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Age-related changes in fatty acids from different adipose depots in rat and their association with adiposity and insulin.
Nutrition. 2008 Oct; 24(10):1013-22.N

Abstract

OBJECTIVE

We studied age-related changes in fatty acids (FAs) from serum and adipose tissue in rats by comparing different adipose regions and analyzed their relations to adiposity and insulin function.

METHODS

Female weaned rats were fed on a high-fat diet until 6, 14, and 20 mo of age (n = 12, n = 6, n = 10, respectively). Body weight, adiposity, serum insulin, serum glucose, and homeostatic model assessment index were measured. FA compositions from serum and interscapular brown, periovarian, mesenteric, and subcutaneous tissues were determined by gas chromatography.

RESULTS

Body weight and adiposity increased with age; visceral depots grew by hypertrophy, whereas subcutaneous depots grew by hyperplasia and in a higher ratio. Initially, the mesenteric tissue showed greater saturated and trans-FA contents, whereas brown tissue had higher polyunsaturated FA (PUFA) proportions. Aging resulted in a lower saturation degree in adipose tissue, attenuating earlier differences among depots. There was an elevation in omega-6 PUFAs with age, mainly because of C18:2omega-6, whereas omega-3 long-chain PUFAs, C20:5omega-3 and C22:6omega-3, tended to decrease in serum and adipose tissue. Adiposity was associated positively with monounsaturated FAs and inversely with PUFAs; insulin-related variables correlated negatively with serum omega-6 PUFA but positively with serum monounsaturated FAs and subcutaneous depot trans-FAs.

CONCLUSION

The mesenteric tissue showed the least favorable FA profile compared with the other depots, but differences among adipose regions diminished with age. In rats fed a high-fat diet, aging resulted in a lower saturation degree, with increased values in the cardiometabolic risk factor omega-6/omega-3 ratio in serum and adipose tissue.

Authors+Show Affiliations

Department of Physiology, University of Murcia, Murcia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18562171

Citation

de Heredia, Fátima Pérez, et al. "Age-related Changes in Fatty Acids From Different Adipose Depots in Rat and Their Association With Adiposity and Insulin." Nutrition (Burbank, Los Angeles County, Calif.), vol. 24, no. 10, 2008, pp. 1013-22.
de Heredia FP, Larque E, Portillo MP, et al. Age-related changes in fatty acids from different adipose depots in rat and their association with adiposity and insulin. Nutrition. 2008;24(10):1013-22.
de Heredia, F. P., Larque, E., Portillo, M. P., Canteras, M., Zamora, S., & Garaulet, M. (2008). Age-related changes in fatty acids from different adipose depots in rat and their association with adiposity and insulin. Nutrition (Burbank, Los Angeles County, Calif.), 24(10), 1013-22. https://doi.org/10.1016/j.nut.2008.03.022
de Heredia FP, et al. Age-related Changes in Fatty Acids From Different Adipose Depots in Rat and Their Association With Adiposity and Insulin. Nutrition. 2008;24(10):1013-22. PubMed PMID: 18562171.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related changes in fatty acids from different adipose depots in rat and their association with adiposity and insulin. AU - de Heredia,Fátima Pérez, AU - Larque,Elvira, AU - Portillo,Maria Del Puy, AU - Canteras,Manuel, AU - Zamora,Salvador, AU - Garaulet,Marta, Y1 - 2008/06/17/ PY - 2007/12/13/received PY - 2008/03/06/revised PY - 2008/03/25/accepted PY - 2008/6/20/pubmed PY - 2009/2/5/medline PY - 2008/6/20/entrez SP - 1013 EP - 22 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 24 IS - 10 N2 - OBJECTIVE: We studied age-related changes in fatty acids (FAs) from serum and adipose tissue in rats by comparing different adipose regions and analyzed their relations to adiposity and insulin function. METHODS: Female weaned rats were fed on a high-fat diet until 6, 14, and 20 mo of age (n = 12, n = 6, n = 10, respectively). Body weight, adiposity, serum insulin, serum glucose, and homeostatic model assessment index were measured. FA compositions from serum and interscapular brown, periovarian, mesenteric, and subcutaneous tissues were determined by gas chromatography. RESULTS: Body weight and adiposity increased with age; visceral depots grew by hypertrophy, whereas subcutaneous depots grew by hyperplasia and in a higher ratio. Initially, the mesenteric tissue showed greater saturated and trans-FA contents, whereas brown tissue had higher polyunsaturated FA (PUFA) proportions. Aging resulted in a lower saturation degree in adipose tissue, attenuating earlier differences among depots. There was an elevation in omega-6 PUFAs with age, mainly because of C18:2omega-6, whereas omega-3 long-chain PUFAs, C20:5omega-3 and C22:6omega-3, tended to decrease in serum and adipose tissue. Adiposity was associated positively with monounsaturated FAs and inversely with PUFAs; insulin-related variables correlated negatively with serum omega-6 PUFA but positively with serum monounsaturated FAs and subcutaneous depot trans-FAs. CONCLUSION: The mesenteric tissue showed the least favorable FA profile compared with the other depots, but differences among adipose regions diminished with age. In rats fed a high-fat diet, aging resulted in a lower saturation degree, with increased values in the cardiometabolic risk factor omega-6/omega-3 ratio in serum and adipose tissue. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/18562171/Age_related_changes_in_fatty_acids_from_different_adipose_depots_in_rat_and_their_association_with_adiposity_and_insulin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(08)00173-1 DB - PRIME DP - Unbound Medicine ER -