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Influence of an antioxidant vitamin-enriched drink on pre- and post-exercise lymphocyte antioxidant system.
Ann Nutr Metab. 2008; 52(3):233-40.AN

Abstract

BACKGROUND/AIMS

Our aim was to determine whether the consumption of a functional drink enriched with vitamin C and vitamin E could alleviate exercise-induced oxidative damage in lymphocytes.

METHODS

Fourteen male amateur trained runners (32-36 years old) were randomized to receive antioxidant supplementation (152 mg vitamin C/day and 50 mg vitamin E/day) or placebo for 1 month in a double-blind study, and participated in a half-marathon race. The volunteers did not take any other antioxidant supplements. Blood samples were taken before and after the half-marathon and after 3 h recovery.

RESULTS

Exercise increased lymphocyte malondialdehyde levels only in the placebo group (p < 0.001). Lymphocytes from the supplemented group accumulated more vitamin C and vitamin E than placebo after exercise and recovery (p < 0.05). Catalase and glutathione peroxidase activities increased only in the supplemented group after exercise, whereas superoxide dismutase activity increased in both groups (p < 0.05). Heme oxygenase-1 expression was enhanced during the recovery period only in the placebo group (p < 0.01). Bcl-2 expression decreased after exercise only in the placebo group and remained low during the recovery (p < 0.001).

CONCLUSIONS

Intense exercise increases lipid peroxidation, decreases Bcl-2 expression and induces an antioxidant response in lymphocytes. Supplementation with moderate levels of antioxidant vitamins reduces exercise-induced oxidative damage, but without blocking the cellular adaptation to exercise.

Authors+Show Affiliations

Laboratori de Ciències de l'Activitat Física, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18562790

Citation

Sureda, Antoni, et al. "Influence of an Antioxidant Vitamin-enriched Drink On Pre- and Post-exercise Lymphocyte Antioxidant System." Annals of Nutrition & Metabolism, vol. 52, no. 3, 2008, pp. 233-40.
Sureda A, Tauler P, Aguiló A, et al. Influence of an antioxidant vitamin-enriched drink on pre- and post-exercise lymphocyte antioxidant system. Ann Nutr Metab. 2008;52(3):233-40.
Sureda, A., Tauler, P., Aguiló, A., Cases, N., Llompart, I., Tur, J. A., & Pons, A. (2008). Influence of an antioxidant vitamin-enriched drink on pre- and post-exercise lymphocyte antioxidant system. Annals of Nutrition & Metabolism, 52(3), 233-40. https://doi.org/10.1159/000140515
Sureda A, et al. Influence of an Antioxidant Vitamin-enriched Drink On Pre- and Post-exercise Lymphocyte Antioxidant System. Ann Nutr Metab. 2008;52(3):233-40. PubMed PMID: 18562790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of an antioxidant vitamin-enriched drink on pre- and post-exercise lymphocyte antioxidant system. AU - Sureda,Antoni, AU - Tauler,Pedro, AU - Aguiló,Antoni, AU - Cases,Nuria, AU - Llompart,Isabel, AU - Tur,Josep A, AU - Pons,Antoni, Y1 - 2008/06/19/ PY - 2007/09/10/received PY - 2008/01/18/accepted PY - 2008/6/20/pubmed PY - 2008/9/4/medline PY - 2008/6/20/entrez SP - 233 EP - 40 JF - Annals of nutrition & metabolism JO - Ann Nutr Metab VL - 52 IS - 3 N2 - BACKGROUND/AIMS: Our aim was to determine whether the consumption of a functional drink enriched with vitamin C and vitamin E could alleviate exercise-induced oxidative damage in lymphocytes. METHODS: Fourteen male amateur trained runners (32-36 years old) were randomized to receive antioxidant supplementation (152 mg vitamin C/day and 50 mg vitamin E/day) or placebo for 1 month in a double-blind study, and participated in a half-marathon race. The volunteers did not take any other antioxidant supplements. Blood samples were taken before and after the half-marathon and after 3 h recovery. RESULTS: Exercise increased lymphocyte malondialdehyde levels only in the placebo group (p < 0.001). Lymphocytes from the supplemented group accumulated more vitamin C and vitamin E than placebo after exercise and recovery (p < 0.05). Catalase and glutathione peroxidase activities increased only in the supplemented group after exercise, whereas superoxide dismutase activity increased in both groups (p < 0.05). Heme oxygenase-1 expression was enhanced during the recovery period only in the placebo group (p < 0.01). Bcl-2 expression decreased after exercise only in the placebo group and remained low during the recovery (p < 0.001). CONCLUSIONS: Intense exercise increases lipid peroxidation, decreases Bcl-2 expression and induces an antioxidant response in lymphocytes. Supplementation with moderate levels of antioxidant vitamins reduces exercise-induced oxidative damage, but without blocking the cellular adaptation to exercise. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/18562790/Influence_of_an_antioxidant_vitamin_enriched_drink_on_pre__and_post_exercise_lymphocyte_antioxidant_system_ L2 - https://www.karger.com?DOI=10.1159/000140515 DB - PRIME DP - Unbound Medicine ER -