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Surgical intervention and accommodative responses, I: centripetal ciliary body, capsule, and lens movements in rhesus monkeys of various ages.
Invest Ophthalmol Vis Sci 2008; 49(12):5484-94IO

Abstract

PURPOSE

To determine how surgically altering the normal relationship between the lens and the ciliary body in rhesus monkeys affects centripetal ciliary body and lens movement.

METHODS

In 18 rhesus monkey eyes (aged 6-27 years), accommodation was induced before and after surgery by electrical stimulation of the Edinger-Westphal nucleus. Accommodative amplitude was measured by coincidence refractometry. Goniovideography was performed before and after intra- and extracapsular lens extraction (ICLE, ECLE) and anterior regional zonulolysis (ARZ). Centripetal lens/capsule movements, centripetal ciliary process (CP) movements, and circumlental space were measured by computerized image analysis of the goniovideography images.

RESULTS

Centripetal accommodative CP and capsule movement increased in velocity and amplitude after, compared with before, ECLE regardless of age (n = 5). The presence of the lens substance retarded capsule movement by approximately 21% in the young eyes and by approximately 62% in the older eyes. Post-ICLE compared with pre-ICLE centripetal accommodative CP movement was dampened in all eyes in which the anterior vitreous was disrupted (n = 7), but not in eyes in which the anterior vitreous was left intact (n = 2). After anterior regional zonulolysis (n = 4), lens position shifted toward the lysed quadrant during accommodation.

CONCLUSIONS

The presence of the lens substance, capsule zonular attachments, and Wieger's ligament may play a role in centripetal CP movement. The capsule is still capable of centripetal movement in the older eye (although at a reduced capacity) and may have the ability to produce approximately 6 D of accommodation in the presence of a normal, young crystalline lens or a similar surrogate.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA. macroft@wisc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18552393

Citation

Croft, Mary Ann, et al. "Surgical Intervention and Accommodative Responses, I: Centripetal Ciliary Body, Capsule, and Lens Movements in Rhesus Monkeys of Various Ages." Investigative Ophthalmology & Visual Science, vol. 49, no. 12, 2008, pp. 5484-94.
Croft MA, McDonald JP, James RJ, et al. Surgical intervention and accommodative responses, I: centripetal ciliary body, capsule, and lens movements in rhesus monkeys of various ages. Invest Ophthalmol Vis Sci. 2008;49(12):5484-94.
Croft, M. A., McDonald, J. P., James, R. J., Heatley, G. A., Lin, T. L., Lütjen-Drecoll, E., & Kaufman, P. L. (2008). Surgical intervention and accommodative responses, I: centripetal ciliary body, capsule, and lens movements in rhesus monkeys of various ages. Investigative Ophthalmology & Visual Science, 49(12), pp. 5484-94. doi:10.1167/iovs.08-1916.
Croft MA, et al. Surgical Intervention and Accommodative Responses, I: Centripetal Ciliary Body, Capsule, and Lens Movements in Rhesus Monkeys of Various Ages. Invest Ophthalmol Vis Sci. 2008;49(12):5484-94. PubMed PMID: 18552393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgical intervention and accommodative responses, I: centripetal ciliary body, capsule, and lens movements in rhesus monkeys of various ages. AU - Croft,Mary Ann, AU - McDonald,Jared P, AU - James,Rebecca J, AU - Heatley,Gregg A, AU - Lin,Ting-Li, AU - Lütjen-Drecoll,Elke, AU - Kaufman,Paul L, Y1 - 2008/06/14/ PY - 2008/6/17/pubmed PY - 2008/12/23/medline PY - 2008/6/17/entrez SP - 5484 EP - 94 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 49 IS - 12 N2 - PURPOSE: To determine how surgically altering the normal relationship between the lens and the ciliary body in rhesus monkeys affects centripetal ciliary body and lens movement. METHODS: In 18 rhesus monkey eyes (aged 6-27 years), accommodation was induced before and after surgery by electrical stimulation of the Edinger-Westphal nucleus. Accommodative amplitude was measured by coincidence refractometry. Goniovideography was performed before and after intra- and extracapsular lens extraction (ICLE, ECLE) and anterior regional zonulolysis (ARZ). Centripetal lens/capsule movements, centripetal ciliary process (CP) movements, and circumlental space were measured by computerized image analysis of the goniovideography images. RESULTS: Centripetal accommodative CP and capsule movement increased in velocity and amplitude after, compared with before, ECLE regardless of age (n = 5). The presence of the lens substance retarded capsule movement by approximately 21% in the young eyes and by approximately 62% in the older eyes. Post-ICLE compared with pre-ICLE centripetal accommodative CP movement was dampened in all eyes in which the anterior vitreous was disrupted (n = 7), but not in eyes in which the anterior vitreous was left intact (n = 2). After anterior regional zonulolysis (n = 4), lens position shifted toward the lysed quadrant during accommodation. CONCLUSIONS: The presence of the lens substance, capsule zonular attachments, and Wieger's ligament may play a role in centripetal CP movement. The capsule is still capable of centripetal movement in the older eye (although at a reduced capacity) and may have the ability to produce approximately 6 D of accommodation in the presence of a normal, young crystalline lens or a similar surrogate. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/18552393/Surgical_intervention_and_accommodative_responses,_I:_centripetal_ciliary_body,_capsule,_and_lens_movements_in_rhesus_monkeys_of_various_ages L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.08-1916 DB - PRIME DP - Unbound Medicine ER -