Tags

Type your tag names separated by a space and hit enter

Evaluation of the potential in vivo genotoxicity of quercetin.
Mutat Res. 2008 Jun 30; 654(1):38-44.MR

Abstract

Quercetin, a naturally occurring flavonol commonly detected in apples, cranberries, blueberries, and onions, has been reported to possess antioxidant, anti-carcinogenic, anti-inflammatory, and cardioprotective properties. While positive results have been consistently reported in numerous in vitro mutagenicity and genotoxicity assays of quercetin, tested in vivo, quercetin has generally produced negative results in such studies. Furthermore, no evidence of carcinogenicity related to the oral administration of quercetin was observed in chronic rodent assays. In order to further define the in vivo genotoxic potential of quercetin, a bone marrow micronucleus assay and an unscheduled DNA synthesis (UDS) assay were conducted in Wistar rats. Administered orally to male rats at dose levels of up to 2000 mg/kg body weight, quercetin did not increase the number of micronucleated polychromatic erythrocytes (MN-PCE) 24 or 48 h following dosing in the micronucleus assay. Likewise, orally administered quercetin (up to 2000 mg/kg body weight) did not induce UDS in hepatocytes of male or female rats. While measurable levels of metabolized quercetin were observed in rat plasma samples for up to 48 h after dosing, peaking at 1h following treatment administration, the unmetabolized aglycone was not identified in either plasma or bone marrow. With the exception of only a few rats, the aglycone was also not detected in liver tissue. These results demonstrate that quercetin is not genotoxic under the conditions of these assays and further support the negative results of previously conducted in vivo assays.

Authors+Show Affiliations

Merck KGaA, Frankfurter Str. 250, 64293 Darmstadt, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18556240

Citation

Utesch, D, et al. "Evaluation of the Potential in Vivo Genotoxicity of Quercetin." Mutation Research, vol. 654, no. 1, 2008, pp. 38-44.
Utesch D, Feige K, Dasenbrock J, et al. Evaluation of the potential in vivo genotoxicity of quercetin. Mutat Res. 2008;654(1):38-44.
Utesch, D., Feige, K., Dasenbrock, J., Broschard, T. H., Harwood, M., Danielewska-Nikiel, B., & Lines, T. C. (2008). Evaluation of the potential in vivo genotoxicity of quercetin. Mutation Research, 654(1), 38-44. https://doi.org/10.1016/j.mrgentox.2008.04.008
Utesch D, et al. Evaluation of the Potential in Vivo Genotoxicity of Quercetin. Mutat Res. 2008 Jun 30;654(1):38-44. PubMed PMID: 18556240.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the potential in vivo genotoxicity of quercetin. AU - Utesch,D, AU - Feige,K, AU - Dasenbrock,J, AU - Broschard,T H, AU - Harwood,M, AU - Danielewska-Nikiel,B, AU - Lines,T C, Y1 - 2008/05/02/ PY - 2008/01/08/received PY - 2008/04/18/revised PY - 2008/04/22/accepted PY - 2008/6/17/pubmed PY - 2008/9/16/medline PY - 2008/6/17/entrez SP - 38 EP - 44 JF - Mutation research JO - Mutat Res VL - 654 IS - 1 N2 - Quercetin, a naturally occurring flavonol commonly detected in apples, cranberries, blueberries, and onions, has been reported to possess antioxidant, anti-carcinogenic, anti-inflammatory, and cardioprotective properties. While positive results have been consistently reported in numerous in vitro mutagenicity and genotoxicity assays of quercetin, tested in vivo, quercetin has generally produced negative results in such studies. Furthermore, no evidence of carcinogenicity related to the oral administration of quercetin was observed in chronic rodent assays. In order to further define the in vivo genotoxic potential of quercetin, a bone marrow micronucleus assay and an unscheduled DNA synthesis (UDS) assay were conducted in Wistar rats. Administered orally to male rats at dose levels of up to 2000 mg/kg body weight, quercetin did not increase the number of micronucleated polychromatic erythrocytes (MN-PCE) 24 or 48 h following dosing in the micronucleus assay. Likewise, orally administered quercetin (up to 2000 mg/kg body weight) did not induce UDS in hepatocytes of male or female rats. While measurable levels of metabolized quercetin were observed in rat plasma samples for up to 48 h after dosing, peaking at 1h following treatment administration, the unmetabolized aglycone was not identified in either plasma or bone marrow. With the exception of only a few rats, the aglycone was also not detected in liver tissue. These results demonstrate that quercetin is not genotoxic under the conditions of these assays and further support the negative results of previously conducted in vivo assays. SN - 0027-5107 UR - https://www.unboundmedicine.com/medline/citation/18556240/Evaluation_of_the_potential_in_vivo_genotoxicity_of_quercetin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1383-5718(08)00130-7 DB - PRIME DP - Unbound Medicine ER -