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Low birth weight and later development of insulin resistance and biochemical/clinical features of polycystic ovary syndrome.
Metabolism. 2008 Jul; 57(7):999-1004.M

Abstract

Reduced insulin sensitivity in adult life has been reported in subjects born at term small for gestational age (SGA) and in those born prematurely with very low birth weight (LBW) (<1,500 g). We assessed whether LBW (<2,500 g) young women, irrespective of whether they were born SGA or adequate for gestational age (premature AGA), exhibited a reduction in insulin sensitivity through a prospective historical design. The risk of developing biochemical and clinical features of polycystic ovary syndrome was also investigated. The study population included 35 LBW women (19 SGA [BW range, 1,000-2,400 g] and 16 premature AGA [BW range, 1,700-2,440 g]) aged 21.8 +/- 1.8 years and 35 term AGA controls, of similar age, recruited from a neonatal registry. All women underwent clinical, ultrasonographic, hormonal, and metabolic evaluations, including the composite insulin sensitivity index. Women under hormonal contraception (21.4%) were excluded from hormonal and metabolic analyses. Composite insulin sensitivity index was significantly lower in LBW women even when the 2 LBW subgroups, SGA and premature AGA, were analyzed separately (4.4 +/- 2.2 and 4.0 +/- 1.7, respectively) than in controls (6.9 +/- 4.4). The LBW women showed a significantly higher incidence proportion of irregular menses (14/35 [40%] vs 2/35 [5.7%]) and a significantly higher free androgen index (5.8 +/- 3.5 vs 3.9 +/- 3.2). They also showed a nonsignificantly higher proportion of hirsutism, acne, and polycystic ovaries. In conclusion, LBW (<2,500 g) young women, irrespective of whether they were SGA and premature AGA, exhibited a reduction in insulin sensitivity as compared with born at term AGA women. Furthermore, they exhibited an increased risk of developing clinical and biochemical features of polycystic ovary syndrome.

Authors+Show Affiliations

Department of Internal Medicine and Public Health, University of L'Aquila, 67100 Coppito, L'Aquila, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18555843

Citation

Pandolfi, Caterina, et al. "Low Birth Weight and Later Development of Insulin Resistance and Biochemical/clinical Features of Polycystic Ovary Syndrome." Metabolism: Clinical and Experimental, vol. 57, no. 7, 2008, pp. 999-1004.
Pandolfi C, Zugaro A, Lattanzio F, et al. Low birth weight and later development of insulin resistance and biochemical/clinical features of polycystic ovary syndrome. Metabolism. 2008;57(7):999-1004.
Pandolfi, C., Zugaro, A., Lattanzio, F., Necozione, S., Barbonetti, A., Colangeli, M. S., Francavilla, S., & Francavilla, F. (2008). Low birth weight and later development of insulin resistance and biochemical/clinical features of polycystic ovary syndrome. Metabolism: Clinical and Experimental, 57(7), 999-1004. https://doi.org/10.1016/j.metabol.2008.02.018
Pandolfi C, et al. Low Birth Weight and Later Development of Insulin Resistance and Biochemical/clinical Features of Polycystic Ovary Syndrome. Metabolism. 2008;57(7):999-1004. PubMed PMID: 18555843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low birth weight and later development of insulin resistance and biochemical/clinical features of polycystic ovary syndrome. AU - Pandolfi,Caterina, AU - Zugaro,Antonella, AU - Lattanzio,Francesca, AU - Necozione,Stefano, AU - Barbonetti,Arcangelo, AU - Colangeli,Maria Simonetta, AU - Francavilla,Sandro, AU - Francavilla,Felice, PY - 2007/10/18/received PY - 2008/02/11/accepted PY - 2008/6/17/pubmed PY - 2008/7/23/medline PY - 2008/6/17/entrez SP - 999 EP - 1004 JF - Metabolism: clinical and experimental JO - Metabolism VL - 57 IS - 7 N2 - Reduced insulin sensitivity in adult life has been reported in subjects born at term small for gestational age (SGA) and in those born prematurely with very low birth weight (LBW) (<1,500 g). We assessed whether LBW (<2,500 g) young women, irrespective of whether they were born SGA or adequate for gestational age (premature AGA), exhibited a reduction in insulin sensitivity through a prospective historical design. The risk of developing biochemical and clinical features of polycystic ovary syndrome was also investigated. The study population included 35 LBW women (19 SGA [BW range, 1,000-2,400 g] and 16 premature AGA [BW range, 1,700-2,440 g]) aged 21.8 +/- 1.8 years and 35 term AGA controls, of similar age, recruited from a neonatal registry. All women underwent clinical, ultrasonographic, hormonal, and metabolic evaluations, including the composite insulin sensitivity index. Women under hormonal contraception (21.4%) were excluded from hormonal and metabolic analyses. Composite insulin sensitivity index was significantly lower in LBW women even when the 2 LBW subgroups, SGA and premature AGA, were analyzed separately (4.4 +/- 2.2 and 4.0 +/- 1.7, respectively) than in controls (6.9 +/- 4.4). The LBW women showed a significantly higher incidence proportion of irregular menses (14/35 [40%] vs 2/35 [5.7%]) and a significantly higher free androgen index (5.8 +/- 3.5 vs 3.9 +/- 3.2). They also showed a nonsignificantly higher proportion of hirsutism, acne, and polycystic ovaries. In conclusion, LBW (<2,500 g) young women, irrespective of whether they were SGA and premature AGA, exhibited a reduction in insulin sensitivity as compared with born at term AGA women. Furthermore, they exhibited an increased risk of developing clinical and biochemical features of polycystic ovary syndrome. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/18555843/Low_birth_weight_and_later_development_of_insulin_resistance_and_biochemical/clinical_features_of_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(08)00089-9 DB - PRIME DP - Unbound Medicine ER -