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Adeno-associated virus infection and cervical neoplasia: is there a protective role against human papillomavirus-related carcinogenesis?
Eur J Cancer Prev. 2008 Aug; 17(4):364-8.EJ

Abstract

The aim of this study was to investigate whether adeno-associated virus (AAV) infection can be associated with a reduced risk for human papillomavirus (HPV)-related cervical neoplasia. The study was a prospective descriptive analysis of the prevalence of AAV and HPV DNA sequences in women with and without neoplastic cervical lesions. The study population consisted of 373 women aged 19-65 years old who attended the outpatient colposcopy clinic of a tertiary university center. Cytologic and colposcopic examination, as well as AAV-DNA and HPV-DNA detection and typing were performed in all individuals; biopsies (histological verification) and treatment were performed as appropriate. Women with normal Papanicolaou smear test and normal colposcopic findings served as the control group (n=280). Those with histologically proven cervical pathology were categorized into three groups: (a) women with grade 1 cervical intraepithelial neoplasia (CIN 1) (n=31), (b) women with grades 2 and 3 cervical intraepithelial neoplasia (CIN 2, 3) (n=45), and (c) women with invasive cervical cancer (n=17). AAV infection was confirmed in 63 (16.80%) women. AAV detection was not statistically different between HPV (-) and HPV (+) controls (P=0.06). In the disease groups, however, the prevalence of AAV was statistically significantly lower in the HPV (+) relative to the HPV (-) patients (P=0.0009, P=0.00001, and P=0.0225, for women with low-grade cervical lesions, for women with high-grade cervical lesions, and for women with cervical cancer, respectively). No difference in the prevalence of AAV DNA between HPV-positive and HPV-negative unaffected (control) women is observed. Nevertheless, our results indicate that HPV-infected individuals are less likely to develop cervical neoplasia if AAV is present, and that AAV probably demonstrates a protective role against the pathogenic consequences of HPV infection.

Authors+Show Affiliations

First Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Ring Road, Nea Efkarpia, Thessaloniki 56403, Greece. agorast@auth.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18562963

Citation

Agorastos, Theodoros, et al. "Adeno-associated Virus Infection and Cervical Neoplasia: Is There a Protective Role Against Human Papillomavirus-related Carcinogenesis?" European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 17, no. 4, 2008, pp. 364-8.
Agorastos T, Chrisafi S, Lambropoulos AF, et al. Adeno-associated virus infection and cervical neoplasia: is there a protective role against human papillomavirus-related carcinogenesis? Eur J Cancer Prev. 2008;17(4):364-8.
Agorastos, T., Chrisafi, S., Lambropoulos, A. F., Mikos, T., Constandinides, T. C., Schlehofer, J. R., Schlehofer, B., Kotsis, A., & Bontis, J. N. (2008). Adeno-associated virus infection and cervical neoplasia: is there a protective role against human papillomavirus-related carcinogenesis? European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 17(4), 364-8. https://doi.org/10.1097/CEJ.0b013e3282b6fd2e
Agorastos T, et al. Adeno-associated Virus Infection and Cervical Neoplasia: Is There a Protective Role Against Human Papillomavirus-related Carcinogenesis. Eur J Cancer Prev. 2008;17(4):364-8. PubMed PMID: 18562963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adeno-associated virus infection and cervical neoplasia: is there a protective role against human papillomavirus-related carcinogenesis? AU - Agorastos,Theodoros, AU - Chrisafi,Sofia, AU - Lambropoulos,Alexandros F, AU - Mikos,Themistoklis, AU - Constandinides,Theodoros C, AU - Schlehofer,Joerg R, AU - Schlehofer,Brigitte, AU - Kotsis,Alexander, AU - Bontis,John N, PY - 2008/6/20/pubmed PY - 2008/8/20/medline PY - 2008/6/20/entrez SP - 364 EP - 8 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 17 IS - 4 N2 - The aim of this study was to investigate whether adeno-associated virus (AAV) infection can be associated with a reduced risk for human papillomavirus (HPV)-related cervical neoplasia. The study was a prospective descriptive analysis of the prevalence of AAV and HPV DNA sequences in women with and without neoplastic cervical lesions. The study population consisted of 373 women aged 19-65 years old who attended the outpatient colposcopy clinic of a tertiary university center. Cytologic and colposcopic examination, as well as AAV-DNA and HPV-DNA detection and typing were performed in all individuals; biopsies (histological verification) and treatment were performed as appropriate. Women with normal Papanicolaou smear test and normal colposcopic findings served as the control group (n=280). Those with histologically proven cervical pathology were categorized into three groups: (a) women with grade 1 cervical intraepithelial neoplasia (CIN 1) (n=31), (b) women with grades 2 and 3 cervical intraepithelial neoplasia (CIN 2, 3) (n=45), and (c) women with invasive cervical cancer (n=17). AAV infection was confirmed in 63 (16.80%) women. AAV detection was not statistically different between HPV (-) and HPV (+) controls (P=0.06). In the disease groups, however, the prevalence of AAV was statistically significantly lower in the HPV (+) relative to the HPV (-) patients (P=0.0009, P=0.00001, and P=0.0225, for women with low-grade cervical lesions, for women with high-grade cervical lesions, and for women with cervical cancer, respectively). No difference in the prevalence of AAV DNA between HPV-positive and HPV-negative unaffected (control) women is observed. Nevertheless, our results indicate that HPV-infected individuals are less likely to develop cervical neoplasia if AAV is present, and that AAV probably demonstrates a protective role against the pathogenic consequences of HPV infection. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/18562963/Adeno_associated_virus_infection_and_cervical_neoplasia:_is_there_a_protective_role_against_human_papillomavirus_related_carcinogenesis L2 - http://dx.doi.org/10.1097/CEJ.0b013e3282b6fd2e DB - PRIME DP - Unbound Medicine ER -