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The optimum bolus dose of remifentanil to facilitate laryngeal mask airway insertion with a single standard dose of propofol at induction in children.
Anaesthesia. 2008 Sep; 63(9):954-8.A

Abstract

The purpose of this study was to determine the optimal bolus dose of remifentanil required for the successful insertion of the laryngeal mask airway during propofol induction in children without a neuromuscular blocking agent. Twenty-six paediatric patients, aged 3-10 years, requiring anaesthesia for short ambulatory surgery were recruited. A predetermined bolus dose of remifentanil was injected over 30 s, followed by propofol 2.5 mg.kg(-1) over 10 s. The bolus dose of remifentanil was determined by a modified Dixon's up-and-down method, starting from 0.5 microg.kg(-1) (0.1 microg.kg(-1) as a step size). Laryngeal mask insertion was attempted 90 s after the end of remifentanil injection and the response of patients was classified as either 'movement' or 'no movement'. The bolus dose of remifentanil at which there was a 50% probability of successful laryngeal mask insertion (ED(50)) during induction with 2.5 mg.kg(-1) propofol was 0.56 (0.07) microg.kg(-1) in children without a neuromuscular blocking agent. From probit analysis, the ED(50) and ED(95) of remifentanil were 0.52 microg.kg(-1) (95% confidence limits, 0.42-0.62 microg.kg(-1)) and 0.71 microg.kg(-1) (95% confidence limits, 0.61-1.40 microg.kg(-1)), respectively.

Authors+Show Affiliations

Department of Anaesthesiology and Pain Medicine, Gachon University of Science and Medicine, Gil Medical Center, Incheon, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18557970

Citation

Kwak, H J., et al. "The Optimum Bolus Dose of Remifentanil to Facilitate Laryngeal Mask Airway Insertion With a Single Standard Dose of Propofol at Induction in Children." Anaesthesia, vol. 63, no. 9, 2008, pp. 954-8.
Kwak HJ, Kim JY, Kim YB, et al. The optimum bolus dose of remifentanil to facilitate laryngeal mask airway insertion with a single standard dose of propofol at induction in children. Anaesthesia. 2008;63(9):954-8.
Kwak, H. J., Kim, J. Y., Kim, Y. B., Chae, Y. J., & Kim, J. Y. (2008). The optimum bolus dose of remifentanil to facilitate laryngeal mask airway insertion with a single standard dose of propofol at induction in children. Anaesthesia, 63(9), 954-8. https://doi.org/10.1111/j.1365-2044.2008.05544.x
Kwak HJ, et al. The Optimum Bolus Dose of Remifentanil to Facilitate Laryngeal Mask Airway Insertion With a Single Standard Dose of Propofol at Induction in Children. Anaesthesia. 2008;63(9):954-8. PubMed PMID: 18557970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The optimum bolus dose of remifentanil to facilitate laryngeal mask airway insertion with a single standard dose of propofol at induction in children. AU - Kwak,H J, AU - Kim,J Y, AU - Kim,Y B, AU - Chae,Y J, AU - Kim,J Y, Y1 - 2008/06/28/ PY - 2008/6/19/pubmed PY - 2008/9/5/medline PY - 2008/6/19/entrez SP - 954 EP - 8 JF - Anaesthesia JO - Anaesthesia VL - 63 IS - 9 N2 - The purpose of this study was to determine the optimal bolus dose of remifentanil required for the successful insertion of the laryngeal mask airway during propofol induction in children without a neuromuscular blocking agent. Twenty-six paediatric patients, aged 3-10 years, requiring anaesthesia for short ambulatory surgery were recruited. A predetermined bolus dose of remifentanil was injected over 30 s, followed by propofol 2.5 mg.kg(-1) over 10 s. The bolus dose of remifentanil was determined by a modified Dixon's up-and-down method, starting from 0.5 microg.kg(-1) (0.1 microg.kg(-1) as a step size). Laryngeal mask insertion was attempted 90 s after the end of remifentanil injection and the response of patients was classified as either 'movement' or 'no movement'. The bolus dose of remifentanil at which there was a 50% probability of successful laryngeal mask insertion (ED(50)) during induction with 2.5 mg.kg(-1) propofol was 0.56 (0.07) microg.kg(-1) in children without a neuromuscular blocking agent. From probit analysis, the ED(50) and ED(95) of remifentanil were 0.52 microg.kg(-1) (95% confidence limits, 0.42-0.62 microg.kg(-1)) and 0.71 microg.kg(-1) (95% confidence limits, 0.61-1.40 microg.kg(-1)), respectively. SN - 1365-2044 UR - https://www.unboundmedicine.com/medline/citation/18557970/The_optimum_bolus_dose_of_remifentanil_to_facilitate_laryngeal_mask_airway_insertion_with_a_single_standard_dose_of_propofol_at_induction_in_children_ L2 - https://doi.org/10.1111/j.1365-2044.2008.05544.x DB - PRIME DP - Unbound Medicine ER -