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Vaccination with Dukoral against travelers' diarrhea (ETEC) and cholera.
Expert Rev Vaccines. 2008 Jul; 7(5):561-7.ER

Abstract

There is currently only one vaccine available that provides protection against diarrhea caused by Vibrio cholerae and, to a lesser degree, enterotoxigenic Escherichia coli (ETEC). Adverse events of this oral whole-cell/recombinant B-subunit vaccine have been negligible. Protective efficacy against cholera is 85%, while protection against the heat-labile toxin of ETEC reaches 67%. There is still a need for data on protection of Western travelers against travelers' diarrhea in general by Dukoral vaccination. However, current studies show a protective effect of up to 43%. Although the vaccine is only licensed for vaccination against cholera in most Western countries, there is mounting evidence that the oral cholera vaccine is a valuable option to those traveling to high-risk endemic areas. Vaccination against cholera and ETEC should be recommended for at-risk travelers, in particular those with high exposure at their travel destination or high personal risks through fluid loss.

Authors+Show Affiliations

Berlin Center for Travel & Tropical Medicine, Berlin, Germany. jelinek@bctropen.deNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18564011

Citation

Jelinek, Tomas, and Herwig Kollaritsch. "Vaccination With Dukoral Against Travelers' Diarrhea (ETEC) and Cholera." Expert Review of Vaccines, vol. 7, no. 5, 2008, pp. 561-7.
Jelinek T, Kollaritsch H. Vaccination with Dukoral against travelers' diarrhea (ETEC) and cholera. Expert Rev Vaccines. 2008;7(5):561-7.
Jelinek, T., & Kollaritsch, H. (2008). Vaccination with Dukoral against travelers' diarrhea (ETEC) and cholera. Expert Review of Vaccines, 7(5), 561-7. https://doi.org/10.1586/14760584.7.5.561
Jelinek T, Kollaritsch H. Vaccination With Dukoral Against Travelers' Diarrhea (ETEC) and Cholera. Expert Rev Vaccines. 2008;7(5):561-7. PubMed PMID: 18564011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaccination with Dukoral against travelers' diarrhea (ETEC) and cholera. AU - Jelinek,Tomas, AU - Kollaritsch,Herwig, PY - 2008/6/20/pubmed PY - 2008/8/16/medline PY - 2008/6/20/entrez SP - 561 EP - 7 JF - Expert review of vaccines JO - Expert Rev Vaccines VL - 7 IS - 5 N2 - There is currently only one vaccine available that provides protection against diarrhea caused by Vibrio cholerae and, to a lesser degree, enterotoxigenic Escherichia coli (ETEC). Adverse events of this oral whole-cell/recombinant B-subunit vaccine have been negligible. Protective efficacy against cholera is 85%, while protection against the heat-labile toxin of ETEC reaches 67%. There is still a need for data on protection of Western travelers against travelers' diarrhea in general by Dukoral vaccination. However, current studies show a protective effect of up to 43%. Although the vaccine is only licensed for vaccination against cholera in most Western countries, there is mounting evidence that the oral cholera vaccine is a valuable option to those traveling to high-risk endemic areas. Vaccination against cholera and ETEC should be recommended for at-risk travelers, in particular those with high exposure at their travel destination or high personal risks through fluid loss. SN - 1744-8395 UR - https://www.unboundmedicine.com/medline/citation/18564011/Vaccination_with_Dukoral_against_travelers'_diarrhea__ETEC__and_cholera_ L2 - http://www.tandfonline.com/doi/full/10.1586/14760584.7.5.561 DB - PRIME DP - Unbound Medicine ER -