Tags

Type your tag names separated by a space and hit enter

Study of anemia in long-term care (SALT): prevalence of anemia and its relationship with the risk of falls in nursing home residents.
Curr Med Res Opin. 2008 Aug; 24(8):2139-49.CM

Abstract

OBJECTIVE

The objectives of the current study were twofold. First, this study examined the prevalence of anemia in nursing home residents in the USA and its relationship with key resident characteristics and medical conditions. Second, the study explored whether an association between anemia and falls is evident in this same population.

RESEARCH DESIGN AND METHODS

Chart review was conducted in 40 nursing homes across the USA. Residents were randomly sampled and considered eligible if they: were > or =18 years of age; had > or =1 hemoglobin (Hb) level reported during the data uptake period of 1/1/04-2/1/05 (first occurrence defined as index Hb); had a recorded serum creatinine level; maintained residency in the facility; and did not receive dialysis during the 6-month post-index follow-up period. Resident demographics, laboratory values, comorbid conditions, medication regimens, falling events, physical functioning measures, and hospitalizations were obtained from chart data. The relationship between selected resident characteristics and comorbidities was explored with index Hb level, using multiple linear regression. Logistic regression was used to analyze the relationship between falling and recurrent falls with anemia (index Hb < 13 g/dL and < 12 g/dL in men and women > or =15 years, respectively) adjusting for selected variables presumed to be related to falls.

LIMITATIONS

Study limitations include the retrospective design and limited follow-up, potential for biased selection of relevant covariates, gaps in time between index Hb levels and falling events, non-random selection of nursing homes, limits to quality and detail in data extracted from residents' medical charts, and confounding of anemia therapy with index hemoglobin level.

RESULTS

A total of 564 sampled residents met the criteria for data completeness and were retained for analysis; of these, 70% were female. Mean age was 81 +/- 12.3 years (+/-SD). Mean index Hb level was 11.9 +/- 1.8 g/dL (12.2 +/- 2.0 for males, 11.7 +/- 1.6 for females). Of all residents studied, 56% were identified as anemic (64% males, 53% females) from index Hb level. In all, 53% of anemic residents were receiving an identified therapy, with 72% of these treated residents receiving iron. None received an erythropoietic-stimulating agent (ESA). For index Hb level, the regression coefficient was significant for female (p = 0.002), African-American race (p = 0.012), glomerular filtration rate (GFR) < 60 mL/min/1.73 m(2) (p < 0.001), diabetes (p = 0.004), cancer (p < 0.001), asthma (p = 0.002), GI bleeding (p = 0.012), and inflammatory disease (p = 0.039). Except for asthma, these factors were associated with a decrease in Hb. In the regression model for the dependent variable of falling, anemia (OR = 2.26, p = 0.001), psychoactive medication use (OR = 2.18, p = 0.001), and age 85+ years (OR = 2.08, p = 0.016) were associated with more than twice the risk of falling.

CONCLUSIONS

Anemia in nursing home residents appears to be under-recognized. For residents over 70 years, the prevalence of anemia in both male and female residents was approximately four times the rate reported in a study of older community dwellers (Salive et al., 1992). Both anemia and the use of psychoactive medications are potentially modifiable factors strongly associated with falling. Since falls and related fractures are events associated with high morbidity and mortality, each of these factors deserves special consideration for potentially reducing the risk of such events in the nursing home.

Authors+Show Affiliations

Department of Geriatrics, Nova Southeastern University College of Osteopathic Medicine, Ft. Lauderdale, FL, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18561876

