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The relationship of coffee consumption with mortality.
Ann Intern Med 2008; 148(12):904-14AIM

Abstract

BACKGROUND

Coffee consumption has been linked to various beneficial and detrimental health effects, but data on its relation with mortality are sparse.

OBJECTIVE

To assess the association between coffee consumption and mortality from cardiovascular disease (CVD), cancer, and all causes during 18 years of follow-up in men and 24 years of follow-up in women.

DESIGN

Sex-specific Cox proportional hazard models were used to investigate the association between coffee consumption and incidence of all-cause and disease-specific mortality in a prospective cohort study.

SETTING

Health Professionals Follow-up Study and Nurses' Health Study.

PARTICIPANTS

41,736 men and 86,214 women with no history of CVD or cancer at baseline.

MEASUREMENTS

Coffee consumption was assessed first in 1986 for men and in 1980 for women and then every 2 to 4 years through 2004. Investigators documented 6888 deaths (2049 due to CVD and 2491 due to cancer) among men and 11,095 deaths (2368 due to CVD and 5011 due to cancer) among women.

RESULTS

After adjustment for age, smoking, and other CVD and cancer risk factors, the relative risks for all-cause mortality in men across categories of coffee consumption (<1 cup per month, 1 cup per month to 4 cups per week, 5 to 7 cups per week, 2 to 3 cups per day, 4 to 5 cups per day, and >or=6 cups per day) were 1.0, 1.07 (95% CI, 0.99 to 1.16), 1.02 (CI, 0.95 to 1.11), 0.97 (CI, 0.89 to 1.05), 0.93 (CI, 0.81 to 1.07), and 0.80 (CI, 0.62 to 1.04), respectively (P for trend = 0.008). For women, the relative risks were 1.0, 0.98 (CI, 0.91 to 1.05), 0.93 (CI, 0.87 to 0.98), 0.82 (CI, 0.77 to 0.87), 0.74 (CI, 0.68 to 0.81), and 0.83 (CI, 0.73 to 0.95), respectively (P for trend < 0.001). This inverse association was mainly due to a moderately reduced risk for CVD mortality and was independent of caffeine intake. By contrast, coffee consumption was not statistically significantly associated with risk for cancer death after adjustment for potential confounders. Decaffeinated coffee consumption was associated with a small reduction in all-cause and CVD mortality.

LIMITATION

Coffee consumption was estimated from self-report; thus, some measurement error is inevitable.

CONCLUSION

Regular coffee consumption was not associated with an increased mortality rate in either men or women. The possibility of a modest benefit of coffee consumption on all-cause and CVD mortality needs to be further investigated.

Authors+Show Affiliations

Harvard School of Public Health, Brigham and Women's Hospital, Boston, Massachussetts, USA. esther.lopez@uam.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18559841

Citation

Lopez-Garcia, Esther, et al. "The Relationship of Coffee Consumption With Mortality." Annals of Internal Medicine, vol. 148, no. 12, 2008, pp. 904-14.
Lopez-Garcia E, van Dam RM, Li TY, et al. The relationship of coffee consumption with mortality. Ann Intern Med. 2008;148(12):904-14.
Lopez-Garcia, E., van Dam, R. M., Li, T. Y., Rodriguez-Artalejo, F., & Hu, F. B. (2008). The relationship of coffee consumption with mortality. Annals of Internal Medicine, 148(12), pp. 904-14.
Lopez-Garcia E, et al. The Relationship of Coffee Consumption With Mortality. Ann Intern Med. 2008 Jun 17;148(12):904-14. PubMed PMID: 18559841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship of coffee consumption with mortality. AU - Lopez-Garcia,Esther, AU - van Dam,Rob M, AU - Li,Tricia Y, AU - Rodriguez-Artalejo,Fernando, AU - Hu,Frank B, PY - 2008/6/19/pubmed PY - 2008/6/24/medline PY - 2008/6/19/entrez SP - 904 EP - 14 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 148 IS - 12 N2 - BACKGROUND: Coffee consumption has been linked to various beneficial and detrimental health effects, but data on its relation with mortality are sparse. OBJECTIVE: To assess the association between coffee consumption and mortality from cardiovascular disease (CVD), cancer, and all causes during 18 years of follow-up in men and 24 years of follow-up in women. DESIGN: Sex-specific Cox proportional hazard models were used to investigate the association between coffee consumption and incidence of all-cause and disease-specific mortality in a prospective cohort study. SETTING: Health Professionals Follow-up Study and Nurses' Health Study. PARTICIPANTS: 41,736 men and 86,214 women with no history of CVD or cancer at baseline. MEASUREMENTS: Coffee consumption was assessed first in 1986 for men and in 1980 for women and then every 2 to 4 years through 2004. Investigators documented 6888 deaths (2049 due to CVD and 2491 due to cancer) among men and 11,095 deaths (2368 due to CVD and 5011 due to cancer) among women. RESULTS: After adjustment for age, smoking, and other CVD and cancer risk factors, the relative risks for all-cause mortality in men across categories of coffee consumption (<1 cup per month, 1 cup per month to 4 cups per week, 5 to 7 cups per week, 2 to 3 cups per day, 4 to 5 cups per day, and >or=6 cups per day) were 1.0, 1.07 (95% CI, 0.99 to 1.16), 1.02 (CI, 0.95 to 1.11), 0.97 (CI, 0.89 to 1.05), 0.93 (CI, 0.81 to 1.07), and 0.80 (CI, 0.62 to 1.04), respectively (P for trend = 0.008). For women, the relative risks were 1.0, 0.98 (CI, 0.91 to 1.05), 0.93 (CI, 0.87 to 0.98), 0.82 (CI, 0.77 to 0.87), 0.74 (CI, 0.68 to 0.81), and 0.83 (CI, 0.73 to 0.95), respectively (P for trend < 0.001). This inverse association was mainly due to a moderately reduced risk for CVD mortality and was independent of caffeine intake. By contrast, coffee consumption was not statistically significantly associated with risk for cancer death after adjustment for potential confounders. Decaffeinated coffee consumption was associated with a small reduction in all-cause and CVD mortality. LIMITATION: Coffee consumption was estimated from self-report; thus, some measurement error is inevitable. CONCLUSION: Regular coffee consumption was not associated with an increased mortality rate in either men or women. The possibility of a modest benefit of coffee consumption on all-cause and CVD mortality needs to be further investigated. SN - 1539-3704 UR - https://www.unboundmedicine.com/medline/citation/18559841/The_relationship_of_coffee_consumption_with_mortality_ L2 - https://www.annals.org/article.aspx?volume=148&amp;issue=12&amp;page=904 DB - PRIME DP - Unbound Medicine ER -