline PY - 2008/6/14/entrez SP - 1387 EP - 90 JF - Journal of medical virology JO - J Med Virol VL - 80 IS - 8 N2 - The zoonotic transmission of Hepatitis E virus (HEV) is a well-established fact and pigs are known reservoirs of the virus. The human and swine HEV from countries such as the USA, Japan and Taiwan, show a remarkable sequence identity. Swine liver samples from markets in Japan and US were shown to be HEV RNA positive. In contrast, in India, viruses belonging to different genotypes, that is, genotypes 1 and 4 circulate in humans and pigs respectively, at least for the last 20 years. To assess possible exposure of the Indian population to swine HEV, 240 pig liver samples were collected from retail markets of Pune, western India. Two (0.83%) samples were found positive for HEV RNA by nested RT-PCR. Nucleotide sequence-based phylogenetic analysis showed the presence of genotype 4 HEV with 90-91% similarity and clustering with Indian swine HEV sequences generated earlier. The data suggest the possibility of HEV infection in persons consuming infected pig liver. So far, it has not been possible to detect any type 4 HEV infection in humans. The absence of type 4 infections in humans may be attributed to cooking leading to the inactivation of the virus. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/18551611/The_detection_and_characterization_of_hepatitis_E_virus_in_pig_livers_from_retail_markets_of_India_ L2 - https://doi.org/10.1002/jmv.21220 DB - PRIME DP - Unbound Medicine ER -