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Surgical intervention and accommodative responses, II: forward ciliary body accommodative movement is facilitated by zonular attachments to the lens capsule.
Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5495-502.IO

Abstract

PURPOSE

To determine the role of the lens and the lens capsule in the three-dimensional architecture of the ciliary muscle at rest and during accommodation, in live rhesus monkeys and in histologic sections, by removing the entire lens, or only the lens nucleus and cortex, while leaving the posterior capsule in place.

METHODS

In 15 rhesus monkey eyes, aged 6 to 27 years, accommodation was induced by central stimulation of the Edinger-Westphal nucleus before and after intra- or extracapsular lens extraction (ICLE, ECLE). Forward ciliary body movement and ciliary body width were measured by ultrasound biomicroscopy (UBM, 50 MHz). The monkeys were then killed, the eyes were examined morphologically in 1-microm sections, and the shape of the ciliary muscle was compared with that obtained from UBM images.

RESULTS

The shape of the ciliary muscle in eyes undergoing ECLE (n = 5) did not differ from that in control eyes. In contrast, after ICLE (n = 10), accommodative forward ciliary body movement (P < 0.01) and thickness were decreased (P < 0.001), length was increased (P = 0.058), and the inner apex was located more posteriorly than in control eyes (P < 0.005). Histologic and in vivo data were similar and showed that the ciliary muscle maintained its triangular shape only if the lens capsule (with or without the lens substance) was present.

CONCLUSIONS

The posterior lens capsule and anterior zonular attachments facilitate forward accommodative ciliary body movement. Lens substance extraction procedures that leave the posterior capsule intact, similar to those used clinically, do not affect the capsule/zonular/muscular system movements, an important finding for accommodating intraocular lens development.

Authors+Show Affiliations

Department of Anatomy, University of Erlangen-Nürnberg, Erlangen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18552391

Citation

Wasilewski, Rainer, et al. "Surgical Intervention and Accommodative Responses, II: Forward Ciliary Body Accommodative Movement Is Facilitated By Zonular Attachments to the Lens Capsule." Investigative Ophthalmology & Visual Science, vol. 49, no. 12, 2008, pp. 5495-502.
Wasilewski R, McDonald JP, Heatley G, et al. Surgical intervention and accommodative responses, II: forward ciliary body accommodative movement is facilitated by zonular attachments to the lens capsule. Invest Ophthalmol Vis Sci. 2008;49(12):5495-502.
Wasilewski, R., McDonald, J. P., Heatley, G., Lütjen-Drecoll, E., Kaufman, P. L., & Croft, M. A. (2008). Surgical intervention and accommodative responses, II: forward ciliary body accommodative movement is facilitated by zonular attachments to the lens capsule. Investigative Ophthalmology & Visual Science, 49(12), 5495-502. https://doi.org/10.1167/iovs.08-1917
Wasilewski R, et al. Surgical Intervention and Accommodative Responses, II: Forward Ciliary Body Accommodative Movement Is Facilitated By Zonular Attachments to the Lens Capsule. Invest Ophthalmol Vis Sci. 2008;49(12):5495-502. PubMed PMID: 18552391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgical intervention and accommodative responses, II: forward ciliary body accommodative movement is facilitated by zonular attachments to the lens capsule. AU - Wasilewski,Rainer, AU - McDonald,Jared P, AU - Heatley,Gregg, AU - Lütjen-Drecoll,Elke, AU - Kaufman,Paul L, AU - Croft,Mary Ann, Y1 - 2008/06/14/ PY - 2008/6/17/pubmed PY - 2008/12/23/medline PY - 2008/6/17/entrez SP - 5495 EP - 502 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 49 IS - 12 N2 - PURPOSE: To determine the role of the lens and the lens capsule in the three-dimensional architecture of the ciliary muscle at rest and during accommodation, in live rhesus monkeys and in histologic sections, by removing the entire lens, or only the lens nucleus and cortex, while leaving the posterior capsule in place. METHODS: In 15 rhesus monkey eyes, aged 6 to 27 years, accommodation was induced by central stimulation of the Edinger-Westphal nucleus before and after intra- or extracapsular lens extraction (ICLE, ECLE). Forward ciliary body movement and ciliary body width were measured by ultrasound biomicroscopy (UBM, 50 MHz). The monkeys were then killed, the eyes were examined morphologically in 1-microm sections, and the shape of the ciliary muscle was compared with that obtained from UBM images. RESULTS: The shape of the ciliary muscle in eyes undergoing ECLE (n = 5) did not differ from that in control eyes. In contrast, after ICLE (n = 10), accommodative forward ciliary body movement (P < 0.01) and thickness were decreased (P < 0.001), length was increased (P = 0.058), and the inner apex was located more posteriorly than in control eyes (P < 0.005). Histologic and in vivo data were similar and showed that the ciliary muscle maintained its triangular shape only if the lens capsule (with or without the lens substance) was present. CONCLUSIONS: The posterior lens capsule and anterior zonular attachments facilitate forward accommodative ciliary body movement. Lens substance extraction procedures that leave the posterior capsule intact, similar to those used clinically, do not affect the capsule/zonular/muscular system movements, an important finding for accommodating intraocular lens development. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/18552391/Surgical_intervention_and_accommodative_responses_II:_forward_ciliary_body_accommodative_movement_is_facilitated_by_zonular_attachments_to_the_lens_capsule_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.08-1917 DB - PRIME DP - Unbound Medicine ER -