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Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I.
Clin Vaccine Immunol 2008; 15(8):1171-5CV

Abstract

To investigate whether protective immune responses can be induced in the absence of normal interleukin-12/23/gamma interferon (IL-12/23/IFN-gamma) axis signaling, we vaccinated with the seasonal influenza virus subunit vaccine two patients with complete IL-12/23 receptor beta1 (IL-12/23R beta 1) deficiencies, two patients with partial IFN-gamma receptor I (pIFN-gamma RI) deficiencies, and five healthy controls. Blood samples were analyzed before, 7 days after, and 28 days after vaccination. In most cases, antibody titers reached protective levels. Moreover, although T-cell responses in patients were lower than those observed in controls, significant influenza virus-specific T-cell proliferation, IFN-gamma production, and numbers of IFN-gamma-producing cells were found in all patients 7 days after the vaccination. Interestingly, influenza virus-specific IFN-gamma responses were IL-12/23 independent, in striking contrast to mycobacterium-induced IFN-gamma production. In conclusion, influenza virus vaccination induces IL-12/23-independent IFN-gamma production by T cells and can result in sufficient humoral protection in both IL-12/23R beta 1- and pIFN-gamma RI-deficient individuals.

Authors+Show Affiliations

Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18562567

Citation

de Boer, Tjitske, et al. "Influenza Virus Vaccination Induces Interleukin-12/23 Receptor Beta 1 (IL-12/23R Beta 1)-independent Production of Gamma Interferon (IFN-gamma) and Humoral Immunity in Patients With Genetic Deficiencies in IL-12/23R Beta 1 or IFN-gamma Receptor I." Clinical and Vaccine Immunology : CVI, vol. 15, no. 8, 2008, pp. 1171-5.
de Boer T, van Dissel JT, Kuijpers TW, et al. Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I. Clin Vaccine Immunol. 2008;15(8):1171-5.
de Boer, T., van Dissel, J. T., Kuijpers, T. W., Rimmelzwaan, G. F., Kroon, F. P., & Ottenhoff, T. H. (2008). Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I. Clinical and Vaccine Immunology : CVI, 15(8), pp. 1171-5. doi:10.1128/CVI.00090-08.
de Boer T, et al. Influenza Virus Vaccination Induces Interleukin-12/23 Receptor Beta 1 (IL-12/23R Beta 1)-independent Production of Gamma Interferon (IFN-gamma) and Humoral Immunity in Patients With Genetic Deficiencies in IL-12/23R Beta 1 or IFN-gamma Receptor I. Clin Vaccine Immunol. 2008;15(8):1171-5. PubMed PMID: 18562567.
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TY - JOUR T1 - Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I. AU - de Boer,Tjitske, AU - van Dissel,Jaap T, AU - Kuijpers,Taco W J, AU - Rimmelzwaan,Guus F, AU - Kroon,Frank P, AU - Ottenhoff,Tom H M, Y1 - 2008/06/18/ PY - 2008/6/20/pubmed PY - 2008/10/8/medline PY - 2008/6/20/entrez SP - 1171 EP - 5 JF - Clinical and vaccine immunology : CVI JO - Clin. Vaccine Immunol. VL - 15 IS - 8 N2 - To investigate whether protective immune responses can be induced in the absence of normal interleukin-12/23/gamma interferon (IL-12/23/IFN-gamma) axis signaling, we vaccinated with the seasonal influenza virus subunit vaccine two patients with complete IL-12/23 receptor beta1 (IL-12/23R beta 1) deficiencies, two patients with partial IFN-gamma receptor I (pIFN-gamma RI) deficiencies, and five healthy controls. Blood samples were analyzed before, 7 days after, and 28 days after vaccination. In most cases, antibody titers reached protective levels. Moreover, although T-cell responses in patients were lower than those observed in controls, significant influenza virus-specific T-cell proliferation, IFN-gamma production, and numbers of IFN-gamma-producing cells were found in all patients 7 days after the vaccination. Interestingly, influenza virus-specific IFN-gamma responses were IL-12/23 independent, in striking contrast to mycobacterium-induced IFN-gamma production. In conclusion, influenza virus vaccination induces IL-12/23-independent IFN-gamma production by T cells and can result in sufficient humoral protection in both IL-12/23R beta 1- and pIFN-gamma RI-deficient individuals. SN - 1556-679X UR - https://www.unboundmedicine.com/medline/citation/18562567/Influenza_virus_vaccination_induces_interleukin_12/23_receptor_beta_1__IL_12/23R_beta_1__independent_production_of_gamma_interferon__IFN_gamma__and_humoral_immunity_in_patients_with_genetic_deficiencies_in_IL_12/23R_beta_1_or_IFN_gamma_receptor_I_ L2 - http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=18562567 DB - PRIME DP - Unbound Medicine ER -