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Lymphangiogenesis and its relationship with lymphatic metastasis and prognosis in malignant melanoma.
Anat Rec (Hoboken). 2008 Oct; 291(10):1227-35.AR

Abstract

Regional lymph node metastasis is one of the important indicators of cutaneous malignant melanoma. Newly formed lymphatic vessels are considered to provide a route whereby tumor cells can migrate to the lymph nodes. Both vascular endothelial growth factors (VEGF) -C and -D have been confirmed to participate in tumor lymphangiogenesis, but the prognostic significance of VEGF-C, VEGF-D, and lymphangiogenesis in cutaneous malignant melanoma remains controversial. To clarify the effects of these factors and to evaluate the relationships between lymphangiogenesis, lymph node metastasis, and prognosis in patients with malignant melanoma, the expressions of VEGF-C, VEGF-D, and their receptor (VEGFR) -3 were detected by immunohistochemistry and reverse transcriptase-polymerase chain reaction. The expressions of both VEGF-C and VEGF-D proteins were concomitantly detected in the cytoplasm of the malignant cells. VEGF-C and VEGF-D expressions were associated with VEGFR-3 expression and were significantly correlated with both peritumoral lymphangiogenesis and lymph node metastasis. The incidence of peritumoral lymphatic vessels was significantly higher in lymph node metastatic melanomas than that in nonmetastatic melanomas. Univariate and multivariate analyses indicated that VEGF-C and VEGF-D were independent prognostic factors for overall survival and disease-free survival in patients with malignant melanoma. This study suggests that both VEGF-C and VEGF-D are involved in peritumoral lymphangiogenesis and lymphatic metastasis. VEGF-C and VEGF-D expression may be clinically useful indicators for prognostic evaluation in patients with cutaneous malignant melanoma.

Authors+Show Affiliations

Department of Anatomy, Harbin Medical University, Harbin, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18561194

Citation

Liu, Baoquan, et al. "Lymphangiogenesis and Its Relationship With Lymphatic Metastasis and Prognosis in Malignant Melanoma." Anatomical Record (Hoboken, N.J. : 2007), vol. 291, no. 10, 2008, pp. 1227-35.
Liu B, Ma J, Wang X, et al. Lymphangiogenesis and its relationship with lymphatic metastasis and prognosis in malignant melanoma. Anat Rec (Hoboken). 2008;291(10):1227-35.
Liu, B., Ma, J., Wang, X., Su, F., Li, X., Yang, S., Ma, W., & Zhang, Y. (2008). Lymphangiogenesis and its relationship with lymphatic metastasis and prognosis in malignant melanoma. Anatomical Record (Hoboken, N.J. : 2007), 291(10), 1227-35. https://doi.org/10.1002/ar.20736
Liu B, et al. Lymphangiogenesis and Its Relationship With Lymphatic Metastasis and Prognosis in Malignant Melanoma. Anat Rec (Hoboken). 2008;291(10):1227-35. PubMed PMID: 18561194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lymphangiogenesis and its relationship with lymphatic metastasis and prognosis in malignant melanoma. AU - Liu,Baoquan, AU - Ma,Jing, AU - Wang,Xiaolei, AU - Su,Fei, AU - Li,Xuemei, AU - Yang,Shucai, AU - Ma,Wenping, AU - Zhang,Yafang, PY - 2008/6/19/pubmed PY - 2008/11/7/medline PY - 2008/6/19/entrez SP - 1227 EP - 35 JF - Anatomical record (Hoboken, N.J. : 2007) JO - Anat Rec (Hoboken) VL - 291 IS - 10 N2 - Regional lymph node metastasis is one of the important indicators of cutaneous malignant melanoma. Newly formed lymphatic vessels are considered to provide a route whereby tumor cells can migrate to the lymph nodes. Both vascular endothelial growth factors (VEGF) -C and -D have been confirmed to participate in tumor lymphangiogenesis, but the prognostic significance of VEGF-C, VEGF-D, and lymphangiogenesis in cutaneous malignant melanoma remains controversial. To clarify the effects of these factors and to evaluate the relationships between lymphangiogenesis, lymph node metastasis, and prognosis in patients with malignant melanoma, the expressions of VEGF-C, VEGF-D, and their receptor (VEGFR) -3 were detected by immunohistochemistry and reverse transcriptase-polymerase chain reaction. The expressions of both VEGF-C and VEGF-D proteins were concomitantly detected in the cytoplasm of the malignant cells. VEGF-C and VEGF-D expressions were associated with VEGFR-3 expression and were significantly correlated with both peritumoral lymphangiogenesis and lymph node metastasis. The incidence of peritumoral lymphatic vessels was significantly higher in lymph node metastatic melanomas than that in nonmetastatic melanomas. Univariate and multivariate analyses indicated that VEGF-C and VEGF-D were independent prognostic factors for overall survival and disease-free survival in patients with malignant melanoma. This study suggests that both VEGF-C and VEGF-D are involved in peritumoral lymphangiogenesis and lymphatic metastasis. VEGF-C and VEGF-D expression may be clinically useful indicators for prognostic evaluation in patients with cutaneous malignant melanoma. SN - 1932-8494 UR - https://www.unboundmedicine.com/medline/citation/18561194/Lymphangiogenesis_and_its_relationship_with_lymphatic_metastasis_and_prognosis_in_malignant_melanoma_ L2 - https://doi.org/10.1002/ar.20736 DB - PRIME DP - Unbound Medicine ER -