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Comparison of maximal airway narrowing to methacholine between children and adults.
Eur Respir J. 1991 Apr; 4(4):421-8.ER

Abstract

Bronchial hyperresponsiveness in adults is characterized by an increased sensitivity as well as an elevated maximal response to inhaled bronchoconstrictors. In children, however, it is unknown whether the maximal response increases with increasing sensitivity. We investigated the maximal degree of airway narrowing to methacholine in nonasthmatic and asthmatic children (7-12 yrs), and compared it to that in adults. Nineteen children (9 normals, 10 asthmatics) and 19 adults (8 normals, 11 asthmatics) were selected in order to cover a wide distribution of bronchial responsiveness. All subjects underwent 2 methacholine challenge tests on separate days, by inhaling doubling doses using a standardized dosimeter technique (up to a noncumulative dose of 59 mumol). The response was measured by forced expiratory volume in one second (FEV1) and expressed as a percentage fall from baseline value. The complete dose-response curves were characterized by their position (PD20, the provocative dose causing a 20% fall in FEV1) and maximal response (MFEV1, the mean response on the plateau, defined as greater than or equal to 2 points within a 5% response range). Plateaus were observed in 13 children and 9 adults, the coefficient of repeatability of MFEV1 being 10.8 and 10.4% fall, respectively. There was an inverse relationship between log PD20 and MFEV1, which did not differ between children and adults (p greater than 0.15). In most of the asthmatic children and adults the plateau could not be measured (exceeding 50% fall in FEV1) if PD20 was less than 1 mumol. We conclude that, for a given bronchial sensitivity, the maximal response to inhaled methacholine is similar between children and adults.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Dept of Pulmonology, University Hospital Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1855570

Citation

de Pee, S, et al. "Comparison of Maximal Airway Narrowing to Methacholine Between Children and Adults." The European Respiratory Journal, vol. 4, no. 4, 1991, pp. 421-8.
de Pee S, Timmers MC, Hermans J, et al. Comparison of maximal airway narrowing to methacholine between children and adults. Eur Respir J. 1991;4(4):421-8.
de Pee, S., Timmers, M. C., Hermans, J., Duiverman, E. J., & Sterk, P. J. (1991). Comparison of maximal airway narrowing to methacholine between children and adults. The European Respiratory Journal, 4(4), 421-8.
de Pee S, et al. Comparison of Maximal Airway Narrowing to Methacholine Between Children and Adults. Eur Respir J. 1991;4(4):421-8. PubMed PMID: 1855570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of maximal airway narrowing to methacholine between children and adults. AU - de Pee,S, AU - Timmers,M C, AU - Hermans,J, AU - Duiverman,E J, AU - Sterk,P J, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 421 EP - 8 JF - The European respiratory journal JO - Eur. Respir. J. VL - 4 IS - 4 N2 - Bronchial hyperresponsiveness in adults is characterized by an increased sensitivity as well as an elevated maximal response to inhaled bronchoconstrictors. In children, however, it is unknown whether the maximal response increases with increasing sensitivity. We investigated the maximal degree of airway narrowing to methacholine in nonasthmatic and asthmatic children (7-12 yrs), and compared it to that in adults. Nineteen children (9 normals, 10 asthmatics) and 19 adults (8 normals, 11 asthmatics) were selected in order to cover a wide distribution of bronchial responsiveness. All subjects underwent 2 methacholine challenge tests on separate days, by inhaling doubling doses using a standardized dosimeter technique (up to a noncumulative dose of 59 mumol). The response was measured by forced expiratory volume in one second (FEV1) and expressed as a percentage fall from baseline value. The complete dose-response curves were characterized by their position (PD20, the provocative dose causing a 20% fall in FEV1) and maximal response (MFEV1, the mean response on the plateau, defined as greater than or equal to 2 points within a 5% response range). Plateaus were observed in 13 children and 9 adults, the coefficient of repeatability of MFEV1 being 10.8 and 10.4% fall, respectively. There was an inverse relationship between log PD20 and MFEV1, which did not differ between children and adults (p greater than 0.15). In most of the asthmatic children and adults the plateau could not be measured (exceeding 50% fall in FEV1) if PD20 was less than 1 mumol. We conclude that, for a given bronchial sensitivity, the maximal response to inhaled methacholine is similar between children and adults.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/1855570/Comparison_of_maximal_airway_narrowing_to_methacholine_between_children_and_adults_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -