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Interorgan synthesis of arginine is down-regulated in tumor-bearing mice undergoing surgical trauma.
Metabolism. 2008 Jul; 57(7):896-902.M

Abstract

Renal de novo arginine production has been suggested to be crucial for regulation of arginine production in disease. We investigated how the interorgan pathway for de novo arginine production is affected by the presence of malignant tumor and/or surgical trauma. Controls and methylcholanthrene-sarcoma-bearing mice were studied, both with and without undergoing laparotomy (n = 9-13 per group). One day after laparotomy, amino acid fluxes across the hindquarter, intestine, liver, and kidney were studied. In contrast to healthy mice, the liver of tumor-bearing mice took up citrulline (9 +/- 3 vs 1 +/- 2 nmol/[10 g min], P < .05), simultaneous with attenuated renal arginine output (4 +/- 3 vs 12 +/- 2 nmol/[10 g min], P < .05), despite increased intestinal conversion of glutamine to citrulline (15 +/- 3 vs 8 +/- 1 nmol/[10 g min], P < .05). In tumor-bearing mice undergoing surgery, intestinal citrulline output decreased (from 15 +/- 3 to 8 +/- 2 nmol/[10 g min], P < .05) and renal arginine output remained close to zero despite increased renal citrulline uptake (from 6 +/- 2 to 12 +/- 2 nmol/[10 g min], P < .05). In conclusion, the interorgan pathway for de novo arginine production was differently regulated depending on the pathophysiological situation. In methylcholanthrene-sarcoma-bearing mice, decreased de novo arginine production was accompanied by the presence of hepatic citrulline uptake, whereas tumor-bearing mice subjected to surgical trauma showed concomitant decreased intestinal citrulline output.

Authors+Show Affiliations

Department of Surgery, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18555829

Citation

Vissers, Yvonne L J., et al. "Interorgan Synthesis of Arginine Is Down-regulated in Tumor-bearing Mice Undergoing Surgical Trauma." Metabolism: Clinical and Experimental, vol. 57, no. 7, 2008, pp. 896-902.
Vissers YL, von Meyenfeldt MF, Luiking YC, et al. Interorgan synthesis of arginine is down-regulated in tumor-bearing mice undergoing surgical trauma. Metabolism. 2008;57(7):896-902.
Vissers, Y. L., von Meyenfeldt, M. F., Luiking, Y. C., Dejong, C. H., & Deutz, N. E. (2008). Interorgan synthesis of arginine is down-regulated in tumor-bearing mice undergoing surgical trauma. Metabolism: Clinical and Experimental, 57(7), 896-902. https://doi.org/10.1016/j.metabol.2008.02.003
Vissers YL, et al. Interorgan Synthesis of Arginine Is Down-regulated in Tumor-bearing Mice Undergoing Surgical Trauma. Metabolism. 2008;57(7):896-902. PubMed PMID: 18555829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interorgan synthesis of arginine is down-regulated in tumor-bearing mice undergoing surgical trauma. AU - Vissers,Yvonne L J, AU - von Meyenfeldt,Maarten F, AU - Luiking,Yvette C, AU - Dejong,Cornelis H C, AU - Deutz,Nicolaas E P, PY - 2006/08/21/received PY - 2008/02/14/accepted PY - 2008/6/17/pubmed PY - 2008/7/23/medline PY - 2008/6/17/entrez SP - 896 EP - 902 JF - Metabolism: clinical and experimental JO - Metabolism VL - 57 IS - 7 N2 - Renal de novo arginine production has been suggested to be crucial for regulation of arginine production in disease. We investigated how the interorgan pathway for de novo arginine production is affected by the presence of malignant tumor and/or surgical trauma. Controls and methylcholanthrene-sarcoma-bearing mice were studied, both with and without undergoing laparotomy (n = 9-13 per group). One day after laparotomy, amino acid fluxes across the hindquarter, intestine, liver, and kidney were studied. In contrast to healthy mice, the liver of tumor-bearing mice took up citrulline (9 +/- 3 vs 1 +/- 2 nmol/[10 g min], P < .05), simultaneous with attenuated renal arginine output (4 +/- 3 vs 12 +/- 2 nmol/[10 g min], P < .05), despite increased intestinal conversion of glutamine to citrulline (15 +/- 3 vs 8 +/- 1 nmol/[10 g min], P < .05). In tumor-bearing mice undergoing surgery, intestinal citrulline output decreased (from 15 +/- 3 to 8 +/- 2 nmol/[10 g min], P < .05) and renal arginine output remained close to zero despite increased renal citrulline uptake (from 6 +/- 2 to 12 +/- 2 nmol/[10 g min], P < .05). In conclusion, the interorgan pathway for de novo arginine production was differently regulated depending on the pathophysiological situation. In methylcholanthrene-sarcoma-bearing mice, decreased de novo arginine production was accompanied by the presence of hepatic citrulline uptake, whereas tumor-bearing mice subjected to surgical trauma showed concomitant decreased intestinal citrulline output. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/18555829/Interorgan_synthesis_of_arginine_is_down_regulated_in_tumor_bearing_mice_undergoing_surgical_trauma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(08)00074-7 DB - PRIME DP - Unbound Medicine ER -