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Hepatitis E virus-related cirrhosis in kidney- and kidney-pancreas-transplant recipients.
Am J Transplant. 2008 Aug; 8(8):1744-8.AJ

Abstract

Hepatitis E virus (HEV) infection was thought to be responsible for acute hepatitis that did not become chronic. However, we have recently reported that HEV infection can evolve to chronic hepatitis, at least in solid-organ transplant patients. We report on two cases of rapidly progressive of HEV-related cirrhosis that occurred in two organ-transplant patients. Case 1: A kidney-pancreas-transplant patient developed acute HEV hepatitis 60 months after transplantation, which evolved to chronicity as defined by persisting elevated liver-enzyme levels and positive serum HEV RNA. At 22 months after the acute phase, she presented with cirrhosis and portal hypertension, that is ascites and esophagus varices. Case 2: A kidney-transplant patient developed acute hepatitis 36 months after transplantation, which persisted and remained unexplained for 38 months. Then, HEV RNA was searched for in their serum and stools, and was found to be positive in both. Retrospective analysis of available stored serum, mainly the serum obtained at the acute phase, confirmed the diagnosis of chronic hepatitis E. In both cases, a liver biopsy showed cirrhosis. We conclude that HEV infection cannot only evolve to chronic hepatitis, but can also be responsible for rapidly progressing cirrhosis in organ-transplant patients.

Authors+Show Affiliations

Department of Nephrology, Dialysis and Multi-Organ Transplantation, and INSERM U858, IFR 31, CHU Rangueil, Toulouse, France. kamar.n@chu-toulouse.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18557740

Citation

Kamar, N, et al. "Hepatitis E Virus-related Cirrhosis in Kidney- and Kidney-pancreas-transplant Recipients." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 8, no. 8, 2008, pp. 1744-8.
Kamar N, Mansuy JM, Cointault O, et al. Hepatitis E virus-related cirrhosis in kidney- and kidney-pancreas-transplant recipients. Am J Transplant. 2008;8(8):1744-8.
Kamar, N., Mansuy, J. M., Cointault, O., Selves, J., Abravanel, F., Danjoux, M., Otal, P., Esposito, L., Durand, D., Izopet, J., & Rostaing, L. (2008). Hepatitis E virus-related cirrhosis in kidney- and kidney-pancreas-transplant recipients. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 8(8), 1744-8. https://doi.org/10.1111/j.1600-6143.2008.02286.x
Kamar N, et al. Hepatitis E Virus-related Cirrhosis in Kidney- and Kidney-pancreas-transplant Recipients. Am J Transplant. 2008;8(8):1744-8. PubMed PMID: 18557740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis E virus-related cirrhosis in kidney- and kidney-pancreas-transplant recipients. AU - Kamar,N, AU - Mansuy,J-M, AU - Cointault,O, AU - Selves,J, AU - Abravanel,F, AU - Danjoux,M, AU - Otal,P, AU - Esposito,L, AU - Durand,D, AU - Izopet,J, AU - Rostaing,L, Y1 - 2008/06/28/ PY - 2008/6/19/pubmed PY - 2009/1/1/medline PY - 2008/6/19/entrez SP - 1744 EP - 8 JF - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JO - Am J Transplant VL - 8 IS - 8 N2 - Hepatitis E virus (HEV) infection was thought to be responsible for acute hepatitis that did not become chronic. However, we have recently reported that HEV infection can evolve to chronic hepatitis, at least in solid-organ transplant patients. We report on two cases of rapidly progressive of HEV-related cirrhosis that occurred in two organ-transplant patients. Case 1: A kidney-pancreas-transplant patient developed acute HEV hepatitis 60 months after transplantation, which evolved to chronicity as defined by persisting elevated liver-enzyme levels and positive serum HEV RNA. At 22 months after the acute phase, she presented with cirrhosis and portal hypertension, that is ascites and esophagus varices. Case 2: A kidney-transplant patient developed acute hepatitis 36 months after transplantation, which persisted and remained unexplained for 38 months. Then, HEV RNA was searched for in their serum and stools, and was found to be positive in both. Retrospective analysis of available stored serum, mainly the serum obtained at the acute phase, confirmed the diagnosis of chronic hepatitis E. In both cases, a liver biopsy showed cirrhosis. We conclude that HEV infection cannot only evolve to chronic hepatitis, but can also be responsible for rapidly progressing cirrhosis in organ-transplant patients. SN - 1600-6143 UR - https://www.unboundmedicine.com/medline/citation/18557740/Hepatitis_E_virus_related_cirrhosis_in_kidney__and_kidney_pancreas_transplant_recipients_ L2 - https://doi.org/10.1111/j.1600-6143.2008.02286.x DB - PRIME DP - Unbound Medicine ER -