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Bone mass and bone resorption in postmenopausal women with type 2 diabetes mellitus.
Metabolism. 2008 Jul; 57(7):940-5.M

Abstract

The aim of the present study was to examine the relationships between bone mass or bone resorption evaluated by urinary cross-linked N-telopeptides of type I collagen (NTx) concentration and known and potential contributors to bone mass or bone resorption such as sex hormones, age, duration of diabetes, glycemic control (hemoglobin A(1c) [HbA(1c)]), body mass index (BMI), severity of diabetic complications, smoking status, and current treatment of diabetes in postmenopausal women with type 2 diabetes mellitus (n = 196). In addition, the relationship of bone mass to pulse wave velocity, which is an earlier indicator of cardiovascular disease, was investigated in a subgroup of patients (n = 120). Bone mass was evaluated by the quantitative ultrasound method. A higher stiffness index indicates higher bone mass. Inverse correlations were found between the stiffness index and age (r = -0.374, P < .0001) and between the stiffness index and log (urinary albumin excretion) (r = -0.170, P = .0398), and a positive correlation was found between the stiffness index and serum dehydroepiandrosterone sulfate (DHEA-S) concentration (r = 0.201, P = .0136). No significant correlations were found between the stiffness index and duration of diabetes, HbA(1c), BMI, or serum estradiol concentration. No significant correlations were found between urinary NTx concentration and age, duration of diabetes, HbA(1c), BMI, serum estradiol concentration, or serum DHEA-S concentration. The stiffness index correlated inversely with urinary NTx concentration (r = -0.262, P = .0002). No significant correlation was found between the stiffness index and pulse wave velocity (r = -0.165, P = .0714). Multiple regression analysis demonstrated that serum DHEA-S concentration was an independent determinant of the stiffness index (beta = .207, P = .0428). In conclusion, serum DHEA-S concentration correlated positively with bone mass, whereas glycemic control, BMI, or duration of diabetes did not correlate with bone mass or urinary NTx concentration in postmenopausal women with type 2 diabetes mellitus.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18555835

Citation

Hosoda, Hiroko, et al. "Bone Mass and Bone Resorption in Postmenopausal Women With Type 2 Diabetes Mellitus." Metabolism: Clinical and Experimental, vol. 57, no. 7, 2008, pp. 940-5.
Hosoda H, Fukui M, Nakayama I, et al. Bone mass and bone resorption in postmenopausal women with type 2 diabetes mellitus. Metabolism. 2008;57(7):940-5.
Hosoda, H., Fukui, M., Nakayama, I., Asano, M., Kadono, M., Hasegawa, G., Yoshikawa, T., & Nakamura, N. (2008). Bone mass and bone resorption in postmenopausal women with type 2 diabetes mellitus. Metabolism: Clinical and Experimental, 57(7), 940-5. https://doi.org/10.1016/j.metabol.2008.02.009
Hosoda H, et al. Bone Mass and Bone Resorption in Postmenopausal Women With Type 2 Diabetes Mellitus. Metabolism. 2008;57(7):940-5. PubMed PMID: 18555835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mass and bone resorption in postmenopausal women with type 2 diabetes mellitus. AU - Hosoda,Hiroko, AU - Fukui,Michiaki, AU - Nakayama,Ichiko, AU - Asano,Mai, AU - Kadono,Mayuko, AU - Hasegawa,Goji, AU - Yoshikawa,Toshikazu, AU - Nakamura,Naoto, PY - 2007/07/17/received PY - 2008/02/12/accepted PY - 2008/6/17/pubmed PY - 2008/7/23/medline PY - 2008/6/17/entrez SP - 940 EP - 5 JF - Metabolism: clinical and experimental JO - Metabolism VL - 57 IS - 7 N2 - The aim of the present study was to examine the relationships between bone mass or bone resorption evaluated by urinary cross-linked N-telopeptides of type I collagen (NTx) concentration and known and potential contributors to bone mass or bone resorption such as sex hormones, age, duration of diabetes, glycemic control (hemoglobin A(1c) [HbA(1c)]), body mass index (BMI), severity of diabetic complications, smoking status, and current treatment of diabetes in postmenopausal women with type 2 diabetes mellitus (n = 196). In addition, the relationship of bone mass to pulse wave velocity, which is an earlier indicator of cardiovascular disease, was investigated in a subgroup of patients (n = 120). Bone mass was evaluated by the quantitative ultrasound method. A higher stiffness index indicates higher bone mass. Inverse correlations were found between the stiffness index and age (r = -0.374, P < .0001) and between the stiffness index and log (urinary albumin excretion) (r = -0.170, P = .0398), and a positive correlation was found between the stiffness index and serum dehydroepiandrosterone sulfate (DHEA-S) concentration (r = 0.201, P = .0136). No significant correlations were found between the stiffness index and duration of diabetes, HbA(1c), BMI, or serum estradiol concentration. No significant correlations were found between urinary NTx concentration and age, duration of diabetes, HbA(1c), BMI, serum estradiol concentration, or serum DHEA-S concentration. The stiffness index correlated inversely with urinary NTx concentration (r = -0.262, P = .0002). No significant correlation was found between the stiffness index and pulse wave velocity (r = -0.165, P = .0714). Multiple regression analysis demonstrated that serum DHEA-S concentration was an independent determinant of the stiffness index (beta = .207, P = .0428). In conclusion, serum DHEA-S concentration correlated positively with bone mass, whereas glycemic control, BMI, or duration of diabetes did not correlate with bone mass or urinary NTx concentration in postmenopausal women with type 2 diabetes mellitus. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/18555835/Bone_mass_and_bone_resorption_in_postmenopausal_women_with_type_2_diabetes_mellitus_ L2 - https://www.clinicalkey.com/content/playBy/pii?v=S0026-0495(08)00080-2 DB - PRIME DP - Unbound Medicine ER -