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Soluble transferrin receptor, ferritin and soluble transferrin receptor--Ferritin index in assessment of anaemia in rhaeumatoid arthritis.
Med J Malaysia. 2007 Oct; 62(4):303-7.MJ

Abstract

Anaemia of chronic disease (ACD) is a frequent complication of rheumatoid arthritis (RA). A diagnostic difficulty in RA is the distinction between iron deficiency anaemia (IDA) and ACD. The aim of our study was to evaluate the usefulness of serum soluble transferrin receptor (sTfR) and sTfR/log ferritin (TfR-F) index to diagnose iron deficiency in RA patients with anaemia. Routine laboratory indices of anaemia and sTfR were measured in 20 healthy persons to form the control group, 30 patients with iron deficiency anaemia and 28 RA patients with anaemia. Serum sTfR levels were significantly elevated above the cut-off value in patients with IDA and those in the iron depleted RA subgroup (ferritin < 60 microg/L) compared with those in the control and iron repleted RA subgroup (ferritin > 60 microg/L). The same was observed for TfR-F index. However, five patients in the iron repleted RA sub group had an elevated sTfR level, of which two had increased TfR-F index. Serum sTfR correlated well with the markers of anaemia and not with ESR. Ferritin had no correlation with markers of anaemia but correlated well with ESR. Measurement of sTfR and TfR-F index are good indicators of iron deficiency in RA patients with anaemia. To be cost effective, sTfR can be estimated in RA patients with anaemia when the ferritin level is more than 60 microg/L.

Authors+Show Affiliations

Chemical Pathology Unit, Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur. pavai@um.edu.myNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18551934

Citation

Pavai, S, et al. "Soluble Transferrin Receptor, Ferritin and Soluble Transferrin receptor--Ferritin Index in Assessment of Anaemia in Rhaeumatoid Arthritis." The Medical Journal of Malaysia, vol. 62, no. 4, 2007, pp. 303-7.
Pavai S, Jayaranee S, Sargunan S. Soluble transferrin receptor, ferritin and soluble transferrin receptor--Ferritin index in assessment of anaemia in rhaeumatoid arthritis. Med J Malaysia. 2007;62(4):303-7.
Pavai, S., Jayaranee, S., & Sargunan, S. (2007). Soluble transferrin receptor, ferritin and soluble transferrin receptor--Ferritin index in assessment of anaemia in rhaeumatoid arthritis. The Medical Journal of Malaysia, 62(4), 303-7.
Pavai S, Jayaranee S, Sargunan S. Soluble Transferrin Receptor, Ferritin and Soluble Transferrin receptor--Ferritin Index in Assessment of Anaemia in Rhaeumatoid Arthritis. Med J Malaysia. 2007;62(4):303-7. PubMed PMID: 18551934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble transferrin receptor, ferritin and soluble transferrin receptor--Ferritin index in assessment of anaemia in rhaeumatoid arthritis. AU - Pavai,S, AU - Jayaranee,S, AU - Sargunan,S, PY - 2008/6/17/pubmed PY - 2008/8/2/medline PY - 2008/6/17/entrez SP - 303 EP - 7 JF - The Medical journal of Malaysia JO - Med. J. Malaysia VL - 62 IS - 4 N2 - Anaemia of chronic disease (ACD) is a frequent complication of rheumatoid arthritis (RA). A diagnostic difficulty in RA is the distinction between iron deficiency anaemia (IDA) and ACD. The aim of our study was to evaluate the usefulness of serum soluble transferrin receptor (sTfR) and sTfR/log ferritin (TfR-F) index to diagnose iron deficiency in RA patients with anaemia. Routine laboratory indices of anaemia and sTfR were measured in 20 healthy persons to form the control group, 30 patients with iron deficiency anaemia and 28 RA patients with anaemia. Serum sTfR levels were significantly elevated above the cut-off value in patients with IDA and those in the iron depleted RA subgroup (ferritin < 60 microg/L) compared with those in the control and iron repleted RA subgroup (ferritin > 60 microg/L). The same was observed for TfR-F index. However, five patients in the iron repleted RA sub group had an elevated sTfR level, of which two had increased TfR-F index. Serum sTfR correlated well with the markers of anaemia and not with ESR. Ferritin had no correlation with markers of anaemia but correlated well with ESR. Measurement of sTfR and TfR-F index are good indicators of iron deficiency in RA patients with anaemia. To be cost effective, sTfR can be estimated in RA patients with anaemia when the ferritin level is more than 60 microg/L. SN - 0300-5283 UR - https://www.unboundmedicine.com/medline/citation/18551934/Soluble_transferrin_receptor_ferritin_and_soluble_transferrin_receptor__Ferritin_index_in_assessment_of_anaemia_in_rhaeumatoid_arthritis_ L2 - http://www.e-mjm.org/2007/v62n4/Anaemia_Rhaeumatoid_Arthritis.pdf DB - PRIME DP - Unbound Medicine ER -