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Effects of simultaneous intakes of fish oil and green tea extracts on plasma, glucose, insulin, C-peptide, and adiponectin and on liver lipid concentrations in mice fed low- and high-fat diets.
Ann Nutr Metab 2008; 52(3):241-9AN

Abstract

AIMS

The purpose of this study was to clarify the effects of a simultaneous intake of fish oil and green tea extracts (GTE) on plasma lipids, glucose (Glu), insulin, C-peptide, and adiponectin concentrations and on liver lipids in mice fed low- and high-fat diets.

METHODS

Male mice (5 months old) were fed low-fat (5%) or high-fat (20%) diets containing 0% (5 or 20% lard), 1% (4 or 19% lard) or 5% (0 or 15% lard) fish oil with or without 1% GTE for 3 months.

RESULTS

Single or combined intakes of fish oil and GTE intakes significantly lowered plasma and liver total cholesterol (T-chol) and triacylglycerol (TG) concentrations in mice on high-fat diets. However, a positive effect of GTE alone was not observed in the plasma T-chol and TG concentrations of mice on low-fat diets. Plasma Glu concentrations were significantly lowered by dietary fish oil in mice on the low- and high-fat diets. A tendency of GTE intake to decrease plasma Glu in mice on both the low- and high-fat diets was not significant. An intake of GTE only minimally influenced plasma insulin, C-peptide, and adiponectin concentrations, but fish oil supplementation increased the adiponectin concentration in mice on the low- and high-fat diets. GTE addition to the diets had no adverse effects on reductions by fish oil.

CONCLUSION

These results suggest that a simultaneous intake of fish oil and GTE can improve plasma and liver lipid and plasma Glu profiles in mice fed a high-fat diet without any negative interactions of fish oil and GTE.

Authors+Show Affiliations

National Food Research Institute, Kannondai, Tsukuba, Japan. nshinya@affrc.go.jpNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18562791

Citation

Shirai, Nobuya, and Hiramitsu Suzuki. "Effects of Simultaneous Intakes of Fish Oil and Green Tea Extracts On Plasma, Glucose, Insulin, C-peptide, and Adiponectin and On Liver Lipid Concentrations in Mice Fed Low- and High-fat Diets." Annals of Nutrition & Metabolism, vol. 52, no. 3, 2008, pp. 241-9.
Shirai N, Suzuki H. Effects of simultaneous intakes of fish oil and green tea extracts on plasma, glucose, insulin, C-peptide, and adiponectin and on liver lipid concentrations in mice fed low- and high-fat diets. Ann Nutr Metab. 2008;52(3):241-9.
Shirai, N., & Suzuki, H. (2008). Effects of simultaneous intakes of fish oil and green tea extracts on plasma, glucose, insulin, C-peptide, and adiponectin and on liver lipid concentrations in mice fed low- and high-fat diets. Annals of Nutrition & Metabolism, 52(3), pp. 241-9. doi:10.1159/000140516.
Shirai N, Suzuki H. Effects of Simultaneous Intakes of Fish Oil and Green Tea Extracts On Plasma, Glucose, Insulin, C-peptide, and Adiponectin and On Liver Lipid Concentrations in Mice Fed Low- and High-fat Diets. Ann Nutr Metab. 2008;52(3):241-9. PubMed PMID: 18562791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of simultaneous intakes of fish oil and green tea extracts on plasma, glucose, insulin, C-peptide, and adiponectin and on liver lipid concentrations in mice fed low- and high-fat diets. AU - Shirai,Nobuya, AU - Suzuki,Hiramitsu, Y1 - 2008/06/19/ PY - 2007/06/25/received PY - 2008/03/10/accepted PY - 2008/6/20/pubmed PY - 2008/9/4/medline PY - 2008/6/20/entrez SP - 241 EP - 9 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 52 IS - 3 N2 - AIMS: The purpose of this study was to clarify the effects of a simultaneous intake of fish oil and green tea extracts (GTE) on plasma lipids, glucose (Glu), insulin, C-peptide, and adiponectin concentrations and on liver lipids in mice fed low- and high-fat diets. METHODS: Male mice (5 months old) were fed low-fat (5%) or high-fat (20%) diets containing 0% (5 or 20% lard), 1% (4 or 19% lard) or 5% (0 or 15% lard) fish oil with or without 1% GTE for 3 months. RESULTS: Single or combined intakes of fish oil and GTE intakes significantly lowered plasma and liver total cholesterol (T-chol) and triacylglycerol (TG) concentrations in mice on high-fat diets. However, a positive effect of GTE alone was not observed in the plasma T-chol and TG concentrations of mice on low-fat diets. Plasma Glu concentrations were significantly lowered by dietary fish oil in mice on the low- and high-fat diets. A tendency of GTE intake to decrease plasma Glu in mice on both the low- and high-fat diets was not significant. An intake of GTE only minimally influenced plasma insulin, C-peptide, and adiponectin concentrations, but fish oil supplementation increased the adiponectin concentration in mice on the low- and high-fat diets. GTE addition to the diets had no adverse effects on reductions by fish oil. CONCLUSION: These results suggest that a simultaneous intake of fish oil and GTE can improve plasma and liver lipid and plasma Glu profiles in mice fed a high-fat diet without any negative interactions of fish oil and GTE. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/18562791/Effects_of_simultaneous_intakes_of_fish_oil_and_green_tea_extracts_on_plasma_glucose_insulin_C_peptide_and_adiponectin_and_on_liver_lipid_concentrations_in_mice_fed_low__and_high_fat_diets_ L2 - https://www.karger.com?DOI=10.1159/000140516 DB - PRIME DP - Unbound Medicine ER -