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Rapid nondestructive on-site screening of methylamphetamine seizures by attenuated total reflection fourier transform infrared spectroscopy.
Appl Spectrosc. 2008 Jun; 62(6):640-8.AS

Abstract

The identification and quantification of illicit substances in the field is often desirable. Fourier transform infrared spectroscopy (FT-IR) has both qualitative and quantitative capabilities and field portable instruments are commercially available. Transmission infrared spectra of mixtures containing ephedrine hydrochloride, glucose, and caffeine and attenuated total reflection (ATR) infrared spectra of mixtures composed of methylamphetamine hydrochloride, glucose, and caffeine were used to develop principal component regression (PCR) calibration models. The root mean sum of errors of predictions (RMSEP) of all individual components in a mixture from a single measurement was <6% w/w, which reduced to approximately 3% w/w when triplicates were averaged. Sample mixing and grinding are essential to minimize the effect of heterogeneity, as deviations of up to 20% w/w were observed for single measurements of unground samples. Poor predictions of the components in a mixture occurred when samples were "contaminated" with substances not present in the calibration set, as would be expected. When only a single analyte (drug) was targeted, using a calibration set that contained both contaminated and uncontaminated samples, an RMSEP of approximately 4% w/w was achieved. The results demonstrate that ATR-FT-IR has the potential to quantify methylamphetamine samples, and possibly other licit or illicit substances, in at-seizure and on-site scenarios.

Authors+Show Affiliations

Department of Applied Chemistry, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18559151

Citation

Goh, Ching Yong, et al. "Rapid Nondestructive On-site Screening of Methylamphetamine Seizures By Attenuated Total Reflection Fourier Transform Infrared Spectroscopy." Applied Spectroscopy, vol. 62, no. 6, 2008, pp. 640-8.
Goh CY, van Bronswijk W, Priddis C. Rapid nondestructive on-site screening of methylamphetamine seizures by attenuated total reflection fourier transform infrared spectroscopy. Appl Spectrosc. 2008;62(6):640-8.
Goh, C. Y., van Bronswijk, W., & Priddis, C. (2008). Rapid nondestructive on-site screening of methylamphetamine seizures by attenuated total reflection fourier transform infrared spectroscopy. Applied Spectroscopy, 62(6), 640-8. https://doi.org/10.1366/000370208784658002
Goh CY, van Bronswijk W, Priddis C. Rapid Nondestructive On-site Screening of Methylamphetamine Seizures By Attenuated Total Reflection Fourier Transform Infrared Spectroscopy. Appl Spectrosc. 2008;62(6):640-8. PubMed PMID: 18559151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid nondestructive on-site screening of methylamphetamine seizures by attenuated total reflection fourier transform infrared spectroscopy. AU - Goh,Ching Yong, AU - van Bronswijk,Wilhelm, AU - Priddis,Colin, PY - 2008/6/19/pubmed PY - 2008/8/2/medline PY - 2008/6/19/entrez SP - 640 EP - 8 JF - Applied spectroscopy JO - Appl Spectrosc VL - 62 IS - 6 N2 - The identification and quantification of illicit substances in the field is often desirable. Fourier transform infrared spectroscopy (FT-IR) has both qualitative and quantitative capabilities and field portable instruments are commercially available. Transmission infrared spectra of mixtures containing ephedrine hydrochloride, glucose, and caffeine and attenuated total reflection (ATR) infrared spectra of mixtures composed of methylamphetamine hydrochloride, glucose, and caffeine were used to develop principal component regression (PCR) calibration models. The root mean sum of errors of predictions (RMSEP) of all individual components in a mixture from a single measurement was <6% w/w, which reduced to approximately 3% w/w when triplicates were averaged. Sample mixing and grinding are essential to minimize the effect of heterogeneity, as deviations of up to 20% w/w were observed for single measurements of unground samples. Poor predictions of the components in a mixture occurred when samples were "contaminated" with substances not present in the calibration set, as would be expected. When only a single analyte (drug) was targeted, using a calibration set that contained both contaminated and uncontaminated samples, an RMSEP of approximately 4% w/w was achieved. The results demonstrate that ATR-FT-IR has the potential to quantify methylamphetamine samples, and possibly other licit or illicit substances, in at-seizure and on-site scenarios. SN - 0003-7028 UR - https://www.unboundmedicine.com/medline/citation/18559151/Rapid_nondestructive_on_site_screening_of_methylamphetamine_seizures_by_attenuated_total_reflection_fourier_transform_infrared_spectroscopy_ L2 - http://journals.sagepub.com/doi/full/10.1366/000370208784658002?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -