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Motor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats.
Exp Neurol. 2008 Aug; 212(2):562-5.EN

Abstract

In the present study, we compared the effects of implanting peripheral sensory nerve and motor nerve on motoneuron survival and regeneration after spinal root avulsion in adult rats. Our results showed that 116% more motoneurons regenerated axons into the motor than the sensory nerve graft and 59% of motoneurons survived in the motor nerve-implanted group compared to 48% in the sensory nerve-implanted group. We demonstrated by real time PCR that levels of BDNF and GDNF mRNA were significantly higher in the motor than the sensory nerve five days after implantation into the spinal cord. This may account for the superiority of motor over sensory nerve in promoting motor axon regeneration and motoneuron survival. Lastly, we also showed that implanting two sensory nerves enhances motoneuron regeneration over implanting a single nerve.

Authors+Show Affiliations

Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18555993

Citation

Chu, Tak-Ho, et al. "Motor Nerve Graft Is Better Than Sensory Nerve Graft for Survival and Regeneration of Motoneurons After Spinal Root Avulsion in Adult Rats." Experimental Neurology, vol. 212, no. 2, 2008, pp. 562-5.
Chu TH, Du Y, Wu W. Motor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats. Exp Neurol. 2008;212(2):562-5.
Chu, T. H., Du, Y., & Wu, W. (2008). Motor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats. Experimental Neurology, 212(2), 562-5. https://doi.org/10.1016/j.expneurol.2008.05.001
Chu TH, Du Y, Wu W. Motor Nerve Graft Is Better Than Sensory Nerve Graft for Survival and Regeneration of Motoneurons After Spinal Root Avulsion in Adult Rats. Exp Neurol. 2008;212(2):562-5. PubMed PMID: 18555993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor nerve graft is better than sensory nerve graft for survival and regeneration of motoneurons after spinal root avulsion in adult rats. AU - Chu,Tak-Ho, AU - Du,Yang, AU - Wu,Wutian, Y1 - 2008/05/11/ PY - 2008/01/09/received PY - 2008/04/14/revised PY - 2008/05/05/accepted PY - 2008/6/17/pubmed PY - 2008/9/3/medline PY - 2008/6/17/entrez SP - 562 EP - 5 JF - Experimental neurology JO - Exp. Neurol. VL - 212 IS - 2 N2 - In the present study, we compared the effects of implanting peripheral sensory nerve and motor nerve on motoneuron survival and regeneration after spinal root avulsion in adult rats. Our results showed that 116% more motoneurons regenerated axons into the motor than the sensory nerve graft and 59% of motoneurons survived in the motor nerve-implanted group compared to 48% in the sensory nerve-implanted group. We demonstrated by real time PCR that levels of BDNF and GDNF mRNA were significantly higher in the motor than the sensory nerve five days after implantation into the spinal cord. This may account for the superiority of motor over sensory nerve in promoting motor axon regeneration and motoneuron survival. Lastly, we also showed that implanting two sensory nerves enhances motoneuron regeneration over implanting a single nerve. SN - 1090-2430 UR - https://www.unboundmedicine.com/medline/citation/18555993/Motor_nerve_graft_is_better_than_sensory_nerve_graft_for_survival_and_regeneration_of_motoneurons_after_spinal_root_avulsion_in_adult_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(08)00216-1 DB - PRIME DP - Unbound Medicine ER -