Citation

Pandya, Naushira, et al. "Study of Anemia in Long-term Care (SALT): Prevalence of Anemia and Its Relationship With the Risk of Falls in Nursing Home Residents." Current Medical Research and Opinion, vol. 24, no. 8, 2008, pp. 2139-49.
Pandya N, Bookhart B, Mody SH, et al. Study of anemia in long-term care (SALT): prevalence of anemia and its relationship with the risk of falls in nursing home residents. Curr Med Res Opin. 2008;24(8):2139-49.
Pandya, N., Bookhart, B., Mody, S. H., Funk Orsini, P. A., & Reardon, G. (2008). Study of anemia in long-term care (SALT): prevalence of anemia and its relationship with the risk of falls in nursing home residents. Current Medical Research and Opinion, 24(8), 2139-49. https://doi.org/10.1185/03007990802215844
Pandya N, et al. Study of Anemia in Long-term Care (SALT): Prevalence of Anemia and Its Relationship With the Risk of Falls in Nursing Home Residents. Curr Med Res Opin. 2008;24(8):2139-49. PubMed PMID: 18561876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of anemia in long-term care (SALT): prevalence of anemia and its relationship with the risk of falls in nursing home residents. AU - Pandya,Naushira, AU - Bookhart,Brahim, AU - Mody,Samir H, AU - Funk Orsini,Paula A, AU - Reardon,Gregory, Y1 - 2008/06/17/ PY - 2008/6/20/pubmed PY - 2008/12/30/medline PY - 2008/6/20/entrez SP - 2139 EP - 49 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 24 IS - 8 N2 - OBJECTIVE: The objectives of the current study were twofold. First, this study examined the prevalence of anemia in nursing home residents in the USA and its relationship with key resident characteristics and medical conditions. Second, the study explored whether an association between anemia and falls is evident in this same population. RESEARCH DESIGN AND METHODS: Chart review was conducted in 40 nursing homes across the USA. Residents were randomly sampled and considered eligible if they: were > or =18 years of age; had > or =1 hemoglobin (Hb) level reported during the data uptake period of 1/1/04-2/1/05 (first occurrence defined as index Hb); had a recorded serum creatinine level; maintained residency in the facility; and did not receive dialysis during the 6-month post-index follow-up period. Resident demographics, laboratory values, comorbid conditions, medication regimens, falling events, physical functioning measures, and hospitalizations were obtained from chart data. The relationship between selected resident characteristics and comorbidities was explored with index Hb level, using multiple linear regression. Logistic regression was used to analyze the relationship between falling and recurrent falls with anemia (index Hb < 13 g/dL and < 12 g/dL in men and women > or =15 years, respectively) adjusting for selected variables presumed to be related to falls. LIMITATIONS: Study limitations include the retrospective design and limited follow-up, potential for biased selection of relevant covariates, gaps in time between index Hb levels and falling events, non-random selection of nursing homes, limits to quality and detail in data extracted from residents' medical charts, and confounding of anemia therapy with index hemoglobin level. RESULTS: A total of 564 sampled residents met the criteria for data completeness and were retained for analysis; of these, 70% were female. Mean age was 81 +/- 12.3 years (+/-SD). Mean index Hb level was 11.9 +/- 1.8 g/dL (12.2 +/- 2.0 for males, 11.7 +/- 1.6 for females). Of all residents studied, 56% were identified as anemic (64% males, 53% females) from index Hb level. In all, 53% of anemic residents were receiving an identified therapy, with 72% of these treated residents receiving iron. None received an erythropoietic-stimulating agent (ESA). For index Hb level, the regression coefficient was significant for female (p = 0.002), African-American race (p = 0.012), glomerular filtration rate (GFR) < 60 mL/min/1.73 m(2) (p < 0.001), diabetes (p = 0.004), cancer (p < 0.001), asthma (p = 0.002), GI bleeding (p = 0.012), and inflammatory disease (p = 0.039). Except for asthma, these factors were associated with a decrease in Hb. In the regression model for the dependent variable of falling, anemia (OR = 2.26, p = 0.001), psychoactive medication use (OR = 2.18, p = 0.001), and age 85+ years (OR = 2.08, p = 0.016) were associated with more than twice the risk of falling. CONCLUSIONS: Anemia in nursing home residents appears to be under-recognized. For residents over 70 years, the prevalence of anemia in both male and female residents was approximately four times the rate reported in a study of older community dwellers (Salive et al., 1992). Both anemia and the use of psychoactive medications are potentially modifiable factors strongly associated with falling. Since falls and related fractures are events associated with high morbidity and mortality, each of these factors deserves special consideration for potentially reducing the risk of such events in the nursing home. SN - 1473-4877 UR - https://www.unboundmedicine.com/medline/citation/18561876/Study_of_anemia_in_long_term_care__SALT_:_prevalence_of_anemia_and_its_relationship_with_the_risk_of_falls_in_nursing_home_residents_ L2 - https://www.tandfonline.com/doi/full/10.1185/03007990802215844 DB - PRIME DP - Unbound Medicine ER -