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Airway epithelial cell senescence in the lung allograft.
Am J Transplant. 2008 Jul; 8(7):1544-9.AJ

Abstract

Chronic lung allograft dysfunction, manifesting as bronchiolitis obliterans syndrome (BOS), is characterized by airway epithelial injury, impaired epithelial regeneration and subsequent airway remodeling. Increased cellular senescence has been reported in renal and liver allografts affected by chronic allograft dysfunction but the significance of cellular senescence in the airway epithelium of the transplanted lung is unknown. Thirty-four lung transplant recipients, 20 with stable graft function and 14 with BOS, underwent transbronchial lung biopsy and histochemical studies for senescence markers in small airways. Compared to nontransplant control lung tissue (n = 9), lung allografts demonstrate significantly increased airway epithelial staining for senescence-associated beta galactosidase (SA beta-gal) (p = 0.0215), p16(ink4a) (p = 0.0002) and p21(waf1/cip) (p = 0.0138) but there was no difference in expression of these markers between stable and BOS affected recipients (p > 0.05). This preliminary cross-sectional study demonstrates that cellular senescence occurs with increased frequency in the airway epithelium of the lung allograft but does not establish any association between airway epithelial senescence and BOS. A prospective longitudinal study is required to better address any potential causal association between airway epithelial senescence in stable allograft recipients and the subsequent development of BOS.

Authors+Show Affiliations

Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Newcastle University, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18557742

Citation

Parker, S M., et al. "Airway Epithelial Cell Senescence in the Lung Allograft." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 8, no. 7, 2008, pp. 1544-9.
Parker SM, Goriwiec MR, Borthwick LA, et al. Airway epithelial cell senescence in the lung allograft. Am J Transplant. 2008;8(7):1544-9.
Parker, S. M., Goriwiec, M. R., Borthwick, L. A., Johnson, G., Ward, C., Lordan, J. L., Corris, P. A., Saretzki, G. C., & Fisher, A. J. (2008). Airway epithelial cell senescence in the lung allograft. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 8(7), 1544-9. https://doi.org/10.1111/j.1600-6143.2008.02284.x
Parker SM, et al. Airway Epithelial Cell Senescence in the Lung Allograft. Am J Transplant. 2008;8(7):1544-9. PubMed PMID: 18557742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airway epithelial cell senescence in the lung allograft. AU - Parker,S M, AU - Goriwiec,M R, AU - Borthwick,L A, AU - Johnson,G, AU - Ward,C, AU - Lordan,J L, AU - Corris,P A, AU - Saretzki,G C, AU - Fisher,A J, PY - 2008/6/19/pubmed PY - 2008/8/30/medline PY - 2008/6/19/entrez SP - 1544 EP - 9 JF - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JO - Am. J. Transplant. VL - 8 IS - 7 N2 - Chronic lung allograft dysfunction, manifesting as bronchiolitis obliterans syndrome (BOS), is characterized by airway epithelial injury, impaired epithelial regeneration and subsequent airway remodeling. Increased cellular senescence has been reported in renal and liver allografts affected by chronic allograft dysfunction but the significance of cellular senescence in the airway epithelium of the transplanted lung is unknown. Thirty-four lung transplant recipients, 20 with stable graft function and 14 with BOS, underwent transbronchial lung biopsy and histochemical studies for senescence markers in small airways. Compared to nontransplant control lung tissue (n = 9), lung allografts demonstrate significantly increased airway epithelial staining for senescence-associated beta galactosidase (SA beta-gal) (p = 0.0215), p16(ink4a) (p = 0.0002) and p21(waf1/cip) (p = 0.0138) but there was no difference in expression of these markers between stable and BOS affected recipients (p > 0.05). This preliminary cross-sectional study demonstrates that cellular senescence occurs with increased frequency in the airway epithelium of the lung allograft but does not establish any association between airway epithelial senescence and BOS. A prospective longitudinal study is required to better address any potential causal association between airway epithelial senescence in stable allograft recipients and the subsequent development of BOS. SN - 1600-6143 UR - https://www.unboundmedicine.com/medline/citation/18557742/Airway_epithelial_cell_senescence_in_the_lung_allograft_ L2 - https://doi.org/10.1111/j.1600-6143.2008.02284.x DB - PRIME DP - Unbound Medicine ER -