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Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea.
J Nat Prod. 2008 Jul; 71(7):1173-7.JN

Abstract

Eight new sesquiterpenoids, named populene A-H (1-8), were isolated from dichloromethane extracts of the wood and dark heartwood of Thespesia populnea, together with 11 known compounds (9-19). Their structures were determined on the basis of spectroscopic analyses. The cytotoxic activity of isolated compounds was evaluated against four cancer cell lines: MCF-7, HeLa, HT-29, and KB. Mansonone E (11) and (+)-gossypol (18) showed significant activities. Their antibacterial properties against Bacillus subtilis, Staphylococcus aureus, and Enterococcus faecalis are also presented.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Boonsri S
Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
Karalai C
No affiliation info available
Ponglimanont C
No affiliation info available
Chantrapromma S
No affiliation info available
Kanjana-Opas A
No affiliation info available

MeSH

Anti-Bacterial AgentsAntineoplastic Agents, PhytogenicBacillus subtilisDrug Screening Assays, AntitumorEnterococcus faecalisGossypolHumansMalvaceaeMicrobial Sensitivity TestsMolecular StructureNaphthoquinonesNuclear Magnetic Resonance, BiomolecularPlants, MedicinalSesquiterpenesStaphylococcus aureusThailandWood

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18553924

Citation

Boonsri, Sompong, et al. "Cytotoxic and Antibacterial Sesquiterpenes From Thespesia Populnea." Journal of Natural Products, vol. 71, no. 7, 2008, pp. 1173-7.
Boonsri S, Karalai C, Ponglimanont C, et al. Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea. J Nat Prod. 2008;71(7):1173-7.
Boonsri, S., Karalai, C., Ponglimanont, C., Chantrapromma, S., & Kanjana-Opas, A. (2008). Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea. Journal of Natural Products, 71(7), 1173-7. https://doi.org/10.1021/np800055q
Boonsri S, et al. Cytotoxic and Antibacterial Sesquiterpenes From Thespesia Populnea. J Nat Prod. 2008;71(7):1173-7. PubMed PMID: 18553924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea. AU - Boonsri,Sompong, AU - Karalai,Chatchanok, AU - Ponglimanont,Chanita, AU - Chantrapromma,Suchada, AU - Kanjana-Opas,Akkharawit, Y1 - 2008/06/14/ PY - 2008/6/17/pubmed PY - 2008/9/30/medline PY - 2008/6/17/entrez SP - 1173 EP - 7 JF - Journal of natural products JO - J Nat Prod VL - 71 IS - 7 N2 - Eight new sesquiterpenoids, named populene A-H (1-8), were isolated from dichloromethane extracts of the wood and dark heartwood of Thespesia populnea, together with 11 known compounds (9-19). Their structures were determined on the basis of spectroscopic analyses. The cytotoxic activity of isolated compounds was evaluated against four cancer cell lines: MCF-7, HeLa, HT-29, and KB. Mansonone E (11) and (+)-gossypol (18) showed significant activities. Their antibacterial properties against Bacillus subtilis, Staphylococcus aureus, and Enterococcus faecalis are also presented. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/18553924/Cytotoxic_and_antibacterial_sesquiterpenes_from_Thespesia_populnea_ L2 - https://doi.org/10.1021/np800055q DB - PRIME DP - Unbound Medicine ER -