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Alcohol and tobacco use, and cancer risk for upper aerodigestive tract and liver.
Eur J Cancer Prev. 2008 Aug; 17(4):340-4.EJ

Abstract

This study reviews the association between alcohol, tobacco, and the risk of cancers of the upper digestive and respiratory tract (i.e. oral cavity and pharynx, larynx, and esophagus) and liver. Alcohol drinking and tobacco smoking are the major risk factors for upper aerodigestive tract cancers, accounting for a large proportion (i.e. about three-quarters) of cases in developed countries. Consumption amount is the strongest alcohol-related determinant of risk, whereas the pattern of alcohol-related risk with duration is inconsistent. Both dose and duration of smoking have important effects on the risk of upper aerodigestive tract cancers. The combined exposure to alcohol and tobacco has a multiplicative effect on carcinogenesis of this tract. Alcohol and tobacco consumption are also causally related to liver cancer, although the associations are moderate and a lower fraction of neoplasms is attributable to these factors as compared with cancers of the upper aerodigestive tract. An interaction between alcohol drinking and tobacco smoking has been reported, but the issue is not adequately assessed.

Authors+Show Affiliations

Mario Negri Institute for Pharmacological Research, Milan, Italy. pelucchi@marionegri.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18562959

Citation

Pelucchi, Claudio, et al. "Alcohol and Tobacco Use, and Cancer Risk for Upper Aerodigestive Tract and Liver." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 17, no. 4, 2008, pp. 340-4.
Pelucchi C, Gallus S, Garavello W, et al. Alcohol and tobacco use, and cancer risk for upper aerodigestive tract and liver. Eur J Cancer Prev. 2008;17(4):340-4.
Pelucchi, C., Gallus, S., Garavello, W., Bosetti, C., & La Vecchia, C. (2008). Alcohol and tobacco use, and cancer risk for upper aerodigestive tract and liver. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 17(4), 340-4. https://doi.org/10.1097/CEJ.0b013e3282f75e91
Pelucchi C, et al. Alcohol and Tobacco Use, and Cancer Risk for Upper Aerodigestive Tract and Liver. Eur J Cancer Prev. 2008;17(4):340-4. PubMed PMID: 18562959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol and tobacco use, and cancer risk for upper aerodigestive tract and liver. AU - Pelucchi,Claudio, AU - Gallus,Silvano, AU - Garavello,Werner, AU - Bosetti,Cristina, AU - La Vecchia,Carlo, PY - 2008/6/20/pubmed PY - 2008/8/20/medline PY - 2008/6/20/entrez SP - 340 EP - 4 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 17 IS - 4 N2 - This study reviews the association between alcohol, tobacco, and the risk of cancers of the upper digestive and respiratory tract (i.e. oral cavity and pharynx, larynx, and esophagus) and liver. Alcohol drinking and tobacco smoking are the major risk factors for upper aerodigestive tract cancers, accounting for a large proportion (i.e. about three-quarters) of cases in developed countries. Consumption amount is the strongest alcohol-related determinant of risk, whereas the pattern of alcohol-related risk with duration is inconsistent. Both dose and duration of smoking have important effects on the risk of upper aerodigestive tract cancers. The combined exposure to alcohol and tobacco has a multiplicative effect on carcinogenesis of this tract. Alcohol and tobacco consumption are also causally related to liver cancer, although the associations are moderate and a lower fraction of neoplasms is attributable to these factors as compared with cancers of the upper aerodigestive tract. An interaction between alcohol drinking and tobacco smoking has been reported, but the issue is not adequately assessed. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/18562959/Alcohol_and_tobacco_use_and_cancer_risk_for_upper_aerodigestive_tract_and_liver_ L2 - http://dx.doi.org/10.1097/CEJ.0b013e3282f75e91 DB - PRIME DP - Unbound Medicine ER -