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Antimicrobial susceptibility of Streptococcus pneumoniae isolated from patients with respiratory tract infections in Thailand.

Abstract

A total of 400 clinical Streptococcus pneumoniae strains from patients with respiratory diseases were collected from January 2002 to December 2005. In this study, an increased prevalence of penicillin-nonsusceptible S. pneumoniae (PNSP) from 63% in 2002-2003 to 69% in 2004-2005 was found. During 2004-2005, 56% were erythromycin-nonsusceptible S. pneumoniae (ENSP) and 54% were both PNSP and ENSP. The PNSP, ENSP and PNSP+ENSP groups showed similar trends, ie, sensitive to amoxicillin/clavulanate (range 97.2-98.5%), levofloxacin (range 90.7-92.4%), ceftriaxone (range 87.1-89.4%), and ofloxacin (range 64.8-66.1%). Lower levels of susceptibility were detected for azithromycin, clarithromycin, cefdinir, cefprozil, clindamycin, co-trimoxazole, chloramphenicol and tetracycline in penicillin and erythromycin-nonsusceptible strains. Of the macrolide-resistant S. pneumoniae, 55% of strains exhibited the M phenotype and 45% the constitutive MLS(B) phenotype. No pneumococci with the inducible MLS(B) phenotype were detected in Thailand.

Authors+Show Affiliations

Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18564685

Citation

Srifuengfung, Somporn, et al. "Antimicrobial Susceptibility of Streptococcus Pneumoniae Isolated From Patients With Respiratory Tract Infections in Thailand." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 39, no. 3, 2008, pp. 461-6.
Srifuengfung S, Tribuddharat C, Champreeda P, et al. Antimicrobial susceptibility of Streptococcus pneumoniae isolated from patients with respiratory tract infections in Thailand. Southeast Asian J Trop Med Public Health. 2008;39(3):461-6.
Srifuengfung, S., Tribuddharat, C., Champreeda, P., Daniels, J., Chokephaibulkit, K., Wongwan, N., & Polwichai, P. (2008). Antimicrobial susceptibility of Streptococcus pneumoniae isolated from patients with respiratory tract infections in Thailand. The Southeast Asian Journal of Tropical Medicine and Public Health, 39(3), 461-6.
Srifuengfung S, et al. Antimicrobial Susceptibility of Streptococcus Pneumoniae Isolated From Patients With Respiratory Tract Infections in Thailand. Southeast Asian J Trop Med Public Health. 2008;39(3):461-6. PubMed PMID: 18564685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial susceptibility of Streptococcus pneumoniae isolated from patients with respiratory tract infections in Thailand. AU - Srifuengfung,Somporn, AU - Tribuddharat,Chanwit, AU - Champreeda,Preecha, AU - Daniels,Justin, AU - Chokephaibulkit,Kulkanya, AU - Wongwan,Nithita, AU - Polwichai,Pitimon, PY - 2008/6/21/pubmed PY - 2008/10/22/medline PY - 2008/6/21/entrez SP - 461 EP - 6 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 39 IS - 3 N2 - A total of 400 clinical Streptococcus pneumoniae strains from patients with respiratory diseases were collected from January 2002 to December 2005. In this study, an increased prevalence of penicillin-nonsusceptible S. pneumoniae (PNSP) from 63% in 2002-2003 to 69% in 2004-2005 was found. During 2004-2005, 56% were erythromycin-nonsusceptible S. pneumoniae (ENSP) and 54% were both PNSP and ENSP. The PNSP, ENSP and PNSP+ENSP groups showed similar trends, ie, sensitive to amoxicillin/clavulanate (range 97.2-98.5%), levofloxacin (range 90.7-92.4%), ceftriaxone (range 87.1-89.4%), and ofloxacin (range 64.8-66.1%). Lower levels of susceptibility were detected for azithromycin, clarithromycin, cefdinir, cefprozil, clindamycin, co-trimoxazole, chloramphenicol and tetracycline in penicillin and erythromycin-nonsusceptible strains. Of the macrolide-resistant S. pneumoniae, 55% of strains exhibited the M phenotype and 45% the constitutive MLS(B) phenotype. No pneumococci with the inducible MLS(B) phenotype were detected in Thailand. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/18564685/Antimicrobial_susceptibility_of_Streptococcus_pneumoniae_isolated_from_patients_with_respiratory_tract_infections_in_Thailand_ DB - PRIME DP - Unbound Medicine ER -