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Subthalamic stimulation for essential tremor. Short- and long-term results and critical target area.
Stereotact Funct Neurosurg. 2008; 86(4):253-8.SF

Abstract

BACKGROUND/AIMS/METHODS

In order to explore the usefulness and long-term result of subthalamic nucleus (STN) stimulation for the treatment of essential tremor (ET), we evaluated 3 groups of patients undergoing deep brain stimulation (DBS) for ET.

RESULTS

Group 1 consisted of 3 patients who 9 years ago at intra-operative testing had good tremor reduction from STN stimulation. The second group consisted of 10 patients treated with DBS in the ventral intermediate (Vim) nucleus of the thalamus. The third group comprised 9 patients subjected to STN stimulation for ET with 1-3 years of follow-up. The 3 ET patients with STN stimulation in group 1 have continued to have excellent tremor reduction for up to 9 years. The second group, with Vim stimulation, showed less favourable long-term results. All of the recent STN stimulation group experienced good tremor reduction, but some of the patients above 70 years of age reported troublesome side effects.

CONCLUSION

Provided that intra-operative test stimulation produces satisfactory tremor control, STN is a good target for long-term treatment of ET. For patients above the age of 70 years, however, the Vim is a preferable target.

Authors+Show Affiliations

Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden. goran.lind@karolinska.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18552522

Citation

Lind, Göran, et al. "Subthalamic Stimulation for Essential Tremor. Short- and Long-term Results and Critical Target Area." Stereotactic and Functional Neurosurgery, vol. 86, no. 4, 2008, pp. 253-8.
Lind G, Schechtmann G, Lind C, et al. Subthalamic stimulation for essential tremor. Short- and long-term results and critical target area. Stereotact Funct Neurosurg. 2008;86(4):253-8.
Lind, G., Schechtmann, G., Lind, C., Winter, J., Meyerson, B. A., & Linderoth, B. (2008). Subthalamic stimulation for essential tremor. Short- and long-term results and critical target area. Stereotactic and Functional Neurosurgery, 86(4), 253-8. https://doi.org/10.1159/000138769
Lind G, et al. Subthalamic Stimulation for Essential Tremor. Short- and Long-term Results and Critical Target Area. Stereotact Funct Neurosurg. 2008;86(4):253-8. PubMed PMID: 18552522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subthalamic stimulation for essential tremor. Short- and long-term results and critical target area. AU - Lind,Göran, AU - Schechtmann,Gaston, AU - Lind,Charlotta, AU - Winter,Jaleh, AU - Meyerson,Björn A, AU - Linderoth,Bengt, Y1 - 2008/06/13/ PY - 2008/6/17/pubmed PY - 2008/12/17/medline PY - 2008/6/17/entrez SP - 253 EP - 8 JF - Stereotactic and functional neurosurgery JO - Stereotact Funct Neurosurg VL - 86 IS - 4 N2 - BACKGROUND/AIMS/METHODS: In order to explore the usefulness and long-term result of subthalamic nucleus (STN) stimulation for the treatment of essential tremor (ET), we evaluated 3 groups of patients undergoing deep brain stimulation (DBS) for ET. RESULTS: Group 1 consisted of 3 patients who 9 years ago at intra-operative testing had good tremor reduction from STN stimulation. The second group consisted of 10 patients treated with DBS in the ventral intermediate (Vim) nucleus of the thalamus. The third group comprised 9 patients subjected to STN stimulation for ET with 1-3 years of follow-up. The 3 ET patients with STN stimulation in group 1 have continued to have excellent tremor reduction for up to 9 years. The second group, with Vim stimulation, showed less favourable long-term results. All of the recent STN stimulation group experienced good tremor reduction, but some of the patients above 70 years of age reported troublesome side effects. CONCLUSION: Provided that intra-operative test stimulation produces satisfactory tremor control, STN is a good target for long-term treatment of ET. For patients above the age of 70 years, however, the Vim is a preferable target. SN - 1423-0372 UR - https://www.unboundmedicine.com/medline/citation/18552522/Subthalamic_stimulation_for_essential_tremor__Short__and_long_term_results_and_critical_target_area_ L2 - https://www.karger.com?DOI=10.1159/000138769 DB - PRIME DP - Unbound Medicine ER -