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Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I.

Abstract

To investigate whether protective immune responses can be induced in the absence of normal interleukin-12/23/gamma interferon (IL-12/23/IFN-gamma) axis signaling, we vaccinated with the seasonal influenza virus subunit vaccine two patients with complete IL-12/23 receptor beta1 (IL-12/23R beta 1) deficiencies, two patients with partial IFN-gamma receptor I (pIFN-gamma RI) deficiencies, and five healthy controls. Blood samples were analyzed before, 7 days after, and 28 days after vaccination. In most cases, antibody titers reached protective levels. Moreover, although T-cell responses in patients were lower than those observed in controls, significant influenza virus-specific T-cell proliferation, IFN-gamma production, and numbers of IFN-gamma-producing cells were found in all patients 7 days after the vaccination. Interestingly, influenza virus-specific IFN-gamma responses were IL-12/23 independent, in striking contrast to mycobacterium-induced IFN-gamma production. In conclusion, influenza virus vaccination induces IL-12/23-independent IFN-gamma production by T cells and can result in sufficient humoral protection in both IL-12/23R beta 1- and pIFN-gamma RI-deficient individuals.

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  • Authors+Show Affiliations

    ,

    Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

    , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Antibodies, Viral
    Female
    Humans
    Immunocompromised Host
    Influenza A Virus, H1N1 Subtype
    Influenza A Virus, H3N2 Subtype
    Influenza B virus
    Influenza Vaccines
    Influenza, Human
    Interferon-gamma
    Interleukin-12 Receptor beta 1 Subunit
    Middle Aged
    Receptors, Interferon
    Seasons
    T-Lymphocytes
    Vaccination

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18562567

    Citation

    de Boer, Tjitske, et al. "Influenza Virus Vaccination Induces Interleukin-12/23 Receptor Beta 1 (IL-12/23R Beta 1)-independent Production of Gamma Interferon (IFN-gamma) and Humoral Immunity in Patients With Genetic Deficiencies in IL-12/23R Beta 1 or IFN-gamma Receptor I." Clinical and Vaccine Immunology : CVI, vol. 15, no. 8, 2008, pp. 1171-5.
    de Boer T, van Dissel JT, Kuijpers TW, et al. Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I. Clin Vaccine Immunol. 2008;15(8):1171-5.
    de Boer, T., van Dissel, J. T., Kuijpers, T. W., Rimmelzwaan, G. F., Kroon, F. P., & Ottenhoff, T. H. (2008). Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I. Clinical and Vaccine Immunology : CVI, 15(8), pp. 1171-5. doi:10.1128/CVI.00090-08.
    de Boer T, et al. Influenza Virus Vaccination Induces Interleukin-12/23 Receptor Beta 1 (IL-12/23R Beta 1)-independent Production of Gamma Interferon (IFN-gamma) and Humoral Immunity in Patients With Genetic Deficiencies in IL-12/23R Beta 1 or IFN-gamma Receptor I. Clin Vaccine Immunol. 2008;15(8):1171-5. PubMed PMID: 18562567.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I. AU - de Boer,Tjitske, AU - van Dissel,Jaap T, AU - Kuijpers,Taco W J, AU - Rimmelzwaan,Guus F, AU - Kroon,Frank P, AU - Ottenhoff,Tom H M, Y1 - 2008/06/18/ PY - 2008/6/20/pubmed PY - 2008/10/8/medline PY - 2008/6/20/entrez SP - 1171 EP - 5 JF - Clinical and vaccine immunology : CVI JO - Clin. Vaccine Immunol. VL - 15 IS - 8 N2 - To investigate whether protective immune responses can be induced in the absence of normal interleukin-12/23/gamma interferon (IL-12/23/IFN-gamma) axis signaling, we vaccinated with the seasonal influenza virus subunit vaccine two patients with complete IL-12/23 receptor beta1 (IL-12/23R beta 1) deficiencies, two patients with partial IFN-gamma receptor I (pIFN-gamma RI) deficiencies, and five healthy controls. Blood samples were analyzed before, 7 days after, and 28 days after vaccination. In most cases, antibody titers reached protective levels. Moreover, although T-cell responses in patients were lower than those observed in controls, significant influenza virus-specific T-cell proliferation, IFN-gamma production, and numbers of IFN-gamma-producing cells were found in all patients 7 days after the vaccination. Interestingly, influenza virus-specific IFN-gamma responses were IL-12/23 independent, in striking contrast to mycobacterium-induced IFN-gamma production. In conclusion, influenza virus vaccination induces IL-12/23-independent IFN-gamma production by T cells and can result in sufficient humoral protection in both IL-12/23R beta 1- and pIFN-gamma RI-deficient individuals. SN - 1556-679X UR - https://www.unboundmedicine.com/medline/citation/18562567/Influenza_virus_vaccination_induces_interleukin_12/23_receptor_beta_1__IL_12/23R_beta_1__independent_production_of_gamma_interferon__IFN_gamma__and_humoral_immunity_in_patients_with_genetic_deficiencies_in_IL_12/23R_beta_1_or_IFN_gamma_receptor_I_ L2 - http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=18562567 DB - PRIME DP - Unbound Medicine ER -