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Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis.
Fertil Steril. 2008 Dec; 90(6):2073-9.FS

Abstract

OBJECTIVE

To investigate the clinical value of differential white blood cell counts and neutrophil-to-lymphocyte ratio (NLR), by themselves or as adjunct to CA-125, in the diagnosis of endometriosis.

DESIGN

Retrospective study.

SETTING

University Medical Center.

PATIENT(S)

Two hundred thirty-one patients with endometriosis, 145 patients with benign ovarian tumors, and 384 healthy controls participated in this study.

INTERVENTION(S)

None.

MAIN OUTCOME MEASURE(S)

Sensitivities and specificities of differential white blood cell (WBC) counts, NLR, serum CA-125, and the combined marker (NLR and serum CA-125) were evaluated by receiver-operating characteristic (ROC) analysis.

RESULT(S)

The mean NLR and the combined marker in patients with endometriosis were significantly higher than those in patients without endometriosis. The NLR was able to discriminate patients with endometriosis from those with benign ovarian tumors and from healthy controls, and 25 of the 38 endometriosis patients (65.8%) with minimal-to-mild disease exceeded the cutoff value. The combined marker had a sensitivity of 69.3% and specificity of 83.9% with a cutoff value of 55.7, showing 13.5% increase in sensitivity but 8.9% decrease in specificity when compared with serum CA-125 at a cutoff level of 35 IU/mL. The elevated combined marker detected 16 patients with endometriosis (42.1%) with minimal-to-mild disease, whereas only 10 patients (26.3%) had their serum CA-125 levels at more than 35 IU/mL.

CONCLUSION(S)

Measurement of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Yongdong Severance Hospital, Yonsei University, College of Medicine, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18555226

Citation

Cho, SiHyun, et al. "Neutrophil-to-lymphocyte Ratio as an Adjunct to CA-125 for the Diagnosis of Endometriosis." Fertility and Sterility, vol. 90, no. 6, 2008, pp. 2073-9.
Cho S, Cho H, Nam A, et al. Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis. Fertil Steril. 2008;90(6):2073-9.
Cho, S., Cho, H., Nam, A., Kim, H. Y., Choi, Y. S., Park, K. H., Cho, D. J., & Lee, B. S. (2008). Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis. Fertility and Sterility, 90(6), 2073-9. https://doi.org/10.1016/j.fertnstert.2008.03.061
Cho S, et al. Neutrophil-to-lymphocyte Ratio as an Adjunct to CA-125 for the Diagnosis of Endometriosis. Fertil Steril. 2008;90(6):2073-9. PubMed PMID: 18555226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neutrophil-to-lymphocyte ratio as an adjunct to CA-125 for the diagnosis of endometriosis. AU - Cho,SiHyun, AU - Cho,Hanbyoul, AU - Nam,Anna, AU - Kim,Hye Yeon, AU - Choi,Young Sik, AU - Park,Ki Hyun, AU - Cho,Dong Je, AU - Lee,Byung Seok, Y1 - 2008/06/13/ PY - 2008/03/06/received PY - 2008/03/21/revised PY - 2008/03/25/accepted PY - 2008/6/17/pubmed PY - 2008/12/24/medline PY - 2008/6/17/entrez SP - 2073 EP - 9 JF - Fertility and sterility JO - Fertil Steril VL - 90 IS - 6 N2 - OBJECTIVE: To investigate the clinical value of differential white blood cell counts and neutrophil-to-lymphocyte ratio (NLR), by themselves or as adjunct to CA-125, in the diagnosis of endometriosis. DESIGN: Retrospective study. SETTING: University Medical Center. PATIENT(S): Two hundred thirty-one patients with endometriosis, 145 patients with benign ovarian tumors, and 384 healthy controls participated in this study. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Sensitivities and specificities of differential white blood cell (WBC) counts, NLR, serum CA-125, and the combined marker (NLR and serum CA-125) were evaluated by receiver-operating characteristic (ROC) analysis. RESULT(S): The mean NLR and the combined marker in patients with endometriosis were significantly higher than those in patients without endometriosis. The NLR was able to discriminate patients with endometriosis from those with benign ovarian tumors and from healthy controls, and 25 of the 38 endometriosis patients (65.8%) with minimal-to-mild disease exceeded the cutoff value. The combined marker had a sensitivity of 69.3% and specificity of 83.9% with a cutoff value of 55.7, showing 13.5% increase in sensitivity but 8.9% decrease in specificity when compared with serum CA-125 at a cutoff level of 35 IU/mL. The elevated combined marker detected 16 patients with endometriosis (42.1%) with minimal-to-mild disease, whereas only 10 patients (26.3%) had their serum CA-125 levels at more than 35 IU/mL. CONCLUSION(S): Measurement of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18555226/Neutrophil_to_lymphocyte_ratio_as_an_adjunct_to_CA_125_for_the_diagnosis_of_endometriosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)00735-8 DB - PRIME DP - Unbound Medicine ER -