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Late cardiovascular events after allogeneic hematopoietic stem cell transplantation: a retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation.
Haematologica. 2008 Aug; 93(8):1203-10.H

Abstract

BACKGROUND

Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors.

DESIGN AND METHODS

This is a retrospective multicenter European Group of Blood and Marrow Transplantation (EBMT) analysis, including 548 long-term survivors treated in ten EBMT transplant centers, who underwent hematopoietic stem cell transplantation between 1990 and 1995 and survived >or=1 year after the transplant. All arterial events occurring after hematopoietic stem cell transplantation (cerebral, coronary, peripheral) were reported.

RESULTS

Twenty (3.6%) out of 548 patients had a cardiovascular event in at least one arterial territory. The median age at occurrence of cardiovascular events was 54 years (range, 41-70). The cumulative incidence of a first arterial event 15 years after hematopoietic stem cell transplantation was 6% (95% CI, 3%-10%). The cumulative incidence for patients with a high global cardiovascular risk score, defined as having >or=50% of the risk factors (arterial hypertension, diabetes, dys-lipidemia, increased body-mass index, physical inactivity, smoking) was 17%, as compared to 4% in those with a low risk score. In multivariate analysis age older than 30 years at last follow-up, and a high global cardiovascular risk score were associated with, respectively, 6.4-fold and 9.8-fold increases in the risk of an arterial event.

CONCLUSIONS

Long-term survivors after allogeneic hematopoietic stem cell transplantation are likely to have an increased risk of premature cardiovascular accidents.

Authors+Show Affiliations

Department of Hematology, University Hospital, CH 4031-Basel, Switzerland. tichelli@datacomm.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

18556401

Citation

Tichelli, André, et al. "Late Cardiovascular Events After Allogeneic Hematopoietic Stem Cell Transplantation: a Retrospective Multicenter Study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation." Haematologica, vol. 93, no. 8, 2008, pp. 1203-10.
Tichelli A, Passweg J, Wójcik D, et al. Late cardiovascular events after allogeneic hematopoietic stem cell transplantation: a retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation. Haematologica. 2008;93(8):1203-10.
Tichelli, A., Passweg, J., Wójcik, D., Rovó, A., Harousseau, J. L., Masszi, T., Zander, A., Békássy, A., Crawley, C., Arat, M., Sica, S., Lutz, P., & Socié, G. (2008). Late cardiovascular events after allogeneic hematopoietic stem cell transplantation: a retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation. Haematologica, 93(8), 1203-10. https://doi.org/10.3324/haematol.12949
Tichelli A, et al. Late Cardiovascular Events After Allogeneic Hematopoietic Stem Cell Transplantation: a Retrospective Multicenter Study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation. Haematologica. 2008;93(8):1203-10. PubMed PMID: 18556401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Late cardiovascular events after allogeneic hematopoietic stem cell transplantation: a retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation. AU - Tichelli,André, AU - Passweg,Jakob, AU - Wójcik,Dorota, AU - Rovó,Alicia, AU - Harousseau,Jean-Luc, AU - Masszi,Tamas, AU - Zander,Axel, AU - Békássy,Albert, AU - Crawley,Charles, AU - Arat,Mutlu, AU - Sica,Simona, AU - Lutz,Patrick, AU - Socié,Gérard, AU - ,, Y1 - 2008/06/12/ PY - 2008/6/17/pubmed PY - 2008/10/10/medline PY - 2008/6/17/entrez SP - 1203 EP - 10 JF - Haematologica JO - Haematologica VL - 93 IS - 8 N2 - BACKGROUND: Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. DESIGN AND METHODS: This is a retrospective multicenter European Group of Blood and Marrow Transplantation (EBMT) analysis, including 548 long-term survivors treated in ten EBMT transplant centers, who underwent hematopoietic stem cell transplantation between 1990 and 1995 and survived >or=1 year after the transplant. All arterial events occurring after hematopoietic stem cell transplantation (cerebral, coronary, peripheral) were reported. RESULTS: Twenty (3.6%) out of 548 patients had a cardiovascular event in at least one arterial territory. The median age at occurrence of cardiovascular events was 54 years (range, 41-70). The cumulative incidence of a first arterial event 15 years after hematopoietic stem cell transplantation was 6% (95% CI, 3%-10%). The cumulative incidence for patients with a high global cardiovascular risk score, defined as having >or=50% of the risk factors (arterial hypertension, diabetes, dys-lipidemia, increased body-mass index, physical inactivity, smoking) was 17%, as compared to 4% in those with a low risk score. In multivariate analysis age older than 30 years at last follow-up, and a high global cardiovascular risk score were associated with, respectively, 6.4-fold and 9.8-fold increases in the risk of an arterial event. CONCLUSIONS: Long-term survivors after allogeneic hematopoietic stem cell transplantation are likely to have an increased risk of premature cardiovascular accidents. SN - 1592-8721 UR - https://www.unboundmedicine.com/medline/citation/18556401/Late_cardiovascular_events_after_allogeneic_hematopoietic_stem_cell_transplantation:_a_retrospective_multicenter_study_of_the_Late_Effects_Working_Party_of_the_European_Group_for_Blood_and_Marrow_Transplantation_ L2 - https://doi.org/10.3324/haematol.12949 DB - PRIME DP - Unbound Medicine ER -