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Stripping voltammetric determination of valsartan in bulk and pharmaceutical products.
Pharmazie. 2008 May; 63(5):337-41.P

Abstract

Stripping voltammetric determination of valsartan using a hanging mercury drop electrode (HMDE) was described. The method was based on adsorptive accumulation of the species at HMDE, followed by first harmonic alternating current AC stripping sweep at pH 6. The behavior of adsorptive stripping response was thoroughly studied under various experimental conditions, e.g. type of supporting electrolyte, pH, accumulation time, scan rate and mode of sweep. In Britton-Robinson buffer solution, a quasi-reversible reduction process involving transfer two electrons and two protons was took place. The response was linear over the concentration range of 0.08-0.64 microg/ml with regression coefficient 0.999 and limit of detection 0.02 microg/ml. The average of determinations of the cited compound in oral dosages with its standard deviation was 101.11 +/- 4.38%. The result obtained by the proposed method was compared with that obtained by the UV-spectrophotometric technique. Furthermore, the proposed method was successfully applied as stability-indicating method for determining valsartan in the presence of its acid induced degradation products.

Authors+Show Affiliations

Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo, Egypt. ihihabib@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18557415

Citation

Habib, I H I., et al. "Stripping Voltammetric Determination of Valsartan in Bulk and Pharmaceutical Products." Die Pharmazie, vol. 63, no. 5, 2008, pp. 337-41.
Habib IH, Weshahy SA, Toubar SS, et al. Stripping voltammetric determination of valsartan in bulk and pharmaceutical products. Pharmazie. 2008;63(5):337-41.
Habib, I. H., Weshahy, S. A., Toubar, S. S., & el-Alamin, M. M. (2008). Stripping voltammetric determination of valsartan in bulk and pharmaceutical products. Die Pharmazie, 63(5), 337-41.
Habib IH, et al. Stripping Voltammetric Determination of Valsartan in Bulk and Pharmaceutical Products. Pharmazie. 2008;63(5):337-41. PubMed PMID: 18557415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stripping voltammetric determination of valsartan in bulk and pharmaceutical products. AU - Habib,I H I, AU - Weshahy,S A, AU - Toubar,S S, AU - el-Alamin,M M A, PY - 2008/6/19/pubmed PY - 2008/7/23/medline PY - 2008/6/19/entrez SP - 337 EP - 41 JF - Die Pharmazie JO - Pharmazie VL - 63 IS - 5 N2 - Stripping voltammetric determination of valsartan using a hanging mercury drop electrode (HMDE) was described. The method was based on adsorptive accumulation of the species at HMDE, followed by first harmonic alternating current AC stripping sweep at pH 6. The behavior of adsorptive stripping response was thoroughly studied under various experimental conditions, e.g. type of supporting electrolyte, pH, accumulation time, scan rate and mode of sweep. In Britton-Robinson buffer solution, a quasi-reversible reduction process involving transfer two electrons and two protons was took place. The response was linear over the concentration range of 0.08-0.64 microg/ml with regression coefficient 0.999 and limit of detection 0.02 microg/ml. The average of determinations of the cited compound in oral dosages with its standard deviation was 101.11 +/- 4.38%. The result obtained by the proposed method was compared with that obtained by the UV-spectrophotometric technique. Furthermore, the proposed method was successfully applied as stability-indicating method for determining valsartan in the presence of its acid induced degradation products. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/18557415/Stripping_voltammetric_determination_of_valsartan_in_bulk_and_pharmaceutical_products_ DB - PRIME DP - Unbound Medicine ER -